INT96366

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.38
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 0.23
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (Ugcg) Golgi apparatus (Ugcg)
Anatomy Link Frequency
liver 1
muscle 1
Ugcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 334 98.50 Very High Very High Very High
tetrodotoxin 4 94.88 High High
conotoxin 1 92.80 High High
Dopamine 1 88.48 High High
antagonist 2 86.64 High High
Analgesic 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 38 84.16 Quite High
Injury 44 37.12 Quite Low
Stress 36 17.60 Low Low
Overdose 24 5.00 Very Low Very Low Very Low
Toxicity 8 5.00 Very Low Very Low Very Low
Necrosis 8 5.00 Very Low Very Low Very Low
Decapitation 8 5.00 Very Low Very Low Very Low
Diabetes Mellitus 4 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The circular muscle strips generated spontaneous GCs.
Gene_expression (generated) of GCs in muscle
1) Confidence 0.38 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11408281 Disease Relevance 0 Pain Relevance 0.42
The GCS activity of the sample was expressed in U/min/mg of protein, where one unit is defined as the amount of enzyme catalyzing the consumption of 1 ┬ÁM of NADH/min/mg of protein under the assay conditions used.


Gene_expression (expressed) of GCS
2) Confidence 0.28 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994383 Disease Relevance 0 Pain Relevance 0
The effect of APAP, alone and in combination with a sulfur-containing compound, on the liver activities of GR, GST and GCS
Gene_expression (activities) of GCS in liver associated with paracetamol
3) Confidence 0.28 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994383 Disease Relevance 0 Pain Relevance 0.55
Assay of GCS activity
Gene_expression (activity) of GCS
4) Confidence 0.25 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994383 Disease Relevance 0 Pain Relevance 0
On the other hand, a toxic dose of APAP lowered the hepatic activities of those enzymes involved either in de novo synthesis of GSH (i.e., GCS), GSH nucleophilic addition to substrates with electrophilic functional groups (i.e., GST) or in the redox cycling of GSH and GSSG (i.e., GR).
Gene_expression (synthesis) of GCS associated with paracetamol
5) Confidence 0.22 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994383 Disease Relevance 0.07 Pain Relevance 0.38
Furthermore, the activity of y-glutamylcysteine synthetase (gamma-GCS), the rate-limiting enzyme in GSH biosynthesis, was also increased by DCE-GS triester treatment (1.4-fold in 24 h with 1.0 mm).
Gene_expression (biosynthesis) of gamma-GCS
6) Confidence 0.12 Published 2001 Journal Biol. Pharm. Bull. Section Abstract Doc Link 11456112 Disease Relevance 0.16 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox