INT96365

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Context Info
Confidence 0.27
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 1.47
Pain Relevance 3.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (Ugcg) Golgi apparatus (Ugcg)
Anatomy Link Frequency
plasma 1
liver 1
smooth muscle 1
Ugcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 332 99.98 Very High Very High Very High
antagonist 6 99.36 Very High Very High Very High
Dopamine 3 98.36 Very High Very High Very High
tetrodotoxin 12 96.88 Very High Very High Very High
conotoxin 3 96.24 Very High Very High Very High
Potency 6 77.52 Quite High
cytokine 23 54.16 Quite High
Inflammation 13 5.00 Very Low Very Low Very Low
Spinal cord 12 5.00 Very Low Very Low Very Low
Multiple sclerosis 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 44 98.92 Very High Very High Very High
Hepatotoxicity 36 97.64 Very High Very High Very High
Overdose 24 92.08 High High
Stress 36 88.52 High High
Targeted Disruption 4 87.84 High High
Asthma 2 16.16 Low Low
Multiple Sclerosis 17 5.00 Very Low Very Low Very Low
INFLAMMATION 13 5.00 Very Low Very Low Very Low
Autoimmune Disease 13 5.00 Very Low Very Low Very Low
Necrosis 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GCs were abolished by electrical field stimulation, S-nitroso-N-acetyl-penicillamine, and 8-bromo-cGMP.
Negative_regulation (abolished) of GCs
1) Confidence 0.27 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11408281 Disease Relevance 0 Pain Relevance 0.50
Constitutive release of nitric oxide from enteric neurons sustains cGMP synthesis in the colonic smooth muscle to suppress spontaneous in vitro GCs.
Negative_regulation (suppress) of GCs in smooth muscle
2) Confidence 0.27 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11408281 Disease Relevance 0 Pain Relevance 0.38
The GCs were unaffected by hexamethonium, atropine, and antagonists of serotonergic (5-HT(1--4)), histaminergic (H(1--2)), and tachykininergic (NK(1--2)) receptors but enhanced by NK(3) receptor antagonism.
Neg (unaffected) Negative_regulation (unaffected) of GCs associated with antagonist
3) Confidence 0.27 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11408281 Disease Relevance 0 Pain Relevance 0.51
However, NAC is only protective as long as a viable cysteine-driven synthesis of GSH is operative [25] since it is ineffective when the hepatic store of GSH is artificially depleted by a treatment with buthionine sulfoximine, an inhibitor of GCS [18,39].
Negative_regulation (inhibitor) of GCS
4) Confidence 0.21 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994383 Disease Relevance 0.51 Pain Relevance 0.23
Protection by NAC, HYTAU and TAU against APAP-induced liver injury is also a reflection of their ability to prevent the loss of GCS activity to a toxic dose of APAP, an enzyme that plays a crucial role in protecting the liver against hepatotoxic compounds by regulating the de novo synthesis of GSH.
Negative_regulation (loss) of GCS in liver associated with paracetamol and injury
5) Confidence 0.18 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994383 Disease Relevance 0.46 Pain Relevance 0.40
The results summarized in Figure 5, 6, 7 indicate that a toxic dose of APAP lowered the plasma activities of GR, GST and GCS, respectively, and that all the test compounds offered different degrees of protection against such losses.
Negative_regulation (lowered) of GCS in plasma associated with paracetamol
6) Confidence 0.16 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994383 Disease Relevance 0 Pain Relevance 0.76
-GCS knockdown rats [56] or a specific inhibitor of GCS activity such as buthionine sulfoximine [18] and in which hepatotoxicity by APAP was more extensive than in normal or uninhibited animals.
Negative_regulation (inhibitor) of GCS associated with paracetamol and hepatotoxicity
7) Confidence 0.16 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994383 Disease Relevance 0.50 Pain Relevance 0.49
Although there are previous reports about the inhibitory effect of GCs on IFN-?
Negative_regulation (effect) of GCs
8) Confidence 0.10 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0 Pain Relevance 0.09

General Comments

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