INT9647

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Context Info
Confidence 0.65
First Reported 1987
Last Reported 2010
Negated 3
Speculated 6
Reported most in Body
Documents 163
Total Number 169
Disease Relevance 89.76
Pain Relevance 26.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PROC) extracellular space (PROC) extracellular region (PROC)
plasma membrane (PROC)
Anatomy Link Frequency
brain 6
monocyte 5
plasma 4
striatum 4
adult brain 3
PROC (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1086 100.00 Very High Very High Very High
cytokine 474 100.00 Very High Very High Very High
palliative 124 100.00 Very High Very High Very High
chemokine 93 100.00 Very High Very High Very High
Dynorphin 17 100.00 Very High Very High Very High
Neuropeptide 12 100.00 Very High Very High Very High
Nerve growth factor 7 100.00 Very High Very High Very High
c fibre 7 99.98 Very High Very High Very High
rheumatoid arthritis 24 99.92 Very High Very High Very High
metalloproteinase 18 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1222 100.00 Very High Very High Very High
Coronary Artery Disease 582 100.00 Very High Very High Very High
Adhesions 292 100.00 Very High Very High Very High
Apoptosis 265 100.00 Very High Very High Very High
Infection 176 100.00 Very High Very High Very High
Pancreatic Cancer 168 100.00 Very High Very High Very High
Pseudomonas Infection 160 100.00 Very High Very High Very High
Pulmonary Disease 75 100.00 Very High Very High Very High
Leukemia 13 100.00 Very High Very High Very High
Pancreatitis 849 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Protein C and Protein S deficiencies are genetic traits predisposing to the formation of venous clots.
Gene_expression (deficiencies) of Protein C
1) Confidence 0.65 Published 2004 Journal Thromb J Section Body Doc Link PMC415559 Disease Relevance 0.73 Pain Relevance 0.12
CT values; representing the raw, normalized data, were used for analyses, also through PROC MIXED.
Spec (analyses) Gene_expression (through) of PROC
2) Confidence 0.65 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2876169 Disease Relevance 0 Pain Relevance 0
Data conformed to a split-plot repeated measures analysis of variance and was analyzed using SAS PROC MIXED.
Spec (analyzed) Gene_expression (using) of SAS PROC
3) Confidence 0.61 Published 2006 Journal Vet Anaesth Analg Section Body Doc Link 17083610 Disease Relevance 0.06 Pain Relevance 0
Data were analyzed using PROC MIXED in SAS.
Spec (analyzed) Gene_expression (using) of PROC MIXED
4) Confidence 0.59 Published 2009 Journal J. Dairy Sci. Section Abstract Doc Link 19164664 Disease Relevance 0.22 Pain Relevance 0.25
Four main themes were identified, related to the following: PC diagnosis, research into disease causation, better consumer and practitioner information about PC, and the quality of pancreatic cancer care.
Gene_expression (diagnosis) of PC associated with pancreatic cancer and disease
5) Confidence 0.54 Published 2010 Journal Cancer Causes Control Section Body Doc Link PMC2855814 Disease Relevance 0.56 Pain Relevance 0
The current correlations between HLA-DR expression and the PC and APC levels may therefore support the concept of interaction between inflammation and the PC pathway.
Gene_expression (expression) of PC associated with inflammation
6) Confidence 0.44 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 1.09 Pain Relevance 0.31
The results of APC and total PC are expressed as a percentage relative to the plasma pool from healthy adults, defined as 100%.
Gene_expression (expressed) of PC in plasma
7) Confidence 0.44 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.14 Pain Relevance 0.07
In severe AP, levels of PC and APC were moderately associated with monocyte activation status.
Gene_expression (levels) of PC in monocyte associated with pancreatitis
8) Confidence 0.44 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 1.14 Pain Relevance 0.28
Production of rheumatoid factors and immunoglobulins, joint counts and questionnaire evaluations were measured 3 to 6 times over a 24-h period of hospitalization in 10 patients with RA who were not receiving steroids or second line drugs.
Gene_expression (Production) of factors in joint associated with rheumatoid arthritis
9) Confidence 0.43 Published 1993 Journal J. Rheumatol. Section Abstract Doc Link 8350328 Disease Relevance 0.85 Pain Relevance 0.35
Temporary hemostasis can be obtained by embolization of side-branches of the IIA combined with the placement of an angioplasty balloon in the CIA and EIA crossing the ostium of the IIA.
Gene_expression (crossing) of IIA
10) Confidence 0.43 Published 2007 Journal Cardiovasc Intervent Radiol Section Body Doc Link PMC1964782 Disease Relevance 0.73 Pain Relevance 0.17
The current observational study of the course of PC and APC levels during AP in 31 patients with a 42% incidence of MOF was conducted to address how often and to what extent the PC pathway would be disturbed and whether such perturbations would be associated with the development of MOF.
Gene_expression (levels) of PC associated with multiple organ failure and pancreatitis
11) Confidence 0.38 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.48 Pain Relevance 0
Namely, there was no indication that PC deficiency would associate with MOF after its diagnosis and, further, there was a significant trend for improvement of PC homeostasis during the course of MOF.
Gene_expression (deficiency) of PC associated with multiple organ failure
12) Confidence 0.38 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 1.55 Pain Relevance 0.03
Low PC was found to precede MOF, and early APC/PC ratios were frequently high in MOF patients.
Gene_expression (precede) of PC associated with multiple organ failure
13) Confidence 0.38 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 1.06 Pain Relevance 0
During the first 2 weeks of hospitalization, 92% of cases and 50% of controls had APC/PC ratios exceeding the upper normal limit (P = 0.020).
Gene_expression (ratios) of PC in upper
14) Confidence 0.38 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.22 Pain Relevance 0
H. pylori virulence factors promote release of a variety of chemoattractants/inflammatory mediators.
Gene_expression (promote) of factors associated with inflammatory mediators
15) Confidence 0.37 Published 2001 Journal Hepatogastroenterology Section Abstract Doc Link 11462918 Disease Relevance 0.92 Pain Relevance 0.31
Blood samples were drawn every second day to determine the platelet count, the levels of APC, PC, and D-dimer, and the monocyte HLA-DR expression using flow cytometry.
Gene_expression (levels) of PC in monocyte
16) Confidence 0.34 Published 2006 Journal Crit Care Section Abstract Doc Link PMC1550818 Disease Relevance 0.96 Pain Relevance 0
We therefore evaluated circulating levels of PC and activated protein C (APC), evaluated monocyte deactivation in AP patients, and determined the relationship of these parameters to MOF.


Gene_expression (levels) of PC in monocyte associated with multiple organ failure and pancreatitis
17) Confidence 0.34 Published 2006 Journal Crit Care Section Abstract Doc Link PMC1550818 Disease Relevance 0.99 Pain Relevance 0
Blood samples were drawn every second day to determine the platelet count, the levels of APC, PC, and D-dimer, and the monocyte HLA-DR expression using flow cytometry.
Gene_expression (expression) of PC in monocyte
18) Confidence 0.34 Published 2006 Journal Crit Care Section Abstract Doc Link PMC1550818 Disease Relevance 1.01 Pain Relevance 0
Thus trapidil, a new antianginal agent appears to inhibit the production of platelet derived growth factors and may, therefore, protect the arteries from atherosclerosis as it promotes beneficial systemic hemodynamics in patients with depressed ventricular function.
Gene_expression (production) of factors in platelet associated with increased venous pressure under development
19) Confidence 0.33 Published 1991 Journal Jpn Heart J Section Abstract Doc Link 1833567 Disease Relevance 0.44 Pain Relevance 0.18
During this 10-day period both the APC and the PC levels tended to increase (Figure 3a,b).
Gene_expression (levels) of PC
20) Confidence 0.33 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.30 Pain Relevance 0

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