INT96464

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Context Info
Confidence 0.45
First Reported 2001
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 5.48
Pain Relevance 4.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GEM) plasma membrane (GEM) GTPase activity (GEM)
Anatomy Link Frequency
T cells 2
GEM (Homo sapiens)
Pain Link Frequency Relevance Heat
dorsal root ganglion 164 99.52 Very High Very High Very High
Hyperalgesia 50 99.16 Very High Very High Very High
mu opioid receptor 6 98.56 Very High Very High Very High
Periaqueductal grey 10 96.92 Very High Very High Very High
potassium channel 14 96.48 Very High Very High Very High
rheumatoid arthritis 31 95.76 Very High Very High Very High
hyperexcitability 28 91.44 High High
antagonist 6 90.72 High High
withdrawal 12 86.00 High High
agonist 4 85.00 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 37 99.64 Very High Very High Very High
Ganglion Cysts 186 99.52 Very High Very High Very High
Hyperalgesia 50 99.16 Very High Very High Very High
Hepatitis 2 97.88 Very High Very High Very High
Infection 4 97.16 Very High Very High Very High
Urological Neuroanatomy 10 96.92 Very High Very High Very High
Rheumatoid Arthritis 36 95.76 Very High Very High Very High
Eclampsia 12 95.48 Very High Very High Very High
Disease 22 90.72 High High
Autoimmune Disease 3 87.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that an as yet unidentified adaptor molecule could associate with and stabilize cell surface expression of activating KIR in T cells that do not express DAP12.
Positive_regulation (activating) of KIR in T cells
1) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.31 Pain Relevance 0.15
It is considered that the low population of KIR-expressing cells in T cells might be associated
Positive_regulation (population) of KIR in T cells
2) Confidence 0.27 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804296 Disease Relevance 0.78 Pain Relevance 0.23
When cultured on LN, pool cells expressing FRNK demonstrated a significant increase in Gem-induced apoptosis, compared with parental cells and vector cells (P < 0.05) (Fig. 10A-C).
Positive_regulation (increase) of Gem associated with apoptosis
3) Confidence 0.26 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.40 Pain Relevance 0
Based on these data, we hypothesized that advantageous genetic diversity might enhance not only antigen presentation and recognition (e.g., MHC and KIR), but also earlier steps of the MHC antigen presentation pathway.
Spec (might) Positive_regulation (enhance) of KIR
4) Confidence 0.10 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.47 Pain Relevance 0.13
This has been suggested as an explanation for the highly polymorphic KIR loci [12], with KIR A haplotypes protecting against hepatitis C virus infection but being a risk factor for pre-eclampsia.
Positive_regulation (explanation) of KIR associated with eclampsia, infection and hepatitis
5) Confidence 0.08 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.81 Pain Relevance 0
In contrast, NalBzOH did not affect baclofen-induced activation of Kir channels.
Positive_regulation (activation) of Kir
6) Confidence 0.04 Published 2001 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 11414652 Disease Relevance 0.32 Pain Relevance 1.15
It is concluded that NalBzOH antagonizes the activation of Kir channels mediated by both ORL1 and mu-opioid receptors in the ventrolateral PAG.
Positive_regulation (activation) of Kir associated with periaqueductal grey and mu opioid receptor
7) Confidence 0.03 Published 2001 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 11414652 Disease Relevance 0.39 Pain Relevance 1.11
However, a delayed induction of AdKir failed to alleviate the hyperalgesia caused by CCD (Figure 3B).


Positive_regulation (induction) of AdKir associated with dorsal root ganglion and hyperalgesia
8) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959023 Disease Relevance 1.17 Pain Relevance 0.92
The mechanical hyperalgesia produced by CCD was partially alleviated by immediate, but not delayed, induction of the Kir gene
Neg (not) Positive_regulation (induction) of Kir associated with dorsal root ganglion and hyperalgesia
9) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959023 Disease Relevance 0.84 Pain Relevance 0.68

General Comments

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