INT96504
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Once inside the nerve terminals, methamphetamine causes the releases of dopamine and norepinephrine from vesicles by blocking the vesicular monoamine transporter (VMAT2). | |||||||||||||||
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In PD patients, SPECT and PET studies have shown a progressive loss of DAT and VMAT2 and reduced dopa decarboxylase activity using [18F]-fluoro-dopa PET (Table 2). | |||||||||||||||
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Once inside the nerve terminals, methamphetamine causes the releases of dopamine and norepinephrine from vesicles by blocking the vesicular monoamine transporter (VMAT2). | |||||||||||||||
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The LC neurones also stored the vesicular monoamine transporter (VMAT)- and the C-terminal flanking peptide of neuropeptide Y (C-PON)-ir, illustrating their adrenergic nature. | |||||||||||||||
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VMAT2 is inhibited by some drugs such as reserpine and tetrabenazine, leading to the initial release of the monoamine followed by depletion of the stores, resulting in reduction/cessation of release [107]. | |||||||||||||||
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Antidepressants suppress production of the Th1 cytokine interferon-gamma, independent of monoamine transporter blockade. | |||||||||||||||
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General Comments
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