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Context Info
Confidence 0.36
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hal) lyase activity (Hal) biosynthetic process (Hal)
cytoplasm (Hal)
Anatomy Link Frequency
cortex 1
Hal (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 8 100.00 Very High Very High Very High
tolerance 7 100.00 Very High Very High Very High
withdrawal 1 100.00 Very High Very High Very High
Nucleus accumbens 1 100.00 Very High Very High Very High
fluoxetine 2 91.68 High High
Eae 1 87.56 High High


Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HAL did not block the development of tolerance to the locomotor stimulant effects of caffeine, but did impair the recovery from tolerance following withdrawal of caffeine. [3H]SCH 23390 (DA D(1)) binding sites were downregulated in the nucleus accumbens and striatum and were upregulated in the prefrontal cortex of caffeine-treated vs. control rats; however, the affinity of [3H]SCH 23390 for these binding sites was unaltered.
Positive_regulation (upregulated) of HAL in cortex associated with nucleus accumbens, dopamine, tolerance and withdrawal
1) Confidence 0.36 Published 2001 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 11420069 Disease Relevance 0 Pain Relevance 0.90

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