INT96422

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Context Info
Confidence 0.69
First Reported 2001
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 3.26
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Bmp4) anatomical structure formation involved in morphogenesis (Bmp4) extracellular space (Bmp4)
growth (Bmp4) extracellular region (Bmp4) proteinaceous extracellular matrix (Bmp4)
Anatomy Link Frequency
skeletal muscles 2
neural 2
chondrocytes 1
fibroblast 1
Bmp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fifth nerve 4 93.40 High High
Trigeminal neuralgia 4 89.40 High High
Central nervous system 28 78.96 Quite High
Peripheral nervous system 1 77.44 Quite High
Spinal cord 87 58.28 Quite High
agonist 7 52.32 Quite High
allodynia 22 50.00 Quite Low
Pain 14 39.76 Quite Low
Kinase C 2 33.40 Quite Low
Neuropathic pain 18 27.48 Quite Low
Disease Link Frequency Relevance Heat
Osteoporosis 45 99.46 Very High Very High Very High
Neurilemmoma 6 98.78 Very High Very High Very High
Malignant Neoplastic Disease 4 98.60 Very High Very High Very High
Diabetes Mellitus 50 95.60 Very High Very High Very High
Headache 4 89.40 High High
Cicatrix 12 88.52 High High
Calcification 30 87.68 High High
Injury 149 83.76 Quite High
Overdose 15 78.04 Quite High
Nerve Sheath Neoplasms 4 76.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, since isolated neural stem cells exposed to glucose in vitro show increased gene expression of both Shh and Bmp-4 (50), the exact relationship(s) between gene expression changes in the surrounding tissues and the neural crest cells themselves caused by exposure to a diabetic environment will have be subject to further studies.
Gene_expression (expression) of Bmp-4 in neural associated with diabetes mellitus
1) Confidence 0.69 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.47 Pain Relevance 0
In agreement with previous observations of the effects of BMP on Olig2 expression in cortical neural progenitors [19], GRPs exposed to BMP-4 downregulated Olig2 expression (Figure 3a).
Gene_expression (expression) of BMP-4 in neural
2) Confidence 0.33 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 0.28 Pain Relevance 0.09
Rat BMP-4 mRNA expression was weak in the BMP-2 and in the BMP-7 single-gene transfer groups.


Gene_expression (expression) of BMP-4 mRNA
3) Confidence 0.27 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.07 Pain Relevance 0
In the group treated with the combined BMP-2 and BMP-7 genes, rat BMP-4 mRNA was expressed, and its level increased up to 3 days after gene transfer in a time-dependent manner.
Gene_expression (expressed) of BMP-4 mRNA
4) Confidence 0.27 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.08 Pain Relevance 0
In the costochondral growth-plate chondrocytes, BMP-2 induces the expression of BMP-4 mRNA in a cell maturation-dependent manner [12].
Gene_expression (expression) of BMP-4 mRNA in chondrocytes
5) Confidence 0.27 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.08 Pain Relevance 0
On the other hand, BMP-2 inhibits BMP-4 mRNA expression initially, but stimulates it during the mineralization phase [11,13].
Gene_expression (expression) of BMP-4 mRNA
6) Confidence 0.27 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.07 Pain Relevance 0
Endogenous BMP-4 mRNA was highly expressed in the skeletal muscle of rats receiving the pCAGGS-BMP-2 and pCAGGS-BMP-7 genes, but its expression was much weaker in the skeletal muscles of rats receiving only one of the genes.
Gene_expression (expressed) of BMP-4 mRNA in skeletal muscles
7) Confidence 0.27 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0 Pain Relevance 0
Under conditions of normal osteoblastic cell differentiation, rat BMP-4 mRNA is expressed in the early phase with peak expression levels during the proliferation and matrix formation phases, but it declines afterwards in FRC cells [10,23].
Gene_expression (expressed) of BMP-4 mRNA associated with osteoporosis
8) Confidence 0.27 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.10 Pain Relevance 0
Expression of rat endogenous BMP-4 mRNA
Gene_expression (Expression) of BMP-4 mRNA
9) Confidence 0.27 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.09 Pain Relevance 0
Moreover, BMP-4 mRNA is detected in areas where fibroblast-like cells and preosteoblasts migrate, in the early stage of distraction osteogenesis [28].
Gene_expression (detected) of BMP-4 mRNA in fibroblast
10) Confidence 0.27 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.09 Pain Relevance 0
For immunohistochemical detection of BMP-4, serial sections were rehydrated and immersed in 0.5% periodic acid solution for 10 min to eliminate the non-specific reaction by endogenous peroxidase, then incubated in PBS containing 10% bovine serum albumin for 15 min, and washed with PBS.
Gene_expression (detection) of BMP-4
11) Confidence 0.24 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.08 Pain Relevance 0
The simultaneous transfer of BMP-2 and BMP-7 genes using in vivo electroporation induces more rapid bone formation than the transfer of either gene alone, and the increased expression of endogenous BMP-4 suggests that the rapid ossification is related to the induction of BMP-4.



Gene_expression (expression) of BMP-4
12) Confidence 0.21 Published 2006 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC1557501 Disease Relevance 0 Pain Relevance 0
BMP-4 mRNA was also expressed, and RT-PCR showed that its level increased for 3 days in a time-dependent manner in the double-gene transfer group.
Gene_expression (expressed) of BMP-4 mRNA
13) Confidence 0.21 Published 2006 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC1557501 Disease Relevance 0 Pain Relevance 0
Simultaneous gene transfer of bone morphogenetic protein (BMP) -2 and BMP-7 by in vivo electroporation induces rapid bone formation and BMP-4 expression

Background

Gene_expression (expression) of BMP-4
14) Confidence 0.21 Published 2006 Journal BMC Musculoskelet Disord Section Title Doc Link PMC1557501 Disease Relevance 0 Pain Relevance 0
Therefore, the expression of BMP-4 mRNA and its increase in the early phase might be involved with the effective bone formation seen when the BMP-2 and BMP-7 genes were simultaneously transferred into rat skeletal muscles by transcutaneous in vivo electroporation.
Gene_expression (expression) of BMP-4 mRNA in skeletal muscles
15) Confidence 0.21 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.17 Pain Relevance 0
In addition, the endogenous BMP-4 mRNA expression levels and BMP-4-expressing cells were examined, since several reports show that exogenous BMPs elevate the levels of other BMPs or BMP-4 mRNA [11-14].
Spec (examined) Gene_expression (expression) of BMP-4-expressing
16) Confidence 0.21 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.06 Pain Relevance 0
In addition, the endogenous BMP-4 mRNA expression levels and BMP-4-expressing cells were examined, since several reports show that exogenous BMPs elevate the levels of other BMPs or BMP-4 mRNA [11-14].
Gene_expression (expression) of BMP-4 mRNA
17) Confidence 0.21 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.06 Pain Relevance 0
The expression signals of BMP-2, 3, 5 mRNA in malignant schwannoma were relatively lower than in benign lesions except for the expression of BMP-4 mRNA.
Neg (except) Gene_expression (expression) of BMP-4 mRNA associated with malignant neoplastic disease and neurilemmoma
18) Confidence 0.02 Published 2001 Journal Histol. Histopathol. Section Abstract Doc Link 11642720 Disease Relevance 0.73 Pain Relevance 0.28
Except for the BMP-4 mRNA, the expression signals of BMP-2, 3 and 5 mRNA in malignant schwannoma were relatively lower than in benign lesions.
Gene_expression (expression) of BMP-4 mRNA associated with malignant neoplastic disease and neurilemmoma
19) Confidence 0.02 Published 2001 Journal Kaohsiung J. Med. Sci. Section Abstract Doc Link 11411255 Disease Relevance 0.83 Pain Relevance 0.26

General Comments

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