INT96364

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Context Info
Confidence 0.36
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.86
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (Ugcg) Golgi apparatus (Ugcg)
Anatomy Link Frequency
joints 1
liver 1
hepatocytes 1
Ugcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 4 99.08 Very High Very High Very High
Paracetamol 87 98.64 Very High Very High Very High
peptic ulcer disease 1 96.68 Very High Very High Very High
antagonist 2 90.92 High High
Dopamine 1 86.76 High High
rheumatoid arthritis 25 86.56 High High
conotoxin 1 84.64 Quite High
dexamethasone 130 79.16 Quite High
Inflammation 28 77.04 Quite High
Arthritis 49 45.72 Quite Low
Disease Link Frequency Relevance Heat
Arthritis 62 99.84 Very High Very High Very High
Targeted Disruption 1 99.78 Very High Very High Very High
Injury 11 97.88 Very High Very High Very High
Disease 5 96.68 Very High Very High Very High
Ulcers 1 96.36 Very High Very High Very High
Hepatotoxicity 13 96.00 Very High Very High Very High
Infection 1 95.80 Very High Very High Very High
Frailty 1 93.28 High High
Muscle Weakness 1 92.80 High High
Osteoporosis 8 92.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The guanylate cyclase inhibitor 1H-[1,2,4]oxidiazolo[4,3-a]quinoxalin-1-one (ODQ) also enhanced GCs to the same extent as TTX and L-NNA, and each of the three agents prevented the effects of the others.
Positive_regulation (enhanced) of GCs associated with tetrodotoxin
1) Confidence 0.36 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11408281 Disease Relevance 0 Pain Relevance 0.52
Conversely, transgenic mice with enhanced GCS activity were found resistant to APAP-induced liver injury [57].
Positive_regulation (enhanced) of GCS in liver associated with targeted disruption, paracetamol and injury
2) Confidence 0.21 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994383 Disease Relevance 0.50 Pain Relevance 0.55
Therefore, a delivery system that could selectively direct GCs to arthritic joints but spare the skeletal and soft tissues would have a significant therapeutic advantage.
Positive_regulation (direct) of GCs in joints associated with arthritis
3) Confidence 0.14 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 1.06 Pain Relevance 0.46
Furthermore, the activity of y-glutamylcysteine synthetase (gamma-GCS), the rate-limiting enzyme in GSH biosynthesis, was also increased by DCE-GS triester treatment (1.4-fold in 24 h with 1.0 mm).
Positive_regulation (increased) of gamma-GCS
4) Confidence 0.12 Published 2001 Journal Biol. Pharm. Bull. Section Abstract Doc Link 11456112 Disease Relevance 0.16 Pain Relevance 0.16
These results suggested that DCE-GS triester, which is transported into hepatocytes much more effectively than DCE-GS and other DCE-GS esters due to its greater lipophilicity, was hydrolyzed to DCE-GS, and then the DCE-GS produced increased the GSH level via activation of gamma-GCS in rat hepatocytes.
Positive_regulation (activation) of gamma-GCS in hepatocytes
5) Confidence 0.12 Published 2001 Journal Biol. Pharm. Bull. Section Abstract Doc Link 11456112 Disease Relevance 0.14 Pain Relevance 0.14

General Comments

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