INT96416

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Context Info
Confidence 0.02
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.96
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CYC1, Casp3) cytoplasm (CYC1, Casp3) transport (CYC1)
small molecule metabolic process (CYC1) intracellular (Casp3) cytosol (Casp3)
CYC1 (Homo sapiens)
Casp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 3 61.12 Quite High
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 7 98.62 Very High Very High Very High
Esophageal Cancer 3 75.00 Quite High
Cancer 3 72.48 Quite High
INFLAMMATION 1 51.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Altogether, our data suggest that induction of apoptosis by NS398 is associated with COX-2 expression and occurs through the cytochrome c-dependent pathway, which sequentially activates caspase-9 and caspase-3 and cleaves PARP.
cytochrome c Positive_regulation (activates) of caspase-3 associated with apoptosis
1) Confidence 0.02 Published 2001 Journal Int. J. Cancer Section Abstract Doc Link 11410869 Disease Relevance 0.96 Pain Relevance 0.17

General Comments

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