INT96510

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.31
Pain Relevance 5.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr1b) cytoplasm (Htr1b) signal transducer activity (Htr1b)
Anatomy Link Frequency
neurons 2
neuronal 1
hypothalamus 1
trigeminal ganglion 1
blood vessel smooth muscles 1
Htr1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nociceptor 6 100.00 Very High Very High Very High
Serotonin 11 99.98 Very High Very High Very High
Neuronal excitability 2 99.78 Very High Very High Very High
fluoxetine 13 99.68 Very High Very High Very High
substance P 16 99.28 Very High Very High Very High
Sumatriptan 43 99.16 Very High Very High Very High
Triptan 13 99.16 Very High Very High Very High
Migraine 15 99.00 Very High Very High Very High
Trigeminal ganglion neurons 8 98.68 Very High Very High Very High
Opioid 10 94.80 High High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 6 99.70 Very High Very High Very High
Headache 16 99.00 Very High Very High Very High
Ganglion Cysts 8 98.24 Very High Very High Very High
Urological Neuroanatomy 57 98.12 Very High Very High Very High
Cluster Headache 4 78.40 Quite High
Pain 9 55.28 Quite High
Nociception 2 35.28 Quite Low
INFLAMMATION 1 20.00 Low Low
Neuropathic Pain 1 15.28 Low Low
Depression 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken all together, these results suggest that serotonin 5-HT1B receptors significantly contribute to the control of spiking of the rat GP neurons, and that the 5-HT1B receptors exerting this control are most likely localized in the striato-pallidal pathway.
Localization (localized) of 5-HT1B in neurons associated with serotonin
1) Confidence 0.78 Published 2005 Journal Brain Res. Section Abstract Doc Link 15862532 Disease Relevance 0 Pain Relevance 0.27
The combination of fluoxetine and T3 induced desensitization of 5-HT1B autoreceptors in hypothalamus.
Localization (desensitization) of 5-HT1B in hypothalamus associated with fluoxetine
2) Confidence 0.73 Published 2004 Journal J. Neurosci. Methods Section Abstract Doc Link 15589343 Disease Relevance 0.19 Pain Relevance 0.63
Taken all together, these results suggest that serotonin 5-HT1B receptors significantly contribute to the control of spiking of the rat GP neurons, and that the 5-HT1B receptors exerting this control are most likely localized in the striato-pallidal pathway.
Localization (localized) of 5-HT1B in neurons associated with serotonin
3) Confidence 0.73 Published 2005 Journal Brain Res. Section Abstract Doc Link 15862532 Disease Relevance 0 Pain Relevance 0.29
It is also possible that 5-HT and sumatriptan modulate neuronal excitability by direct 5-HT1B, D and F receptor mediated postsynaptic actions, as previously demonstrated for ?
Localization (receptor) of 5-HT1B in neuronal associated with sumatriptan and neuronal excitability
4) Confidence 0.73 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.61 Pain Relevance 1.81
Anti-migraine triptan drugs block vasodilatation by binding to 5-HT1B/1D receptors localized on the peripheral sensory terminals and dural blood vessel smooth muscles.
Localization (localized) of 5-HT1B in blood vessel smooth muscles associated with migraine, triptan and increased venous pressure under development
5) Confidence 0.14 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11422450 Disease Relevance 0.73 Pain Relevance 0.98
Colocalization of CGRP with 5-HT1B/1D receptors and substance P in trigeminal ganglion neurons in rats.
Localization (Colocalization) of 5-HT1B in trigeminal ganglion associated with ganglion cysts, nociceptor, trigeminal ganglion neurons and substance p
6) Confidence 0.13 Published 2001 Journal Eur. J. Neurosci. Section Title Doc Link 11422450 Disease Relevance 0.77 Pain Relevance 1.52

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