INT96406

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Context Info
Confidence 0.62
First Reported 2001
Last Reported 2010
Negated 4
Speculated 2
Reported most in Abstract
Documents 14
Total Number 18
Disease Relevance 7.45
Pain Relevance 12.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpv2) intracellular (Trpv2) transmembrane transport (Trpv2)
cytoplasm (Trpv2)
Anatomy Link Frequency
spinal cord 2
sympathetic 2
DRG 2
larynx 2
cranial 1
Trpv2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
vanilloid receptor subtype 1 15 100.00 Very High Very High Very High
Osm-9-like TRP channel 2 9 100.00 Very High Very High Very High
agonist 53 99.84 Very High Very High Very High
dorsal root ganglion 48 99.68 Very High Very High Very High
Spinal cord 35 99.48 Very High Very High Very High
qutenza 83 99.00 Very High Very High Very High
medulla 14 98.84 Very High Very High Very High
Calcitonin gene-related peptide 9 98.84 Very High Very High Very High
Root ganglion neuron 70 98.66 Very High Very High Very High
spinal dorsal horn 1 98.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 122 99.68 Very High Very High Very High
Renal Disease 9 98.48 Very High Very High Very High
Neuropathic Pain 20 97.88 Very High Very High Very High
Nociception 3 97.24 Very High Very High Very High
Disease 7 96.16 Very High Very High Very High
Injury 7 95.20 Very High Very High Very High
Peripheral Neuropathy 7 92.32 High High
Pain 20 83.24 Quite High
INFLAMMATION 7 83.24 Quite High
Nervous System Injury 7 81.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to determine whether TRPV2, like TRPV1, is regulated by peripheral axotomy, we performed L5 SpNL and characterized TRPV2 distribution in the DRG, spinal cord, brainstem, and sympathetic ganglia.
Regulation (regulated) of TRPV2 in brainstem associated with medulla, dorsal root ganglion and spinal cord
1) Confidence 0.62 Published 2004 Journal Brain Res. Section Abstract Doc Link 15261111 Disease Relevance 0.87 Pain Relevance 0.88
Regulation of TRPV2 by axotomy in sympathetic, but not sensory neurons.
Regulation (Regulation) of TRPV2 in sympathetic
2) Confidence 0.62 Published 2004 Journal Brain Res. Section Title Doc Link 15261111 Disease Relevance 0.74 Pain Relevance 0.58
Our results show that peripheral axotomy did not regulate TRPV2 in the DRG, spinal cord, or brainstem; however, TRPV2 was up-regulated in sympathetic postganglionic neurons following injury, suggesting a potential role for TRPV2 in sympathetically mediated neuropathic pain.
Neg (not) Regulation (regulate) of TRPV2 in DRG associated with medulla, dorsal root ganglion, injury, neuropathic pain and spinal cord
3) Confidence 0.62 Published 2004 Journal Brain Res. Section Abstract Doc Link 15261111 Disease Relevance 0.78 Pain Relevance 0.80
TRPV2 desensitization was not altered in whole-cell recordings in the presence of calmodulin inhibitors or on coexpression of mutant calmodulin but was sensitive to changes in membrane phosphatidylinositol 4,5-bisphosphate (PIP(2)), suggesting a role of membrane PIP(2) in TRPV2 desensitization.
Neg (not) Regulation (altered) of TRPV2
4) Confidence 0.51 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20926660 Disease Relevance 0.08 Pain Relevance 0.12
Immunoreactivity for vanilloid receptor subtype 1 (VR1) and its analogue vanilloid receptor-like protein 1 (VRL1) were examined in combination with immunoreactivity for substance P (SP) and calcitonin gene-related peptide (CGRP) in the rat larynx.
Spec (examined) Regulation (Immunoreactivity) of vanilloid receptor-like protein 1 in larynx associated with vanilloid receptor subtype 1, osm-9-like trp channel 2, calcitonin gene-related peptide and substance p
5) Confidence 0.44 Published 2005 Journal Auton Neurosci Section Abstract Doc Link 15620571 Disease Relevance 0 Pain Relevance 1.05
Immunoreactivity for vanilloid receptor subtype 1 (VR1) and its analogue vanilloid receptor-like protein 1 (VRL1) were examined in combination with immunoreactivity for substance P (SP) and calcitonin gene-related peptide (CGRP) in the rat larynx.
Spec (examined) Regulation (Immunoreactivity) of VRL1 in larynx associated with vanilloid receptor subtype 1, osm-9-like trp channel 2, calcitonin gene-related peptide and substance p
6) Confidence 0.44 Published 2005 Journal Auton Neurosci Section Abstract Doc Link 15620571 Disease Relevance 0 Pain Relevance 1.06
In juvenile rat dorsal root ganglion neurons, prolonged citral inhibition of native TRPV1 channels enabled the separation of TRPV2 and TRPV3 currents.
Regulation (separation) of TRPV2 in neurons associated with ganglion cysts and root ganglion neuron
7) Confidence 0.29 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2346451 Disease Relevance 0.29 Pain Relevance 0.43
VRL-1 immunoreactivity in the rat cranial autonomic ganglia.
Regulation (immunoreactivity) of VRL-1 in cranial
8) Confidence 0.27 Published 2001 Journal Neuroreport Section Title Doc Link 11409723 Disease Relevance 0.08 Pain Relevance 0.10
Dense VRL1 immunoreactivity was also found in laminae I and II of the spinal dorsal horn, where nociceptive Adelta- and C-fibers normally terminate.
Regulation (immunoreactivity) of VRL1 in dorsal horn associated with nociception, c fibre, adelta and spinal dorsal horn
9) Confidence 0.27 Published 2001 Journal Neuroreport Section Abstract Doc Link 11726776 Disease Relevance 0.10 Pain Relevance 0.61
Thus, we present a new pharmacological tool to distinguish between heat responses of TRPV2 and the closely related capsaicin-receptor, TRPV1, which is strongly sensitized by trivalent cations.
Regulation (responses) of TRPV2 associated with qutenza
10) Confidence 0.27 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17596195 Disease Relevance 0.21 Pain Relevance 0.30
VR1 and VRL1 immunoreactivity were observed in the intraepithelial free nerve endings, subepithelial nerve plexus and laryngeal epithelial cells.
Regulation (immunoreactivity) of VRL1 in nerve plexus associated with vanilloid receptor subtype 1 and osm-9-like trp channel 2
11) Confidence 0.27 Published 2005 Journal Auton Neurosci Section Abstract Doc Link 15620571 Disease Relevance 0 Pain Relevance 1.11
In order to determine whether TRPV2, like TRPV1, is regulated by peripheral axotomy, we performed L5 SpNL and characterized TRPV2 distribution in the DRG, spinal cord, brainstem, and sympathetic ganglia.
Regulation (regulated) of TRPV2 in spinal cord associated with medulla, dorsal root ganglion and spinal cord
12) Confidence 0.21 Published 2004 Journal Brain Res. Section Abstract Doc Link 15261111 Disease Relevance 0.87 Pain Relevance 0.88
Our results show that peripheral axotomy did not regulate TRPV2 in the DRG, spinal cord, or brainstem; however, TRPV2 was up-regulated in sympathetic postganglionic neurons following injury, suggesting a potential role for TRPV2 in sympathetically mediated neuropathic pain.
Neg (not) Regulation (regulate) of TRPV2 in spinal cord associated with medulla, dorsal root ganglion, injury, neuropathic pain and spinal cord
13) Confidence 0.21 Published 2004 Journal Brain Res. Section Abstract Doc Link 15261111 Disease Relevance 0.78 Pain Relevance 0.80
In order to determine whether TRPV2, like TRPV1, is regulated by peripheral axotomy, we performed L5 SpNL and characterized TRPV2 distribution in the DRG, spinal cord, brainstem, and sympathetic ganglia.
Regulation (regulated) of TRPV2 in DRG associated with medulla, dorsal root ganglion and spinal cord
14) Confidence 0.21 Published 2004 Journal Brain Res. Section Abstract Doc Link 15261111 Disease Relevance 0.87 Pain Relevance 0.88
In order to determine whether TRPV2, like TRPV1, is regulated by peripheral axotomy, we performed L5 SpNL and characterized TRPV2 distribution in the DRG, spinal cord, brainstem, and sympathetic ganglia.
Regulation (regulated) of TRPV2 in sympathetic associated with medulla, dorsal root ganglion and spinal cord
15) Confidence 0.21 Published 2004 Journal Brain Res. Section Abstract Doc Link 15261111 Disease Relevance 0.87 Pain Relevance 0.88
Citral initially increased the agonist-evoked responses of TRPV1, TRPV2, and TRPV3 (Fig. 2A, B).
Regulation (responses) of TRPV2 associated with agonist
16) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0 Pain Relevance 0.52
Furthermore, surface biotinylation experiments indicated that the relative number of membrane expressed 2-aminoethyldiphenyl borate -activated TRPV2 channels were not altered by citral treatment (data not shown).
Neg (not) Regulation (altered) of TRPV2
17) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0 Pain Relevance 0.12
However, using immunocytochemistry, TRPV1-immunoreactivity was significantly higher and TRPV2-immunoreactivity was significantly lower in PBMC from ESKD patients compared to controls.
Regulation (immunoreactivity) of TRPV2 in PBMC associated with renal disease
18) Confidence 0.04 Published 2009 Journal Biochim. Biophys. Acta Section Abstract Doc Link 19619644 Disease Relevance 0.93 Pain Relevance 0.92

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