INT96492

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Context Info
Confidence 0.00
First Reported 2001
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 12.30
Pain Relevance 4.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NGFR) endosome (NGFR) nucleoplasm (NGFR)
cytoplasm (NGFR) signal transducer activity (NGFR) cytosol (NGFR)
Anatomy Link Frequency
nerve 3
synovium 2
sensory neurons 1
tendon cells 1
epithelial cells 1
NGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 89 100.00 Very High Very High Very High
bradykinin 2 99.88 Very High Very High Very High
Inflammatory stimuli 1 99.18 Very High Very High Very High
Central nervous system 6 97.00 Very High Very High Very High
Inflammation 84 96.16 Very High Very High Very High
Pain 21 95.84 Very High Very High Very High
backache 3 93.28 High High
rheumatoid arthritis 65 91.72 High High
palliative 6 90.28 High High
qutenza 35 89.96 High High
Disease Link Frequency Relevance Heat
Stomach Cancer 5 99.82 Very High Very High Very High
Cholangiocarcinoma 74 99.60 Very High Very High Very High
Cancer 141 99.54 Very High Very High Very High
Hereditary Sensory And Autonomic Neuropathies 3 99.42 Very High Very High Very High
Pancreatic Cancer 25 99.06 Very High Very High Very High
INFLAMMATION 75 99.02 Very High Very High Very High
Neurilemmoma 9 98.60 Very High Very High Very High
Aggression 5 98.32 Very High Very High Very High
Malignant Neoplastic Disease 9 98.24 Very High Very High Very High
Apoptosis 33 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to gain insights into the functional consequences of the HSAN V NGF mutation, two sets of hNGFR100 mutants were expressed in Escherichia coli and purified, as mature NGF or proNGF, for in vitro receptor binding studies.
Gene_expression (expressed) of hNGFR100 associated with hereditary sensory and autonomic neuropathies
1) Confidence 0.00 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19945432 Disease Relevance 0.54 Pain Relevance 0.09
Inhibition of p75 NTR expression with siRNA reduced the cell growth inhibiting effects of all the drugs tested.
Gene_expression (expression) of p75 NTR
2) Confidence 0.75 Published 2008 Journal Cancer Chemother. Pharmacol. Section Body Doc Link 17447067 Disease Relevance 0 Pain Relevance 0
All the drugs tested induced an up-regulation in p75 NTR tumor suppressor gene expression in concert with their observed growth inhibiting ability.
Gene_expression (expression) of p75 NTR
3) Confidence 0.75 Published 2008 Journal Cancer Chemother. Pharmacol. Section Body Doc Link 17447067 Disease Relevance 0 Pain Relevance 0
The co-expression of both NGF receptors, p75(NGFR) and tropomyosin-related kinase A (trkA), represents a crucial condition for the antiproliferative effect of NGF; indeed, p75(NGFR) is progressively lost during prostate tumorigenesis and its disappearance represents a malignancy marker of prostate adenocarcinoma (PCa).
Gene_expression (co-expression) of NGFR associated with malignant neoplastic disease, nerve growth factor and prostate cancer
4) Confidence 0.66 Published 2010 Journal Growth Factors Section Abstract Doc Link 20166899 Disease Relevance 0.63 Pain Relevance 0.37
These osteoblasts were shown to produce nerve growth factor and brain-derived neurotrophic factor but not neurotrophin-3, as measured by ELISA. hFOB osteoblasts, cultured at 34 degrees C, secreted significantly (P < 0.01) more brain-derived neurotrophic factor and nerve growth factor into the medium than hFOB cells cultured at 39 degrees C.
Neg (not) Gene_expression (produce) of nerve growth factor in nerve associated with nerve growth factor
5) Confidence 0.45 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11861369 Disease Relevance 0.78 Pain Relevance 0.10
Detection of CD271 as a specific marker for a stromal subpopulation in the synovium and in expanded cells
Gene_expression (Detection) of CD271 in synovium
6) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875643 Disease Relevance 0.16 Pain Relevance 0.08
For Cox univariate analyses in the OS study, high expression of p75NGFR was associated with longer overall survival yet TrkA exhibited opposite effects and included the effect of pain.
Gene_expression (expression) of p75NGFR associated with pain
7) Confidence 0.32 Published 2005 Journal Oncol. Rep. Section Abstract Doc Link 15944784 Disease Relevance 1.16 Pain Relevance 0.46
It appears that in pancreatic cancer cells the growth effects of NGF depend on the expression levels and the ratio of TrkA and p75NGFR.
Gene_expression (expression) of p75NGFR associated with nerve growth factor and pancreatic cancer
8) Confidence 0.32 Published 2005 Journal Oncol. Rep. Section Abstract Doc Link 15944784 Disease Relevance 1.11 Pain Relevance 0.50
Conversely, we also found that elevated p75NGFR expression is associated with a favorable prognosis; we demonstrated that NGF exerts both stimulatory and inhibitory effects on pancreatic cancers with the effect based on the expression levels and the ratio of TrkA and p75NGFR.
Gene_expression (expression) of p75NGFR associated with nerve growth factor and pancreatic cancer
9) Confidence 0.32 Published 2005 Journal Oncol. Rep. Section Abstract Doc Link 15944784 Disease Relevance 1.02 Pain Relevance 0.38
A certain expression of CD271 was maintained but cells positive for both CD271 and CD34 were not longer detected (Table 5).


Gene_expression (expression) of CD271
10) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875643 Disease Relevance 0.06 Pain Relevance 0.03
CD271 was expressed in most of the samples (Figure 7b), with a median value of 4.7% of the stromal compartment, and 3.1% of the stromal cells were both CD271 and CD34 positive.
Gene_expression (expressed) of CD271 in stromal cells
11) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875643 Disease Relevance 0.07 Pain Relevance 0.04
CD271 has been associated with bone marrow-derived mesenchymal progenitor cells but does not appear to be present on expanded mesenchymal progenitor cells from the synovium [14,16,17,25].
Gene_expression (present) of CD271 in synovium
12) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875643 Disease Relevance 0.15 Pain Relevance 0.07
We have now detected, by immunohistochemistry, beta3-subunits in 82% of small/medium and 67% of large diameter sensory neurons in intact human dorsal root ganglia: 54% of beta3 small/medium neurons were NGF receptor trkA negative.
Neg (negative) Gene_expression (negative) of NGF receptor in sensory neurons
13) Confidence 0.29 Published 2004 Journal Neuroreport Section Abstract Doc Link 15232296 Disease Relevance 0.27 Pain Relevance 0.46
However, trk receptors as well as p75NTR are also expressed on non-neuronal cells, including immune cells, muscle cells and epithelial cells.
Gene_expression (expressed) of p75NTR in epithelial cells
14) Confidence 0.26 Published 2001 Journal Respir Res Section Body Doc Link PMC59513 Disease Relevance 0.19 Pain Relevance 0.29
In contrast, expression of CD95 (Figure 4D), TNFR1 or NGFR (data not shown) did not promote Trx1 interactions with the cell surface, further strengthening the notion that Trx1 reactivity is a specific property of CD30.
Gene_expression (expression) of NGFR
15) Confidence 0.25 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.05 Pain Relevance 0
About 20 % of gastric cancers exhibit overexpression of the growth factor receptor family member Her2.
Gene_expression (overexpression) of growth factor receptor associated with stomach cancer
16) Confidence 0.22 Published 2010 Journal Dtsch. Med. Wochenschr. Section Abstract Doc Link 20721843 Disease Relevance 0.65 Pain Relevance 0.09
The cells stained poorly for LNGFR and STRO1, which are markers on freshly isolated bone marrow-derived stem cells, and stained sparsely for 3G5, the marker for vascular pericytes.
Gene_expression (stained) of LNGFR in stem cells
17) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575620 Disease Relevance 0.39 Pain Relevance 0
Unexpected presence of the neurotrophins NGF and BDNF and the neurotrophin receptor p75 in the tendon cells of the human Achilles tendon.
Gene_expression (presence) of neurotrophin receptor in tendon cells
18) Confidence 0.13 Published 2009 Journal Histol. Histopathol. Section Title Doc Link 19475530 Disease Relevance 0.46 Pain Relevance 0.17
All tumors studied were strongly positive for S-100 protein and also for low affinity nerve growth factor receptor (p75), collagen IV, and GFAP.
Gene_expression (positive) of nerve growth factor receptor in nerve associated with nerve growth factor and cancer
19) Confidence 0.11 Published 2001 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 11420455 Disease Relevance 1.28 Pain Relevance 0.12
However, trk receptors as well as p75NTR are also expressed on non-neuronal cells, including immune cells, muscle cells and epithelial cells.
Gene_expression (expressed) of p75NTR in muscle cells
20) Confidence 0.09 Published 2001 Journal Respir Res Section Body Doc Link PMC59513 Disease Relevance 0.19 Pain Relevance 0.29

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