INT96365

Context Info Confidence 0.27 First Reported 2001 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 5 Total Number 8 Disease Relevance 1.47 Pain Relevance 3.37

transferase activity, transferring glycosyl groups (Ugcg) Golgi apparatus (Ugcg)

Anatomy Link Frequency plasma 1 liver 1 smooth muscle 1 Ugcg (Rattus norvegicus)

Pain Link Frequency Relevance Heat Paracetamol 332 99.98 antagonist 6 99.36 Dopamine 3 98.36 tetrodotoxin 12 96.88 conotoxin 3 96.24 Potency 6 77.52 cytokine 23 54.16 Inflammation 13 5.00 Spinal cord 12 5.00 Multiple sclerosis 11 5.00

Disease Link Frequency Relevance Heat Injury 44 98.92 Hepatotoxicity 36 97.64 Overdose 24 92.08 Stress 36 88.52 Targeted Disruption 4 87.84 Asthma 2 16.16 Multiple Sclerosis 17 5.00 INFLAMMATION 13 5.00 Autoimmune Disease 13 5.00 Necrosis 9 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

GCs were abolished by electrical field stimulation, S-nitroso-N-acetyl-penicillamine, and 8-bromo-cGMP.

Negative_regulation (abolished) of GCs

1) Confidence 0.27 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11408281 Disease Relevance 0 Pain Relevance 0.50

Constitutive release of nitric oxide from enteric neurons sustains cGMP synthesis in the colonic smooth muscle to suppress spontaneous in vitro GCs.

Negative_regulation (suppress) of GCs in smooth muscle

2) Confidence 0.27 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11408281 Disease Relevance 0 Pain Relevance 0.38

The GCs were unaffected by hexamethonium, atropine, and antagonists of serotonergic (5-HT(1--4)), histaminergic (H(1--2)), and tachykininergic (NK(1--2)) receptors but enhanced by NK(3) receptor antagonism.

Neg (unaffected) Negative_regulation (unaffected) of GCs associated with antagonist

3) Confidence 0.27 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11408281 Disease Relevance 0 Pain Relevance 0.51

However, NAC is only protective as long as a viable cysteine-driven synthesis of GSH is operative [25] since it is ineffective when the hepatic store of GSH is artificially depleted by a treatment with buthionine sulfoximine, an inhibitor of GCS [18,39].

Negative_regulation (inhibitor) of GCS

4) Confidence 0.21 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994383 Disease Relevance 0.51 Pain Relevance 0.23

Protection by NAC, HYTAU and TAU against APAP-induced liver injury is also a reflection of their ability to prevent the loss of GCS activity to a toxic dose of APAP, an enzyme that plays a crucial role in protecting the liver against hepatotoxic compounds by regulating the de novo synthesis of GSH.

Negative_regulation (loss) of GCS in liver associated with paracetamol and injury

5) Confidence 0.18 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994383 Disease Relevance 0.46 Pain Relevance 0.40

The results summarized in Figure 5, 6, 7 indicate that a toxic dose of APAP lowered the plasma activities of GR, GST and GCS, respectively, and that all the test compounds offered different degrees of protection against such losses.

Negative_regulation (lowered) of GCS in plasma associated with paracetamol

6) Confidence 0.16 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994383 Disease Relevance 0 Pain Relevance 0.76

-GCS knockdown rats [56] or a specific inhibitor of GCS activity such as buthionine sulfoximine [18] and in which hepatotoxicity by APAP was more extensive than in normal or uninhibited animals.

Negative_regulation (inhibitor) of GCS associated with paracetamol and hepatotoxicity

7) Confidence 0.16 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994383 Disease Relevance 0.50 Pain Relevance 0.49

Although there are previous reports about the inhibitory effect of GCs on IFN-?

Negative_regulation (effect) of GCs

8) Confidence 0.10 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0 Pain Relevance 0.09

General Comments

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