INT96504

Context Info Confidence 0.36 First Reported 2001 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 6 Disease Relevance 2.07 Pain Relevance 4.62

aging (SLC18A2) plasma membrane (SLC18A2) enzyme binding (SLC18A2) transmembrane transport (SLC18A2) cytoplasm (SLC18A2)

Anatomy Link Frequency nerve 2 SLC18A2 (Homo sapiens)

Pain Link Frequency Relevance Heat monoamine 32 100.00 Locus ceruleus 354 99.70 positron emission tomography 46 99.32 antidepressant 13 99.32 cytokine 8 99.32 Dopamine 113 99.26 Neuropeptide 3 98.08 noradrenaline 60 97.68 Serotonin 5 97.64 Desipramine 3 96.00

Disease Link Frequency Relevance Heat Disease 74 98.84 Parkinsonian Disorders 39 97.00 INFLAMMATION 4 90.72 Liver Disease 12 84.56 Salivary Gland Disease 4 79.80 Headache 2 76.80 Urological Neuroanatomy 19 76.56 Toxicity 9 71.32 Newborn Drug Withdrawal Syndrome 26 66.56 Drug Induced Neurotoxicity 9 62.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Once inside the nerve terminals, methamphetamine causes the releases of dopamine and norepinephrine from vesicles by blocking the vesicular monoamine transporter (VMAT2).

Negative_regulation (blocking) of monoamine transporter in nerve associated with dopamine and monoamine

1) Confidence 0.36 Published 2010 Journal Neuropsychol Rev Section Body Doc Link PMC2988996 Disease Relevance 0.20 Pain Relevance 0.70

In PD patients, SPECT and PET studies have shown a progressive loss of DAT and VMAT2 and reduced dopa decarboxylase activity using [18F]-fluoro-dopa PET (Table 2).

Negative_regulation (loss) of VMAT2 associated with positron emission tomography and disease

2) Confidence 0.34 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.73 Pain Relevance 0.51

Once inside the nerve terminals, methamphetamine causes the releases of dopamine and norepinephrine from vesicles by blocking the vesicular monoamine transporter (VMAT2).

Negative_regulation (blocking) of VMAT2 in nerve associated with dopamine and monoamine

3) Confidence 0.26 Published 2010 Journal Neuropsychol Rev Section Body Doc Link PMC2988996 Disease Relevance 0.20 Pain Relevance 0.71

The LC neurones also stored the vesicular monoamine transporter (VMAT)- and the C-terminal flanking peptide of neuropeptide Y (C-PON)-ir, illustrating their adrenergic nature.

Negative_regulation (stored) of vesicular monoamine transporter associated with locus ceruleus, neuropeptide and monoamine

4) Confidence 0.26 Published 2001 Journal Cephalalgia Section Abstract Doc Link 11422090 Disease Relevance 0.45 Pain Relevance 1.17

VMAT2 is inhibited by some drugs such as reserpine and tetrabenazine, leading to the initial release of the monoamine followed by depletion of the stores, resulting in reduction/cessation of release [107].

Negative_regulation (inhibited) of VMAT2 associated with monoamine

5) Confidence 0.19 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687931 Disease Relevance 0.25 Pain Relevance 0.54

Antidepressants suppress production of the Th1 cytokine interferon-gamma, independent of monoamine transporter blockade.

Negative_regulation (blockade) of monoamine transporter associated with antidepressant, monoamine and cytokine

6) Confidence 0.11 Published 2006 Journal Eur Neuropsychopharmacol Section Title Doc Link 16388933 Disease Relevance 0.25 Pain Relevance 0.99

General Comments

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