INT96326

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Context Info
Confidence 0.27
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.50
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Serpina6) extracellular space (Serpina6) extracellular region (Serpina6)
molecular_function (Serpina6) cellular_component (Serpina6) biological_process (Serpina6)
Anatomy Link Frequency
pituitary 2
Serpina6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
corticosteroid 4 100.00 Very High Very High Very High
Hippocampus 2 99.68 Very High Very High Very High
antidepressant 4 99.46 Very High Very High Very High
fluoxetine 3 80.64 Quite High
withdrawal 6 5.00 Very Low Very Low Very Low
transdermal 6 5.00 Very Low Very Low Very Low
Dismenorea 4 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 6 92.44 High High
Insulin Resistance 1 41.52 Quite Low
Diabetes Mellitus 5 20.76 Low Low
Metabolic Syndrome 1 9.80 Low Low
Reprotox - General 1 23 5.00 Very Low Very Low Very Low
Hemorrhage 19 5.00 Very Low Very Low Very Low
Vomiting 12 5.00 Very Low Very Low Very Low
Reprotox - General 2 8 5.00 Very Low Very Low Very Low
Body Weight 6 5.00 Very Low Very Low Very Low
Headache 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic treatment with antidepressant drugs (2 weeks or longer) increases corticosteroid receptor mRNA expression in the hippocampus and reduces hypothalamic-pituitary-adrenal axis activity in parallel with improving mood and neuroendocrine function.
Positive_regulation (increases) of Gene_expression (expression) of corticosteroid receptor in pituitary associated with corticosteroid, antidepressant and hippocampus
1) Confidence 0.27 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11406320 Disease Relevance 0 Pain Relevance 0.41
Sex-hormone-binding globulin increased markedly more with NuvaRing, whereas corticosteroid-binding globulin levels increased to a lesser degree.
Positive_regulation (increased) of Gene_expression (levels) of corticosteroid-binding globulin associated with corticosteroid
2) Confidence 0.03 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2990910 Disease Relevance 0.50 Pain Relevance 0.05

General Comments

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