INT9648

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Context Info
Confidence 0.59
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 11.31
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (LPA) transport (LPA) small molecule metabolic process (LPA)
extracellular region (LPA) lipid metabolic process (LPA)
Anatomy Link Frequency
plasma 2
endothelial cells 2
neural tube 2
neurons 2
platelet 2
LPA (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 25 99.56 Very High Very High Very High
cva 4 89.20 High High
Multiple sclerosis 82 84.20 Quite High
Potency 5 65.52 Quite High
agonist 43 64.36 Quite High
Clonidine 7 62.80 Quite High
cINOD 6 55.28 Quite High
c fibre 1 50.00 Quite Low
Cancer pain 1 50.00 Quite Low
aspirin 7 49.20 Quite Low
Disease Link Frequency Relevance Heat
Cardiovascular Disease 51 99.90 Very High Very High Very High
Arrhythmias 2 Under Development 128 99.84 Very High Very High Very High
Cv General 3 Under Development 26 99.56 Very High Very High Very High
Brain Hemorrhage 129 99.08 Very High Very High Very High
Myocardial Infarction 37 98.88 Very High Very High Very High
Atherosclerosis 33 98.40 Very High Very High Very High
Disorder Of Lipid Metabolism 62 98.16 Very High Very High Very High
Exencephaly /

Neural Tube Defects

9 97.88 Very High Very High Very High
Atherosclerotic Plaque 7 97.80 Very High Very High Very High
Thrombophilia 5 97.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several changes were observed at this time point including: ipsilateral dorsal root ganglion (DRG) neurons were labeled by injured neurons marker ATF3; LPA(1) receptor expression in DRG neurons was increased; sural C-fibers were more sensitive to LPA stimuli, and this response could be blocked by LPA receptor and substance P receptor antagonists.
Positive_regulation (increased) of Gene_expression (expression) of LPA in neurons
1) Confidence 0.59 Published 2010 Journal Life Sci. Section Body Doc Link 20553953 Disease Relevance 0.08 Pain Relevance 0
Platelets contribute to the production of LPA [8], which has been proposed to be a primary lipid in atherosclerotic plaque that is responsible for platelet activation [9].
Positive_regulation (contribute) of Gene_expression (production) of LPA in platelet associated with atherosclerotic plaque
2) Confidence 0.55 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996775 Disease Relevance 1.35 Pain Relevance 0
Based on their serum Lp(a) levels, patients were classified into tertiles as follows: Tertile 1 (n=276), Lp(a)<13.8 mg/dL; Tertile 2 (n=279), Lp(a)=13.8-30.6 mg/dL; and Tertile 3 (n=277), Lp(a)?
Positive_regulation (serum) of Gene_expression (levels) of Lp
3) Confidence 0.50 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978291 Disease Relevance 1.20 Pain Relevance 0.17
RESULTS: No association was observed between elevated Lp(a) levels alone and any of the examined vascular diseases (stroke, myocardial infarction, angina, and intermittent claudication).
Positive_regulation (elevated) of Gene_expression (levels) of Lp
4) Confidence 0.47 Published 2001 Journal J Am Geriatr Soc Section Body Doc Link 11207864 Disease Relevance 0.27 Pain Relevance 0
CONCLUSIONS: With the cautions due to the cross-sectional design of the study and the limited statistical power, these results suggest a possible synergistic effect between elevated Lp(a) levels and other pro-atherogenic factors such as smoking on the risk of vascular diseases in older individuals.


Positive_regulation (elevated) of Gene_expression (levels) of Lp
5) Confidence 0.47 Published 2001 Journal J Am Geriatr Soc Section Body Doc Link 11207864 Disease Relevance 0 Pain Relevance 0
In conclusion, Lp(a) was roughly twice as high in acute (unstable angina, myocardial infarction) than in chronic (stable angina) ischemic syndromes, but there was no difference between chronic stable angina and non-IHD.
Positive_regulation (roughly) of Gene_expression (high) of Lp associated with angina, coronary artery disease, syndrome and myocardial infarction
6) Confidence 0.44 Published 1995 Journal Clin Cardiol Section Abstract Doc Link 7489610 Disease Relevance 2.17 Pain Relevance 0.83
The data in the present study indicated that plasma LPA levels were significantly increased in NVAF patients with SBI.
Positive_regulation (increased) of Gene_expression (levels) of LPA in plasma associated with brain hemorrhage and arrhythmias 2 under development
7) Confidence 0.40 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996775 Disease Relevance 1.72 Pain Relevance 0.04
In our study, patients with prominent CVD had elevated serum apoB and Lp(a) levels and apoB/apoA-I ratio values, as well as lower serum levels of apoA-I compared to patients without prevalent CVD.
Positive_regulation (elevated) of Gene_expression (levels) of Lp associated with cardiovascular disease
8) Confidence 0.35 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716782 Disease Relevance 0.82 Pain Relevance 0
Our data clearly implicate Rho-mediated activation of ROCK in mediating LPA and S1P stimulated rounding and aggregation in hES-NEP cells.
Positive_regulation (mediating) of Gene_expression (rounding) of LPA
9) Confidence 0.30 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2621239 Disease Relevance 0 Pain Relevance 0
Similarly, genetic deletion of Autotaxin, the enzyme responsible for production of LPA in the brain, yields embryonically lethal mice with neural tube defects.
Positive_regulation (responsible) of Gene_expression (production) of LPA in neural tube
10) Confidence 0.26 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2621239 Disease Relevance 0.41 Pain Relevance 0
Similarly, LPA stimulated production of inositol phosphates reached a maximal level at 1 ?
Positive_regulation (stimulated) of Gene_expression (production) of LPA
11) Confidence 0.26 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2621239 Disease Relevance 0 Pain Relevance 0
Lin et al showed that LPA stimulated expression of IL-8 and monocyte chemo-attractant protein-1 (MCP-1) in endothelial cells, in a manner that depended on IL-1 [149].
Positive_regulation (stimulated) of Gene_expression (expression) of LPA in endothelial cells
12) Confidence 0.12 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2829540 Disease Relevance 0.38 Pain Relevance 0.15
Thus, the lower levels of Lp(a) in patients with elevated triglyceride could be the result of the rapid catabolism of TRP apo(a) compared with the slower apo(a) catabolism in the LDL density range [17].
Positive_regulation (levels) of Gene_expression (result) of Lp
13) Confidence 0.08 Published 2007 Journal Lipids Health Dis Section Body Doc Link PMC2216007 Disease Relevance 0.78 Pain Relevance 0
Compared to the young normals and healthy elderly subjects, the elderly patients with angina pectoris showed significantly decreased mean serum CETA levels, and significantly increased mean serum levels of Lp(a) and apoprotein B.
Positive_regulation (increased) of Gene_expression (levels) of Lp associated with angina
14) Confidence 0.05 Published 1992 Journal Gerontology Section Abstract Doc Link 1427124 Disease Relevance 0.43 Pain Relevance 0.36
Elevated serum levels of the atherogenic and thrombogenic lipoprotein (a) (Lp(a)) have been recognized as a feature of the nephrotic syndrome associated hyperlipidaemia.
Positive_regulation (Elevated) of Gene_expression (levels) of Lp associated with hyperlipidemia and disorder of lipid metabolism
15) Confidence 0.02 Published 1994 Journal Nephrol. Dial. Transplant. Section Abstract Doc Link 8052429 Disease Relevance 0.44 Pain Relevance 0.17
vitro bicistronic expression of these two genes from AAV plasmid vectors, it was shown that increased synthesis of apoAI and LCAT could play a role in reducing atherosclerotic risk [61].
Positive_regulation (increased) of Gene_expression (synthesis) of apoAI associated with atherosclerosis
16) Confidence 0.01 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC323957 Disease Relevance 1.02 Pain Relevance 0

General Comments

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