INT96319

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Context Info
Confidence 0.56
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 18
Disease Relevance 12.82
Pain Relevance 9.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (gr)
Anatomy Link Frequency
cortex 5
anatomic regions 2
frontal cortex 2
dorsal 1
locus coeruleus 1
gr (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 13 100.00 Very High Very High Very High
fluoxetine 34 99.98 Very High Very High Very High
corticosteroid 15 99.08 Very High Very High Very High
amygdala 12 98.92 Very High Very High Very High
intrathecal 3 98.72 Very High Very High Very High
Locus ceruleus 8 98.52 Very High Very High Very High
depression 24 97.80 Very High Very High Very High
Inflammation 205 97.68 Very High Very High Very High
antidepressant 14 97.60 Very High Very High Very High
Hippocampus 10 97.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Chronic Obstructive Pulmonary Disease 324 100.00 Very High Very High Very High
Urological Neuroanatomy 8 99.28 Very High Very High Very High
Stress 112 99.24 Very High Very High Very High
Sprains And Strains 21 99.10 Very High Very High Very High
Depression 36 97.80 Very High Very High Very High
INFLAMMATION 291 97.68 Very High Very High Very High
Disease 108 91.52 High High
Attention Deficit Hyperactivity Disorder 1 76.48 Quite High
Anxiety Disorder 5 74.80 Quite High
Pulmonary Disease 7 72.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, neither the time of onset nor the mechanism(s) leading to decreased GR expression during postnatal development are known.
Negative_regulation (decreased) of Gene_expression (expression) of GR
1) Confidence 0.56 Published 2010 Journal Dev. Neurosci. Section Abstract Doc Link 20453467 Disease Relevance 0.76 Pain Relevance 0.05
In both strains, real-time RT-PCR experiments revealed that decreased expression of GR in adolescence and adulthood is, in fact, preceded by increased GR expression during early life stress exposure.
Negative_regulation (decreased) of Gene_expression (expression) of GR associated with stress and sprains and strains
2) Confidence 0.56 Published 2010 Journal Dev. Neurosci. Section Abstract Doc Link 20453467 Disease Relevance 1.18 Pain Relevance 0.15
Moreover, there was no consistent overlap of anatomic regions affected by decreased GR and egr-1 protein expression.
Negative_regulation (decreased) of Gene_expression (expression) of GR in anatomic regions
3) Confidence 0.41 Published 2010 Journal Dev. Neurosci. Section Abstract Doc Link 20453467 Disease Relevance 0.98 Pain Relevance 0.19
In both strains, real-time RT-PCR experiments revealed that decreased expression of GR in adolescence and adulthood is, in fact, preceded by increased GR expression during early life stress exposure.
Negative_regulation (preceded) of Gene_expression (expression) of GR associated with stress and sprains and strains
4) Confidence 0.41 Published 2010 Journal Dev. Neurosci. Section Abstract Doc Link 20453467 Disease Relevance 1.20 Pain Relevance 0.16
In both strains, real-time RT-PCR experiments revealed that decreased expression of GR in adolescence and adulthood is, in fact, preceded by increased GR expression during early life stress exposure.
Negative_regulation (decreased) of Gene_expression (expression) of GR associated with stress and sprains and strains
5) Confidence 0.41 Published 2010 Journal Dev. Neurosci. Section Abstract Doc Link 20453467 Disease Relevance 1.18 Pain Relevance 0.15
Fluoxetine decreased glucocorticoid receptor (GR) gene expression in the prefrontal cortex, amygdala, locus coeruleus and dorsal raphé nucleus, and increased locus coeruleus tyrosine hydroxylase and dorsal raphé nucleus tryptophan hydroxylase-2 (TPH2) gene expression.
Negative_regulation (decreased) of Gene_expression (expression) of GR in cortex associated with locus ceruleus, amygdala and fluoxetine
6) Confidence 0.36 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20374287 Disease Relevance 0.50 Pain Relevance 1.10
The capacity of GR to repress NF-?
Negative_regulation (repress) of Gene_expression (capacity) of GR
7) Confidence 0.21 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.16 Pain Relevance 0.23
Fluoxetine decreased glucocorticoid receptor (GR) gene expression in the prefrontal cortex, amygdala, locus coeruleus and dorsal raphé nucleus, and increased locus coeruleus tyrosine hydroxylase and dorsal raphé nucleus tryptophan hydroxylase-2 (TPH2) gene expression.
Negative_regulation (decreased) of in locus coeruleus Gene_expression (expression) of GR in cortex associated with locus ceruleus, amygdala and fluoxetine
8) Confidence 0.12 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20374287 Disease Relevance 0.50 Pain Relevance 1.10
Fluoxetine decreased glucocorticoid receptor (GR) gene expression in the prefrontal cortex, amygdala, locus coeruleus and dorsal raphé nucleus, and increased locus coeruleus tyrosine hydroxylase and dorsal raphé nucleus tryptophan hydroxylase-2 (TPH2) gene expression.
Negative_regulation (decreased) of in amygdala Gene_expression (expression) of GR in cortex associated with locus ceruleus, amygdala and fluoxetine
9) Confidence 0.12 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20374287 Disease Relevance 0.50 Pain Relevance 1.10
Fluoxetine decreased glucocorticoid receptor (GR) gene expression in the prefrontal cortex, amygdala, locus coeruleus and dorsal raphé nucleus, and increased locus coeruleus tyrosine hydroxylase and dorsal raphé nucleus tryptophan hydroxylase-2 (TPH2) gene expression.
Negative_regulation (decreased) of in dorsal Gene_expression (expression) of GR in cortex associated with locus ceruleus, amygdala and fluoxetine
10) Confidence 0.12 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20374287 Disease Relevance 0.50 Pain Relevance 1.10
A failure to respond to corticosteroids may therefore result from lack of binding to GR, reduced GR expression, lack of co-repressor activity or enhanced activation of inflammatory pathways.
Negative_regulation (reduced) of Gene_expression (expression) of GR associated with corticosteroid and inflammation
11) Confidence 0.08 Published 2009 Journal Biochem. Soc. Trans. Section Abstract Doc Link 19614602 Disease Relevance 0.77 Pain Relevance 0.48
These data indicate that the increase in hippocampal GR level and low concentration of FKBP51 in the frontal cortex may be responsible for enhanced glucocorticoid action in depression.
Negative_regulation (concentration) of Gene_expression (level) of GR in frontal cortex associated with depression and urological neuroanatomy
12) Confidence 0.06 Published 2009 Journal Psychoneuroendocrinology Section Abstract Doc Link 19195790 Disease Relevance 0.86 Pain Relevance 0.33
A failure to respond to corticosteroids may therefore result from lack of binding to GR, reduced GR expression, lack of co-repressor activity or enhanced activation of inflammatory pathways.
Negative_regulation (reduced) of Gene_expression (expression) of GR associated with corticosteroid and inflammation
13) Confidence 0.05 Published 2009 Journal Biochem. Soc. Trans. Section Abstract Doc Link 19614602 Disease Relevance 0.77 Pain Relevance 0.48
is reduced, there is no apparent change in the expression of GR?.
Negative_regulation (reduced) of Gene_expression (expression) of GR
14) Confidence 0.05 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 1.03 Pain Relevance 0.21
expression have been assessed in COPD, but although the expression of GR?
Negative_regulation (assessed) of Gene_expression (expression) of GR associated with chronic obstructive pulmonary disease
15) Confidence 0.05 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 0.98 Pain Relevance 0.19
isoform.53 However, other studies have found low expression of GR?
Negative_regulation (low) of Gene_expression (expression) of GR
16) Confidence 0.05 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 0.94 Pain Relevance 0.24
In situ hybridization histochemistry showed that the antidepressants decreased MR mRNA expression in all hippocampal subregions (e.g. 45% decrease in CA1 with venlafaxine, P<0.001), while GR mRNA expression was selectively reduced in the CA3 subregion.
Negative_regulation (reduced) of Gene_expression (expression) of GR associated with antidepressant
17) Confidence 0.03 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11406320 Disease Relevance 0 Pain Relevance 0.61
Intrathecal coadministration of morphine with an adenylyl cyclase inhibitor (2',5'-dideoxyadenosine) or a protein kinase A inhibitor (H89) also significantly attenuated morphine-induced NR1 and PKCgamma expression, whereas intrathecal treatment with an adenylyl cyclase activator (forskolin) alone mimicked morphine-induced expression of GR, NR1, and PKCgamma.
Negative_regulation (mimicked) of Gene_expression (expression) of GR associated with morphine and intrathecal
18) Confidence 0.03 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16319314 Disease Relevance 0 Pain Relevance 1.52

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