INT96324

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Context Info
Confidence 0.56
First Reported 2001
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.01
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Nr3c2) nucleus (Nr3c2) cytoplasm (Nr3c2)
Anatomy Link Frequency
dentate gyrus 2
Nr3c2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 6 99.98 Very High Very High Very High
corticosteroid 22 93.88 High High
fluoxetine 8 92.00 High High
antagonist 2 87.04 High High
Endep 1 83.24 Quite High
Hippocampus 62 82.32 Quite High
Neuronal excitability 2 54.80 Quite High
Pyramidal cell 2 36.44 Quite Low
depression 4 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Post-traumatic Stress Disorder 54 99.84 Very High Very High Very High
Aging 1 99.76 Very High Very High Very High
Stress 108 97.16 Very High Very High Very High
Syndrome 4 95.60 Very High Very High Very High
Cognitive Disorder 2 67.92 Quite High
Disease 4 63.80 Quite High
Neurodegenerative Disease 4 34.04 Quite Low
Death 6 33.04 Quite Low
Apoptosis 4 32.60 Quite Low
Anxiety Disorder 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is not known whether homodimers, heterodimers, or both caused the decreased expression of MR and GR.
Spec (whether) Negative_regulation (decreased) of Gene_expression (expression) of MR
1) Confidence 0.56 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.49 Pain Relevance 0.11
Interestingly, previous studies also suggest different regulation patterns in MR and GR expression with decreased MR/GR ratio in PTSD.
Negative_regulation (decreased) of Gene_expression (ratio) of MR/GR associated with post-traumatic stress disorder
2) Confidence 0.41 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.42 Pain Relevance 0.10
MR mRNA expression was reduced with ageing in all hippocampal subfields except CA4 (35% decrease in dentate gyrus (DG) and CA2, P<0.05) and GR mRNA was decreased selectively in CA1 (17% decrease, P<0.05).
Negative_regulation (reduced) of Gene_expression (expression) of MR mRNA in dentate gyrus associated with aging
3) Confidence 0.14 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12393271 Disease Relevance 0.10 Pain Relevance 0.63
In situ hybridization histochemistry showed that the antidepressants decreased MR mRNA expression in all hippocampal subregions (e.g. 45% decrease in CA1 with venlafaxine, P<0.001), while GR mRNA expression was selectively reduced in the CA3 subregion.
Negative_regulation (decreased) of Gene_expression (expression) of MR mRNA associated with antidepressant
4) Confidence 0.08 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11406320 Disease Relevance 0 Pain Relevance 0.60

General Comments

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