INT96480

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Context Info
Confidence 0.30
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.99
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mthfd1) oxidoreductase activity (Mthfd1) ligase activity (Mthfd1)
cytoplasm (Mthfd1)
Anatomy Link Frequency
macrophages 2
DCs 2
cornea 2
T cells 2
Mthfd1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 1 100.00 Very High Very High Very High
antagonist 15 99.98 Very High Very High Very High
mu opioid receptor 7 99.88 Very High Very High Very High
agonist 13 99.74 Very High Very High Very High
Inflammation 76 96.64 Very High Very High Very High
cytokine 8 84.88 Quite High
opioid receptor 1 76.48 Quite High
Opioid 1 72.24 Quite High
ischemia 2 50.00 Quite Low
substance P 11 40.16 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 73 96.64 Very High Very High Very High
Pulmonary Disease 28 81.96 Quite High
Airway Obstruction 1 79.00 Quite High
Nicotine Addiction 9 77.92 Quite High
Infection 44 73.20 Quite High
Severe Acute Respiratory Syndrome 38 50.00 Quite Low
Disease 37 50.00 Quite Low
Metaplasia 22 50.00 Quite Low
Cv Unclassified Under Development 2 50.00 Quite Low
Rigor 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Functionally, treatment of DCs with endomorphin 1 (EM1), a specific agonist of MOR, can inhibit the forskolin-induced formation of cyclic adenosine monophosphate level in activated DCs.
Negative_regulation (inhibit) of Positive_regulation (activated) of DCs in DCs associated with adenocard, mu opioid receptor and agonist
1) Confidence 0.30 Published 2009 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 19189219 Disease Relevance 0 Pain Relevance 0.56
The prolonged presence of AMs in MA15-infected lungs suggested that AMs not only inhibited rDCs activation, and thereby delayed DC migration from lung to lymph nodes, but also inhibited the function of anti-virus T cells in the lung.
Negative_regulation (inhibited) of Positive_regulation (activation) of rDCs in T cells
2) Confidence 0.16 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 0.26 Pain Relevance 0
As limbal cell counts decreased, there was a robust increase in corneal DCs, suggesting centripetal movement of these cells from the limbus into the cornea as inflammation persisted (Figure 5C).
Negative_regulation (decreased) of Positive_regulation (increase) of DCs in cornea associated with inflammation
3) Confidence 0.15 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 0.29 Pain Relevance 0.15
Indeed, daily treatment with the antagonist prevented the significant CS-induced increase in macrophages and DCs that was seen in control animals.
Negative_regulation (prevented) of Positive_regulation (increase) of DCs in macrophages associated with antagonist
4) Confidence 0.14 Published 2009 Journal Respir Res Section Body Doc Link PMC2689186 Disease Relevance 0.44 Pain Relevance 0.13
RESULTS: 1) Calcium chloride, 5 and 14 mmol/L, increased LV systolic pressure by 42% and 70%, respectively (p < 0.001), indicating increased calcium-activated tension, but did not further increase DCS, implying intact diastolic calcium resequestration. 2) Egtazic acid reduced LV systolic pressure by 30% (p < 0.001), indicating reduced intracellular calcium, but failed to reduce increased DCS. 3) Butane-dione-monoxime and NH4Cl chloride affected contractile function (i.e., a calcium-driven force) but did not alter increased DCS. 4) Glucose and insulin, which increase high-energy phosphates during ischemia, reduced increased DCS by 50% (p < 0.001).
Negative_regulation (reduced) of Positive_regulation (increased) of DCS
5) Confidence 0.04 Published 2001 Journal J. Am. Coll. Cardiol. Section Body Doc Link 11419901 Disease Relevance 0 Pain Relevance 0

General Comments

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