INT96372

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Context Info
Confidence 0.45
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.22
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gabbr2) plasma membrane (Gabbr2) cytoplasm (Gabbr2)
signal transducer activity (Gabbr2)
Anatomy Link Frequency
melanotrope 1
Gabbr2 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 17 100.00 Very High Very High Very High
Calcium channel 2 97.74 Very High Very High Very High
agonist 4 96.96 Very High Very High Very High
Gabapentin 12 96.32 Very High Very High Very High
Glutamate 4 94.44 High High
antagonist 2 90.56 High High
Antinociceptive 1 87.20 High High
Antihyperalgesic 2 86.36 High High
anticonvulsant 2 85.64 High High
Potency 1 82.00 Quite High
Disease Link Frequency Relevance Heat
Nociception 3 84.40 Quite High
Pain 8 75.44 Quite High
Targeted Disruption 12 63.44 Quite High
Depression 9 5.00 Very Low Very Low Very Low
Sprains And Strains 5 5.00 Very Low Very Low Very Low
Aggression 2 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Ganglion Cysts 1 5.00 Very Low Very Low Very Low
Inflammatory Pain 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mutation of the PDZ-binding motif in GABABR2 results in decrease of surface-expressed GABABR2, indicating the stability and signalling of GABAB receptor is modulated via interactions with Pdzd2.
Gene_expression (expressed) of GABABR2
1) Confidence 0.45 Published 2009 Journal Mol Cell Neurosci Section Body Doc Link PMC2764382 Disease Relevance 0.22 Pain Relevance 0.14
It was suggested that GABABR suppresses the RP induction by reducing the amount of cAMP and the PKA activity by Gi-mediated inhibition of adenylyl cyclase (Kawaguchi and Hirano, 2000).
Gene_expression (suppresses) of GABABR
2) Confidence 0.21 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
In this study, we show that gabapentin (EC50 2 microM) inhibited up to 70 to 80% of the total K+-evoked Ca2+ influx via voltage-dependent calcium channels (VD-CCs) in a mouse pituitary intermediate melanotrope clonal mIL-tsA58 (mIL) cell line. mIL cells endogenously express only gamma-aminobutyric acid type B (GABA(B)) gb1a-gb2 receptors.
Gene_expression (express) of gb1a-gb2 in melanotrope associated with gaba, calcium channel and gabapentin
3) Confidence 0.10 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11408520 Disease Relevance 0 Pain Relevance 1.20
Indeed, it has been shown that GABAbR-1 and GABAbR-2 function as heterodimers.
Gene_expression (function) of GABAbR-2
4) Confidence 0.06 Published 2003 Journal Genome Biol Section Body Doc Link PMC193622 Disease Relevance 0 Pain Relevance 0.08

General Comments

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