INT96504

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Context Info
Confidence 0.36
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.07
Pain Relevance 4.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (SLC18A2) plasma membrane (SLC18A2) enzyme binding (SLC18A2)
transmembrane transport (SLC18A2) cytoplasm (SLC18A2)
Anatomy Link Frequency
nerve 2
SLC18A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
monoamine 32 100.00 Very High Very High Very High
Locus ceruleus 354 99.70 Very High Very High Very High
positron emission tomography 46 99.32 Very High Very High Very High
antidepressant 13 99.32 Very High Very High Very High
cytokine 8 99.32 Very High Very High Very High
Dopamine 113 99.26 Very High Very High Very High
Neuropeptide 3 98.08 Very High Very High Very High
noradrenaline 60 97.68 Very High Very High Very High
Serotonin 5 97.64 Very High Very High Very High
Desipramine 3 96.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 74 98.84 Very High Very High Very High
Parkinsonian Disorders 39 97.00 Very High Very High Very High
INFLAMMATION 4 90.72 High High
Liver Disease 12 84.56 Quite High
Salivary Gland Disease 4 79.80 Quite High
Headache 2 76.80 Quite High
Urological Neuroanatomy 19 76.56 Quite High
Toxicity 9 71.32 Quite High
Newborn Drug Withdrawal Syndrome 26 66.56 Quite High
Drug Induced Neurotoxicity 9 62.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Once inside the nerve terminals, methamphetamine causes the releases of dopamine and norepinephrine from vesicles by blocking the vesicular monoamine transporter (VMAT2).
Negative_regulation (blocking) of monoamine transporter in nerve associated with dopamine and monoamine
1) Confidence 0.36 Published 2010 Journal Neuropsychol Rev Section Body Doc Link PMC2988996 Disease Relevance 0.20 Pain Relevance 0.70
In PD patients, SPECT and PET studies have shown a progressive loss of DAT and VMAT2 and reduced dopa decarboxylase activity using [18F]-fluoro-dopa PET (Table 2).
Negative_regulation (loss) of VMAT2 associated with positron emission tomography and disease
2) Confidence 0.34 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.73 Pain Relevance 0.51
Once inside the nerve terminals, methamphetamine causes the releases of dopamine and norepinephrine from vesicles by blocking the vesicular monoamine transporter (VMAT2).
Negative_regulation (blocking) of VMAT2 in nerve associated with dopamine and monoamine
3) Confidence 0.26 Published 2010 Journal Neuropsychol Rev Section Body Doc Link PMC2988996 Disease Relevance 0.20 Pain Relevance 0.71
The LC neurones also stored the vesicular monoamine transporter (VMAT)- and the C-terminal flanking peptide of neuropeptide Y (C-PON)-ir, illustrating their adrenergic nature.
Negative_regulation (stored) of vesicular monoamine transporter associated with locus ceruleus, neuropeptide and monoamine
4) Confidence 0.26 Published 2001 Journal Cephalalgia Section Abstract Doc Link 11422090 Disease Relevance 0.45 Pain Relevance 1.17
VMAT2 is inhibited by some drugs such as reserpine and tetrabenazine, leading to the initial release of the monoamine followed by depletion of the stores, resulting in reduction/cessation of release [107].
Negative_regulation (inhibited) of VMAT2 associated with monoamine
5) Confidence 0.19 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687931 Disease Relevance 0.25 Pain Relevance 0.54
Antidepressants suppress production of the Th1 cytokine interferon-gamma, independent of monoamine transporter blockade.
Negative_regulation (blockade) of monoamine transporter associated with antidepressant, monoamine and cytokine
6) Confidence 0.11 Published 2006 Journal Eur Neuropsychopharmacol Section Title Doc Link 16388933 Disease Relevance 0.25 Pain Relevance 0.99

General Comments

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