INT96481

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Context Info
Confidence 0.02
First Reported 2001
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.30
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mthfd1) oxidoreductase activity (Mthfd1) ligase activity (Mthfd1)
cytoplasm (Mthfd1)
Mthfd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 10 75.12 Quite High
ischemia 3 50.00 Quite Low
cytokine 5 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 205 99.16 Very High Very High Very High
Glioma 23 95.52 Very High Very High Very High
Brain Tumor 47 94.80 High High
Glioblastoma 30 85.52 High High
Immunization 2 83.88 Quite High
INFLAMMATION 9 75.12 Quite High
Injury 1 60.24 Quite High
Cv Unclassified Under Development 2 50.00 Quite Low
Rigor 1 50.00 Quite Low
Coronary Heart Disease 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: 1) Calcium chloride, 5 and 14 mmol/L, increased LV systolic pressure by 42% and 70%, respectively (p < 0.001), indicating increased calcium-activated tension, but did not further increase DCS, implying intact diastolic calcium resequestration. 2) Egtazic acid reduced LV systolic pressure by 30% (p < 0.001), indicating reduced intracellular calcium, but failed to reduce increased DCS. 3) Butane-dione-monoxime and NH4Cl chloride affected contractile function (i.e., a calcium-driven force) but did not alter increased DCS. 4) Glucose and insulin, which increase high-energy phosphates during ischemia, reduced increased DCS by 50% (p < 0.001).
Neg (not) Regulation (alter) of Neg (not) Positive_regulation (increased) of DCS
1) Confidence 0.02 Published 2001 Journal J. Am. Coll. Cardiol. Section Body Doc Link 11419901 Disease Relevance 0 Pain Relevance 0
Furthermore, we show that this treatment is strictly dependent on the activation of TLR signaling on bone-marrow DCs that infiltrate the tumor.
Regulation (dependent) of Positive_regulation (activation) of DCs associated with cancer
2) Confidence 0.01 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 1.30 Pain Relevance 0.04

General Comments

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