INT96404

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Context Info
Confidence 0.69
First Reported 2001
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.25
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Olr1746)
Anatomy Link Frequency
neurons 1
brain 1
Olr1746 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 8 98.32 Very High Very High Very High
agonist 6 97.20 Very High Very High Very High
Trigeminal ganglion neurons 1 94.60 High High
neuropeptide release 1 85.60 High High
Neurotransmitter 1 84.76 Quite High
Triptan 1 81.24 Quite High
Migraine 2 80.92 Quite High
depression 1 76.56 Quite High
Action potential 3 51.68 Quite High
Hippocampus 24 40.52 Quite Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 1 94.28 High High
Headache 2 80.92 Quite High
Depression 1 76.56 Quite High
Urological Neuroanatomy 6 5.00 Very Low Very Low Very Low
Hypersensitivity 2 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further support for the hypothesis that the dADP is mediated by TRPC4 or 5 channels comes from patch-clamp recordings in brain regions where TRPC4 or 5 mRNA was not detected.
Neg (not) Transcription (detected) of or 5 in brain
1) Confidence 0.69 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0.08 Pain Relevance 0.09
The majority of 5-HT1B, 5-HT1D or 5-HT1F receptor positive neurons were also glutamate positive, but both 5-HT1B, 5-HT1D or 5-HT1F receptor single-labeled and glutamate single-labeled neurons were observed.
Transcription (majority) of or 5 in neurons associated with glutamate
2) Confidence 0.67 Published 2001 Journal Neuroreport Section Abstract Doc Link 11409721 Disease Relevance 0.18 Pain Relevance 0.81

General Comments

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