INT96351

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Context Info
Confidence 0.50
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 4
Disease Relevance 6.09
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (DAB2) plasma membrane (DAB2) nucleus (DAB2)
cytoplasm (DAB2)
Anatomy Link Frequency
lymph node 2
DAB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 4 94.72 High High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 24 100.00 Very High Very High Very High
Metastasis 12 100.00 Very High Very High Very High
Adenocarcinoma 8 100.00 Very High Very High Very High
Cancer 36 98.52 Very High Very High Very High
Ovarian Cancer 4 96.80 Very High Very High Very High
Reprotox - General 1 4 96.04 Very High Very High Very High
Pancreatitis 4 94.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, levels of expression of DOC-2 in lymph node metastases were markedly decreased in comparison with levels in primary tumors.
Negative_regulation (decreased) of Gene_expression (expression) of DOC-2 in lymph node associated with cancer and metastasis
1) Confidence 0.50 Published 2001 Journal Lab. Invest. Section Abstract Doc Link 11406647 Disease Relevance 1.73 Pain Relevance 0.09
Doc-2/hDab2 expression is up-regulated in primary pancreatic cancer but reduced in metastasis.
Negative_regulation (reduced) of Gene_expression (expression) of hDab2 associated with pancreatic cancer and metastasis
2) Confidence 0.50 Published 2001 Journal Lab. Invest. Section Title Doc Link 11406647 Disease Relevance 1.43 Pain Relevance 0.06
In conclusion, DOC-2 is overexpressed in primary pancreatic adenocarcinoma but down-regulated in metastatic disease, suggesting a tumor suppressor function of DOC-2 in the late steps of pancreatic carcinogenesis.
Negative_regulation (down-regulated) of Gene_expression (overexpressed) of DOC-2 associated with adenocarcinoma, cancer and metastasis
3) Confidence 0.37 Published 2001 Journal Lab. Invest. Section Abstract Doc Link 11406647 Disease Relevance 1.51 Pain Relevance 0.08
Doc-2/hDab2 expression is up-regulated in primary pancreatic cancer but reduced in metastasis.
Negative_regulation (reduced) of Gene_expression (expression) of Doc-2 associated with pancreatic cancer and metastasis
4) Confidence 0.36 Published 2001 Journal Lab. Invest. Section Title Doc Link 11406647 Disease Relevance 1.43 Pain Relevance 0.06

General Comments

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