INT96330

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Context Info
Confidence 0.14
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.83
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1) enzyme binding (Grin1) cytoplasm (Grin1)
Anatomy Link Frequency
pyramidal neurons 2
Grin1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 11 100.00 Very High Very High Very High
Kinase C 5 100.00 Very High Very High Very High
Gabapentin 2 99.98 Very High Very High Very High
Pyramidal cell 20 98.96 Very High Very High Very High
Analgesic 1 97.84 Very High Very High Very High
Pain 1 96.76 Very High Very High Very High
diabetic neuropathy 1 94.92 High High
Dorsal horn neuron 1 86.56 High High
Inflammation 2 83.96 Quite High
Freund adjuvant 3 81.96 Quite High
Disease Link Frequency Relevance Heat
Pain 1 96.76 Very High Very High Very High
Nervous System Injury 1 95.56 Very High Very High Very High
Diabetic Neuropathy 1 94.92 High High
Cancer 1 93.96 High High
INFLAMMATION 2 83.96 Quite High
Depression 1 80.88 Quite High
Schizophrenia 3 80.28 Quite High
Mental Disorders 2 79.28 Quite High
Injury 1 61.52 Quite High
Cognitive Disorder 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gabapentin actions on N-methyl-D-aspartate receptor channels are protein kinase C-dependent.
Regulation (dependent) of Regulation (actions) of N-methyl-D-aspartate receptor associated with kinase c, nmda receptor and gabapentin
1) Confidence 0.14 Published 2001 Journal Pain Section Title Doc Link 11406342 Disease Relevance 0.59 Pain Relevance 0.99
The counteractive effect of 5-HT2A/C on 5-HT1A regulation of synaptic NMDAR response was also observed in PFC pyramidal neurons from intact animals treated with various 5-HT-related drugs.
Regulation (regulation) of Regulation (response) of NMDAR in pyramidal neurons associated with pyramidal cell
2) Confidence 0.07 Published 2008 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2427346 Disease Relevance 0.24 Pain Relevance 0.21

General Comments

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