INT96304

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Context Info
Confidence 0.66
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 0.63
Pain Relevance 3.12

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transmembrane transporter activity (Slc22a8) plasma membrane (Slc22a8)
Anatomy Link Frequency
melanocyte 2
astrocytes 1
proximal convoluted tubules 1
kidney 1
Slc22a8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 8 100.00 Very High Very High Very High
narcan 6 99.52 Very High Very High Very High
methotrexate 29 99.00 Very High Very High Very High
qutenza 4 97.68 Very High Very High Very High
Calcitonin gene-related peptide 10 95.44 Very High Very High Very High
c fibre 2 93.64 High High
Clonidine 2 88.36 High High
Kinase C 2 86.96 High High
Desipramine 1 85.40 High High
cINOD 5 80.64 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 3 80.40 Quite High
Uremia 3 75.00 Quite High
Chronic Renal Failure 2 65.44 Quite High
Overdose 2 64.88 Quite High
Nociception 2 35.32 Quite Low
Poisoning 3 25.32 Quite Low
Toxicity 9 5.00 Very Low Very Low Very Low
Body Weight 3 5.00 Very Low Very Low Very Low
Alopecia 1 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purpose of this study was to evaluate the effect of celecoxib on methotrexate tubular secretion using a renal cell line stably expressing human OAT3 (S2-hOAT3), and to evaluate the pharmacokinetic interaction of the two drugs in rats. [3H]methotrexate uptake into S2-hOAT3 cells was significantly inhibited by celecoxib in a concentration-dependent manner and the Ki value was 35.3 microM.
Gene_expression (expressing) of OAT3 associated with methotrexate
1) Confidence 0.66 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20478302 Disease Relevance 0.08 Pain Relevance 0.49
Northern analysis and RT-PCR show that these cells do not express the organic cation transporters OCT2 and OCT3.
Neg (not) Gene_expression (express) of OCT3
2) Confidence 0.62 Published 2001 Journal Biochim. Biophys. Acta Section Abstract Doc Link 11406107 Disease Relevance 0 Pain Relevance 0.09
The purpose of this study was to evaluate the effect of celecoxib on methotrexate tubular secretion using a renal cell line stably expressing human OAT3 (S2-hOAT3), and to evaluate the pharmacokinetic interaction of the two drugs in rats. [3H]methotrexate uptake into S2-hOAT3 cells was significantly inhibited by celecoxib in a concentration-dependent manner and the Ki value was 35.3 microM.
Gene_expression (expressing) of hOAT3 associated with methotrexate
3) Confidence 0.51 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20478302 Disease Relevance 0.08 Pain Relevance 0.49
RT-PCR demonstrated that astrocytes expressed low levels of OCT1, OCT2 and OCT3 mRNA, but the functional characteristics of choline uptake are very different from the known properties of these OCTs.
Gene_expression (expressed) of OCT3 in astrocytes
4) Confidence 0.48 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16000150 Disease Relevance 0 Pain Relevance 0.12
Oat3 in the kidney of developing rats is expressed as early as postnatal day 10 (Buist et al. 2002); however, Oat3 does not seem to participate in the transport of the MeHg–NAC complex (Koh et al. 2002).
Gene_expression (expressed) of Oat3 in kidney
5) Confidence 0.41 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2199271 Disease Relevance 0.12 Pain Relevance 0.12
Protein expression of rOat1 and rOat3, assessed by Western blot analysis, was decreased in 5/6 Nx rats.
Gene_expression (expression) of rOat3
6) Confidence 0.23 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15879000 Disease Relevance 0.27 Pain Relevance 0
Two other established MrgC agonists (gamma2-melanocyte stimulating hormone and BAM8-22) were ineffective.
Gene_expression (established) of BAM8-22 in melanocyte associated with agonist
7) Confidence 0.00 Published 2008 Journal Neuroscience Section Abstract Doc Link 18065157 Disease Relevance 0 Pain Relevance 0.85
Two other established MrgC agonists (gamma2-melanocyte stimulating hormone and BAM8-22) were ineffective.
Gene_expression (ineffective) of BAM8-22 in melanocyte associated with agonist
8) Confidence 0.00 Published 2008 Journal Neuroscience Section Abstract Doc Link 18065157 Disease Relevance 0 Pain Relevance 0.83
By RT-PCR, rOat8 mRNA was expressed in proximal convoluted tubules and cortical and outer medullary collecting ducts, whereas in immunochemical studies, Oat8 was identified as the ñ58 kDa protein that in the collecting duct colocalized with the V-ATPase in plasma membranes and intracellular vesicles in various subtypes of intercalated cells.
Gene_expression (expressed) of rOat8 in proximal convoluted tubules
9) Confidence 0.00 Published 2008 Journal Cell. Physiol. Biochem. Section Abstract Doc Link 18441515 Disease Relevance 0.08 Pain Relevance 0.12

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