INT96320

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.38
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (gr)
gr (Mus musculus)
Pain Link Frequency Relevance Heat
Desipramine 1 99.36 Very High Very High Very High
fluoxetine 6 99.34 Very High Very High Very High
antidepressant 9 99.02 Very High Very High Very High
Hippocampus 3 76.40 Quite High
corticosteroid 3 75.76 Quite High
tricyclic antidepressant 1 33.60 Quite Low
depression 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Stress 12 100.00 Very High Very High Very High
Sprains And Strains 4 98.32 Very High Very High Very High
Cancer 1 96.08 Very High Very High Very High
Urological Neuroanatomy 1 58.96 Quite High
Depression 1 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, chronic treatment with the antidepressant drug fluoxetine during adolescence or adulthood reversed the effect of early life stress on adult GR mRNA expression.
Negative_regulation (reversed) of Transcription (expression) of GR associated with stress, antidepressant and fluoxetine
1) Confidence 0.41 Published 2010 Journal Dev. Neurosci. Section Abstract Doc Link 20453467 Disease Relevance 1.28 Pain Relevance 0.18
We found that the transcriptional activity of GR stimulated by 50 nM corticosterone was strongly attenuated by imipramine, desipramine, fluoxetine and tianeptine in a concentration-dependent way, whereas reboxetine had only a weak effect and venlafaxine was inactive.
Negative_regulation (attenuated) of Transcription (activity) of GR associated with desipramine and fluoxetine
2) Confidence 0.37 Published 2008 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 18441395 Disease Relevance 0.10 Pain Relevance 0.26
In situ hybridization histochemistry showed that the antidepressants decreased MR mRNA expression in all hippocampal subregions (e.g. 45% decrease in CA1 with venlafaxine, P<0.001), while GR mRNA expression was selectively reduced in the CA3 subregion.
Negative_regulation (reduced) of Transcription (expression) of GR associated with antidepressant
3) Confidence 0.03 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11406320 Disease Relevance 0 Pain Relevance 0.61

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox