INT9649

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 1982
Last Reported 2011
Negated 2
Speculated 5
Reported most in Body
Documents 105
Total Number 111
Disease Relevance 74.75
Pain Relevance 13.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (LPA) transport (LPA) small molecule metabolic process (LPA)
extracellular region (LPA) lipid metabolic process (LPA)
Anatomy Link Frequency
plasma 12
body 3
coronary artery 2
arterioles 1
neural 1
LPA (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 24 99.98 Very High Very High Very High
Fibrositis 467 99.92 Very High Very High Very High
rheumatoid arthritis 112 99.72 Very High Very High Very High
Angina 167 99.64 Very High Very High Very High
Pain 268 99.20 Very High Very High Very High
local anesthetic 7 98.16 Very High Very High Very High
Dismenorea 72 98.08 Very High Very High Very High
metalloproteinase 5 97.96 Very High Very High Very High
depression 142 97.92 Very High Very High Very High
aspirin 85 97.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 676 100.00 Very High Very High Very High
Obesity 199 100.00 Very High Very High Very High
Sleep Disorders 588 99.92 Very High Very High Very High
Atherosclerosis 143 99.92 Very High Very High Very High
Retinal Artery Occlusion 92 99.92 Very High Very High Very High
Cardiovascular Disease 304 99.90 Very High Very High Very High
Birth Weight 75 99.90 Very High Very High Very High
Myocardial Infarction 436 99.88 Very High Very High Very High
Diabetes Mellitus 534 99.84 Very High Very High Very High
Coronary Artery Disease 367 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Left ventricular ejection fraction also decreased linearly with increasing serum Lp(a) levels.
Positive_regulation (increasing) of Lp
1) Confidence 0.69 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978291 Disease Relevance 0.52 Pain Relevance 0
His mother also had an elevated plasma Lp (a) level of 45 mg/dl.
Positive_regulation (elevated) of Lp in plasma
2) Confidence 0.69 Published 2010 Journal Rinsho Shinkeigaku Section Abstract Doc Link 20593666 Disease Relevance 0.42 Pain Relevance 0.08
CONCLUSIONS: Our results indicate that elevated plasma Lp(a) is an independent risk factor for angiographic CAD in chronic stable angina and may have particular significance in women.


Positive_regulation (elevated) of Lp in plasma
3) Confidence 0.59 Published 1998 Journal J. Am. Coll. Cardiol. Section Body Doc Link 9581718 Disease Relevance 0 Pain Relevance 0
Patients with end-stage renal disease (ESRD), who show an enormous prevalence of cardiovascular disease, have elevated plasma concentrations of Lp(a).
Positive_regulation (elevated) of Lp in plasma associated with chronic renal failure, cardiovascular disease and renal disease
4) Confidence 0.56 Published 1997 Journal Clin. Genet. Section Abstract Doc Link 9520130 Disease Relevance 0.78 Pain Relevance 0
In contrast, examining the interactions between elevated Lp(a) and conventional vascular risk factors, when elevated Lp(a) was combined with a history of smoking, a marked increase in the risk of vascular diseases combined (odds ratio [OR]: 4.12; 95% confidence interval [CI]: 1.27-13.40) was observed, much higher than that expected based on the additive effect of smoking and elevated Lp(a) alone.
Positive_regulation (elevated) of Lp
5) Confidence 0.56 Published 2001 Journal J Am Geriatr Soc Section Body Doc Link 11207864 Disease Relevance 0.23 Pain Relevance 0
Some studies have demonstrated association of high serum Lp(a) levels with restenosis after percutaneous coronary angioplasty.20)21) However, it has also been reported that serum Lp(a) levels do not influence restenosis after elective coronary stenting.22)23) Hoffmann et al.24) have demonstrated by serial intravascular ultrasound studies that in-stent restenosis results from neointimal tissue proliferation, which has been attributed to Lp(a) in vitro.25) However, Morita et al.26) studied patients with high Lp(a) levels undergoing POBA as well as PCI and found that there was less difference of TLR rate in the PCI group.
Positive_regulation (levels) of Lp associated with cardiovascular disease
6) Confidence 0.50 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978291 Disease Relevance 0.42 Pain Relevance 0
Lp(a) was measured by an immunonephelometric assay using a latex Lp(a) reagent composed of polystyrene particles coated with a rabbit antihuman Lp(a) ?
Positive_regulation (using) of Lp
7) Confidence 0.50 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978291 Disease Relevance 0.63 Pain Relevance 0
The five-minute increase in the daily duration of LPA was based on findings from our pilot study [12] and was well-tolerated by the majority of participants.
Positive_regulation (increase) of LPA
8) Confidence 0.50 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888205 Disease Relevance 0.30 Pain Relevance 0.09
We thought that his high Lp (a) level was associated with a thrombotic tendency.
Positive_regulation (level) of Lp
9) Confidence 0.50 Published 2010 Journal Rinsho Shinkeigaku Section Abstract Doc Link 20593666 Disease Relevance 0.43 Pain Relevance 0.08
Fluvastatin significantly increased LpA-I (+8%) and apo E (+20%).
Positive_regulation (increased) of LpA
10) Confidence 0.49 Published 1994 Journal Am. J. Med. Section Abstract Doc Link 8017468 Disease Relevance 0.91 Pain Relevance 0.20
Levels of plasma HDL-cholesterol and apoA-I in group I were similar to those in III but were significantly lower than those in II, although the other plasma lipid parameters were not different among the three groups.
Positive_regulation (Levels) of apoA in plasma associated with disorder of lipid metabolism
11) Confidence 0.49 Published 1999 Journal Atherosclerosis Section Abstract Doc Link 9920519 Disease Relevance 1.03 Pain Relevance 0.25
These effects are mediated through a number of G protein-coupled LPA receptors that activate various downstream signaling cascades.
Positive_regulation (mediated) of LPA
12) Confidence 0.49 Published 2002 Journal Neuroreport Section Abstract Doc Link 12488791 Disease Relevance 0.29 Pain Relevance 0.10
RESULTS: No association was observed between elevated Lp(a) levels alone and any of the examined vascular diseases (stroke, myocardial infarction, angina, and intermittent claudication).
Positive_regulation (elevated) of Lp
13) Confidence 0.47 Published 2001 Journal J Am Geriatr Soc Section Body Doc Link 11207864 Disease Relevance 0.27 Pain Relevance 0
In contrast, examining the interactions between elevated Lp(a) and conventional vascular risk factors, when elevated Lp(a) was combined with a history of smoking, a marked increase in the risk of vascular diseases combined (odds ratio [OR]: 4.12; 95% confidence interval [CI]: 1.27-13.40) was observed, much higher than that expected based on the additive effect of smoking and elevated Lp(a) alone.
Positive_regulation (elevated) of Lp
14) Confidence 0.47 Published 2001 Journal J Am Geriatr Soc Section Body Doc Link 11207864 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: With the cautions due to the cross-sectional design of the study and the limited statistical power, these results suggest a possible synergistic effect between elevated Lp(a) levels and other pro-atherogenic factors such as smoking on the risk of vascular diseases in older individuals.


Positive_regulation (elevated) of Lp
15) Confidence 0.47 Published 2001 Journal J Am Geriatr Soc Section Body Doc Link 11207864 Disease Relevance 0 Pain Relevance 0
A number of prospective and retrospective studies have demonstrated that increased levels of Lp(a) are associated with atherosclerosis, ischemic heart disease, and stroke.5)6) In numerous trials, patients with high Lp(a) levels had markedly increased risk of coronary heart disease.7-9) However, the relationship between Lp(a) levels and outcomes after acute myocardial infarction (AMI) is unclear.
Spec (unclear) Positive_regulation (increased) of Lp in heart associated with coronary artery disease, stroke, increased venous pressure under development and myocardial infarction
16) Confidence 0.47 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978291 Disease Relevance 1.01 Pain Relevance 0
The mean age was higher in Tertile 3 than in Tertiles 1 and 2 (64.1±12.0 vs. 61.7±12.5 vs. 62.2±12.6 years, respectively, p=0.059) and there was a trend for females to have increased Lp(a) levels.
Positive_regulation (increased) of Lp
17) Confidence 0.47 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978291 Disease Relevance 0.34 Pain Relevance 0
Kamstrup et al.8) have observed stepwise increases in risk for myocardial infarction with increasing levels of Lp(a) in the general population, but we do not know the severities of the conditions of the patients in their study.
Positive_regulation (increasing) of Lp associated with myocardial infarction
18) Confidence 0.47 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978291 Disease Relevance 0.42 Pain Relevance 0
An elevated Lp(a) concentration on admission and multivessel disease are significant predictors for long-term adverse outcome in AMI patients treated by primary PTCA.
Positive_regulation (elevated) of Lp associated with disease, myocardial infarction and percutaneous transluminal coronary angioplasty
19) Confidence 0.46 Published 2003 Journal Circ. J. Section Abstract Doc Link 12845184 Disease Relevance 0.90 Pain Relevance 0.21
This case-control study was to determine the significance of elevated Lp(a) levels for the existence of CAD by systematically recording cardiovascular risk factors in diagnostic coronary angiography in a group of patients.
Spec (determine) Positive_regulation (elevated) of Lp associated with coronary artery disease
20) Confidence 0.45 Published 2000 Journal J Med Assoc Thai Section Abstract Doc Link 11194014 Disease Relevance 0.84 Pain Relevance 0.30

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox