INT96423

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 61
Total Number 62
Disease Relevance 25.07
Pain Relevance 3.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Bmp2) growth (Bmp2) extracellular region (Bmp2)
embryo development (Bmp2) protein complex (Bmp2) cytoplasm (Bmp2)
Anatomy Link Frequency
tendon 5
skeletal muscles 4
chondrocyte 3
epithelial cells 3
SFs 3
Bmp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Trigeminal neuralgia 10 99.66 Very High Very High Very High
antagonist 23 99.58 Very High Very High Very High
spinal inflammation 26 98.76 Very High Very High Very High
cytokine 2 97.64 Very High Very High Very High
fifth nerve 10 96.56 Very High Very High Very High
Osteoarthritis 4 95.92 Very High Very High Very High
Snapping jaw 4 95.40 Very High Very High Very High
Myofascial pain syndrome 4 94.08 High High
Pain 25 84.00 Quite High
anesthesia 71 77.76 Quite High
Disease Link Frequency Relevance Heat
Headache 10 99.66 Very High Very High Very High
Malignant Neoplastic Disease 10 99.40 Very High Very High Very High
Tendon Injuries 207 99.16 Very High Very High Very High
Arthritis 27 99.12 Very High Very High Very High
Cancer 26 99.12 Very High Very High Very High
Injury 370 99.06 Very High Very High Very High
Neurilemmoma 15 99.00 Very High Very High Very High
Osteoporosis 146 98.84 Very High Very High Very High
Low Back Pain 28 98.76 Very High Very High Very High
Calcification 695 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Arthritic synovial membranes have also been shown to express BMP-2 & BMP-6 and could influence cell turnover [13].
Gene_expression (express) of BMP-2 associated with arthritis
1) Confidence 0.78 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2725034 Disease Relevance 0.39 Pain Relevance 0
The expression of BMP-2 was normalized to the expression of ?
Gene_expression (expression) of BMP-2
2) Confidence 0.78 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2725034 Disease Relevance 0.06 Pain Relevance 0
As we observed earlier expression of BMP-2 mRNA and protein at week 2 in healing tendon cells, before the time of its appearance in chondrocyte-like cells and calcific deposits, this also supported that calcific tendon degeneration is mediated by the healing tendon cells which have plasticity and are under erroneous cell differentiation due to the changes in the mechanical and biological microenvironment.
Gene_expression (expression) of BMP-2 mRNA in tendon associated with calcification
3) Confidence 0.78 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2725034 Disease Relevance 0.67 Pain Relevance 0
BMP-2 protein was detected in the chondrocyte-like cells and calcific deposits in both injury models but not in control samples, indicating that BMP-2 might be involved in the pathogenesis of ectopic chondrogenesis and ossification.
Gene_expression (detected) of BMP-2 protein in chondrocyte associated with calcification and injury
4) Confidence 0.78 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2725034 Disease Relevance 1.14 Pain Relevance 0.06
We observed lower level of expression of BMP-2 at similar chondrogenic and ossification sites in the traumatic tendon injury model.
Gene_expression (expression) of BMP-2 in tendon associated with tendon injuries
5) Confidence 0.78 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2725034 Disease Relevance 0.39 Pain Relevance 0
(Lui Cheuk YC, Fu SC, Chan KM: Chondrometaplasia and Ossification During Repair of Patella Tendon Injury, submitted) We hypothesized that ectopic expression of BMP-2 might be involved in the chondrometaplasia and ossification in both models.
Gene_expression (expression) of BMP-2 in Tendon associated with tendon injuries
6) Confidence 0.78 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2725034 Disease Relevance 1.19 Pain Relevance 0.07
The expression of BMP-2 in the chondrocyte-like cells and calcific deposits suggested that BMP-2 might be involved in ectopic chondrogenesis and ossification.
Gene_expression (expression) of BMP-2 in chondrocyte associated with calcification
7) Confidence 0.78 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2725034 Disease Relevance 1.01 Pain Relevance 0
Regarding the possible changes in mechanical and biological microenvironment that cause the ectopic expression of BMP-2 in tendons, it is currently not clear.
Gene_expression (expression) of BMP-2 in tendons
8) Confidence 0.78 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2725034 Disease Relevance 0.40 Pain Relevance 0
All of the neoplastic lesions of nerve sheath showed a consistent but variant expression of BMP-2, 3, 4, and 5.
Gene_expression (expression) of BMP-2 in nerve
9) Confidence 0.74 Published 2001 Journal Histol. Histopathol. Section Abstract Doc Link 11642720 Disease Relevance 0.76 Pain Relevance 0.29
The expression signals of BMP-2, 3, 5 mRNA in malignant schwannoma were relatively lower than in benign lesions except for the expression of BMP-4 mRNA.
Gene_expression (expression) of BMP-2 associated with malignant neoplastic disease and neurilemmoma
10) Confidence 0.74 Published 2001 Journal Histol. Histopathol. Section Abstract Doc Link 11642720 Disease Relevance 0.76 Pain Relevance 0.29
All of the neoplastic lesions of nerve sheath showed a consistent but variant expression of BMP-2, 3, 4, and 5.
Gene_expression (expression) of BMP-2 in nerve
11) Confidence 0.73 Published 2001 Journal Kaohsiung J. Med. Sci. Section Abstract Doc Link 11411255 Disease Relevance 0.83 Pain Relevance 0.26
No immunopositivity of BMP-2 was observed in both control groups (Figure 1A and 1F).
Gene_expression (immunopositivity) of BMP-2
12) Confidence 0.67 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2725034 Disease Relevance 0.40 Pain Relevance 0
Our results demonstrated that the myelin sheaths of schwann cell from the peripheral neuroectomy of trigeminal neuralgia were positively expressing mRNA of BMP-2, 3, 4 and 5.
Gene_expression (expressing) of BMP-2 in schwann cell associated with trigeminal neuralgia
13) Confidence 0.63 Published 2001 Journal Kaohsiung J. Med. Sci. Section Abstract Doc Link 11411255 Disease Relevance 0.86 Pain Relevance 0.28
Except for the BMP-4 mRNA, the expression signals of BMP-2, 3 and 5 mRNA in malignant schwannoma were relatively lower than in benign lesions.
Gene_expression (expression) of BMP-2 associated with malignant neoplastic disease and neurilemmoma
14) Confidence 0.63 Published 2001 Journal Kaohsiung J. Med. Sci. Section Abstract Doc Link 11411255 Disease Relevance 0.83 Pain Relevance 0.25
Expression of Bone Morphogenetic Protein-2 in the Chondrogenic and Ossifying Sites of Calcific Tendinopathy and Traumatic Tendon Injury Rat Models

Background

Gene_expression (Expression) of Bone Morphogenetic Protein-2 in Tendon associated with calcification, tendon injuries and tendinopathy
15) Confidence 0.60 Published 2009 Journal J Orthop Surg Res Section Title Doc Link PMC2725034 Disease Relevance 0.88 Pain Relevance 0
This study aimed to report the spatial and temporal expression of BMP-2 protein and mRNA in both animal models.


Gene_expression (expression) of BMP-2 protein
16) Confidence 0.60 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2725034 Disease Relevance 0.54 Pain Relevance 0.08
Ectopic expression of BMP-2 might induce tissue transformation into ectopic bone/cartilage and promoted structural degeneration in calcific tendinopathy.



Gene_expression (expression) of BMP-2 in cartilage associated with calcification and tendinopathy
17) Confidence 0.60 Published 2009 Journal J Orthop Surg Res Section Abstract Doc Link PMC2725034 Disease Relevance 0.78 Pain Relevance 0
mRNA expression of BMP-2
Gene_expression (expression) of BMP-2
18) Confidence 0.60 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2725034 Disease Relevance 0.65 Pain Relevance 0
Further studies are required to understand the causes for increased expression of BMP-2 and the role of BMP-2 signaling pathway in tendon cell differentiation and tendon degeneration.


Gene_expression (expression) of BMP-2 in tendon cell
19) Confidence 0.60 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2725034 Disease Relevance 0.75 Pain Relevance 0.04
We hypothesized that expression of bone morphogenetic protein-2 (BMP-2) contributed to ectopic chondrogenesis and ossification.
Gene_expression (expression) of bone morphogenetic protein-2
20) Confidence 0.60 Published 2009 Journal J Orthop Surg Res Section Abstract Doc Link PMC2725034 Disease Relevance 0.67 Pain Relevance 0

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