INT96407

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Context Info
Confidence 0.50
First Reported 2001
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 1.98
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Agrp)
Anatomy Link Frequency
bands 2
arcuate nucleus 1
internal 1
Agrp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 23 100.00 Very High Very High Very High
Opioid 6 99.80 Very High Very High Very High
Intracerebroventricular 1 99.28 Very High Very High Very High
opioid receptor 5 96.94 Very High Very High Very High
dexamethasone 1 94.60 High High
sodium channel 1 86.56 High High
tetrodotoxin 1 84.72 Quite High
Neuropeptide 6 75.00 Quite High
Kappa opioid receptor 1 75.00 Quite High
Action potential 1 46.32 Quite Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 208 95.40 Very High Very High Very High
Aids-related Complex 44 93.60 High High
Targeted Disruption 20 75.04 Quite High
Appetite Loss 100 75.00 Quite High
Obesity 12 20.12 Low Low
Body Weight 56 5.00 Very Low Very Low Very Low
Weight Gain 18 5.00 Very Low Very Low Very Low
Cancer 12 5.00 Very Low Very Low Very Low
Pulmonary Edema 12 5.00 Very Low Very Low Very Low
INFLAMMATION 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The current results implicate opioid receptors as critical downstream mediators of the potent effects of AgRP to increase food intake but indicate that either micro - or kappa-receptor activation is sufficient for AgRP's effect.
Positive_regulation (sufficient) of AgRP associated with opioid receptor
1) Confidence 0.50 Published 2002 Journal Endocrinology Section Abstract Doc Link 12399421 Disease Relevance 0 Pain Relevance 0.48
Upon fasting POMC gene expression decreases whereas AgRP increases.
Positive_regulation (increases) of AgRP
2) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.24 Pain Relevance 0
In the second experiment, rats received aortic bands or sham operations, and after recovery received i.c.v. injections of either artificial cerebrospinal fluid (aCSF) or the melanocortin antagonist agouti-related protein (AGRP) for 2 weeks.
Positive_regulation (injections) of agouti-related protein in bands associated with antagonist
3) Confidence 0.40 Published 2010 Journal The Journal of Endocrinology Section Abstract Doc Link PMC2887273 Disease Relevance 0.84 Pain Relevance 0.05
In the second experiment, rats received aortic bands or sham operations, and after recovery received i.c.v. injections of either artificial cerebrospinal fluid (aCSF) or the melanocortin antagonist agouti-related protein (AGRP) for 2 weeks.
Positive_regulation (injections) of AGRP in bands associated with antagonist
4) Confidence 0.40 Published 2010 Journal The Journal of Endocrinology Section Abstract Doc Link PMC2887273 Disease Relevance 0.84 Pain Relevance 0.05
Based on these data we speculate that opioid peptides suppress alpha-MSH-dependent satiety mechanisms; conversely, it is possible that the orexigenic action of Agrp is mediated via opioid dependent circuitry.
Spec (possible) Positive_regulation (mediated) of Agrp associated with opioid
5) Confidence 0.29 Published 2001 Journal Neuroreport Section Abstract Doc Link 11409748 Disease Relevance 0 Pain Relevance 0.51
Total RNA (1 µg) isolated (Trizol Reagent, Invitrogen) from fresh arcuate nucleus tissue was converted to cDNA and used to screen expression levels of Sirt1, POMC, AgRP, and tubulin (internal control).
Positive_regulation (screen) of AgRP in internal
6) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.07 Pain Relevance 0
Glucocorticoids were also necessary for ghrelin action in vivo because an intracerebroventricular injection of ghrelin significantly increased NPY and AGRP mRNA expression in the arcuate nucleus only in sham-operated, but not in adrenalectomized rats.
Neg (not) Positive_regulation (increased) of AGRP mRNA in arcuate nucleus associated with intracerebroventricular
7) Confidence 0.15 Published 2006 Journal Endocrinology Section Abstract Doc Link 16887908 Disease Relevance 0 Pain Relevance 0.30

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