INT96462

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Context Info
Confidence 0.01
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.74
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pnoc) plasma membrane (Pag1) intracellular (Pag1)
Pnoc (Rattus norvegicus)
Pag1 (Mus musculus)
Pain Link Frequency Relevance Heat
Periaqueductal grey 10 100.00 Very High Very High Very High
opioid receptor 8 100.00 Very High Very High Very High
orphanin 6 100.00 Very High Very High Very High
agonist 4 100.00 Very High Very High Very High
Enkephalin 2 100.00 Very High Very High Very High
analgesia 2 99.72 Very High Very High Very High
Opioid 4 98.52 Very High Very High Very High
mu opioid receptor 6 94.36 High High
antagonist 6 89.40 High High
narcan 8 87.12 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 10 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both orphanin FQ/nociceptin (OFQ/N), an ORL1 agonist, and [D-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin (DAMGO), a mu-opioid receptor agonist, activated inwardly rectifying K+ (Kir) channels in the ventrolateral PAG.
orphanin FQ Positive_regulation (activated) of PAG associated with periaqueductal grey, orphanin, agonist, opioid receptor and enkephalin
1) Confidence 0.01 Published 2001 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 11414652 Disease Relevance 0.37 Pain Relevance 1.23
Both orphanin FQ/nociceptin (OFQ/N), an ORL1 agonist, and [D-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin (DAMGO), a mu-opioid receptor agonist, activated inwardly rectifying K+ (Kir) channels in the ventrolateral PAG.
nociceptin Positive_regulation (activated) of PAG associated with periaqueductal grey, orphanin, agonist, opioid receptor and enkephalin
2) Confidence 0.01 Published 2001 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 11414652 Disease Relevance 0.37 Pain Relevance 1.22

General Comments

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