INT96467

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Context Info
Confidence 0.10
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.56
Pain Relevance 2.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lamb1) extracellular region (Lamb1) cell adhesion (Lamb1)
proteinaceous extracellular matrix (Lamb1) enzyme binding (Lamb1)
Anatomy Link Frequency
leukocyte 1
Lamb1 (Mus musculus)
Pain Link Frequency Relevance Heat
b2 receptor 34 100.00 Very High Very High Very High
gABA 15 99.98 Very High Very High Very High
cytokine 16 99.80 Very High Very High Very High
Inflammation 48 99.60 Very High Very High Very High
chemokine 40 96.20 Very High Very High Very High
B1 receptor 6 94.12 High High
bradykinin 24 88.04 High High
ischemia 6 85.96 High High
addiction 1 84.36 Quite High
Pain 3 83.44 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 56 99.60 Very High Very High Very High
Multiple Sclerosis 172 91.92 High High
Cv General 4 Under Development 8 85.96 High High
Drug Dependence 1 84.56 Quite High
Spasticity 1 83.92 Quite High
Pain 3 83.44 Quite High
Epilepsy 1 83.04 Quite High
Disease 30 80.40 Quite High
Targeted Disruption 9 80.20 Quite High
Brain Injury 2 77.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fumonisin B1, mycotoxin produced by Fusarium verticillioides, is a reportedly specific inhibitor of ceramide synthase.
Gene_expression (produced) of Fumonisin B1
1) Confidence 0.10 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16960033 Disease Relevance 0 Pain Relevance 0
Epileptogenesis and enhanced prepulse inhibition in GABA(B1)-deficient mice.
Gene_expression (deficient) of B1 associated with gaba
2) Confidence 0.01 Published 2001 Journal Mol. Cell. Neurosci. Section Title Doc Link 11414794 Disease Relevance 0.54 Pain Relevance 0.75
Studies have demonstrated that pro-inflammatory cytokines regulate B1 and B2 receptor expression [11,22,23] and, conversely, blockade of kinins receptors modifies expression of cytokines and chemokines [24,25].
Gene_expression (expression) of B1 associated with chemokine, inflammation, b2 receptor and cytokine
3) Confidence 0.01 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 0.95 Pain Relevance 1.00
The expressed B1 is relevant to the control of CCL5 production and to ensuing leukocyte adherence and tissue inflammation.
Gene_expression (expressed) of B1 in leukocyte associated with inflammation
4) Confidence 0.01 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 1.07 Pain Relevance 0.49

General Comments

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