INT96514

Context Info Confidence 0.03 First Reported 2001 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 5.40 Pain Relevance 6.05

cytosol (Trpv1) plasma membrane (Trpv1) molecular_function (drg) cellular_component (drg) lipid metabolic process (Trpv1)

Anatomy Mention Frequency neurons 3 DRG 2 nerve 1 Trpv1 (Rattus norvegicus) drg (Drosophila melanogaster)

Pain Term Frequency Confidence Heat Spinal nerve ligature 5 100.00 dorsal root ganglion 125 100.00 Nerve growth factor 17 100.00 Pain 69 100.00 agonist 9 100.00 Acute pain 1 99.28 Stimulus evoked pain 4 99.16 Neuropathic pain 32 98.40 Inflammation 54 98.24 c fibre 3 96.96

Disease Term Frequency Confidence Heat Pain 74 100.00 Ganglion Cysts 128 100.00 Hypersensitivity 11 99.16 Neuropathic Pain 73 98.40 INFLAMMATION 47 98.24 Targeted Disruption 1 96.00 Injury 17 93.28 Hyperalgesia 17 90.56 Nervous System Injury 50 79.20 Nociception 20 63.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We concluded that PKD1 in DRG, through interaction with TRPV1, is involved in developing and maintaining inflammatory heat hypersensitivity.

TRPV1 Binding (interaction) of DRG in DRG associated with inflammation and hypersensitivity

1) Confidence 0.03 Published 2008 Journal Pain Section Abstract Doc Link 18063480 Disease Relevance 0.61 Pain Relevance 0.25

ERK activation in DRG neurons may also contribute to altered heat sensitivity by interacting with the transient receptor potential vanilloid receptor-1 (TRPV1), as demonstrated by Zhuang et al. (2004) [118].

vanilloid receptor-1 Binding (interacting) of DRG in neurons

2) Confidence 0.02 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.63 Pain Relevance 0.68

Unexpectedly, after L5 spinal nerve ligation, VR1-IR of the A-fibre somata increased approximately 3-fold in the uninjured L4 DRG compared to controls; a much greater increase than seen in the somata with C-fibres.

VR1 Binding (ligation) of DRG in DRG associated with c fibre, dorsal root ganglion and spinal nerve ligature

3) Confidence 0.02 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11422451 Disease Relevance 0.98 Pain Relevance 1.04

ERK activation in DRG neurons may also contribute to altered heat sensitivity by interacting with the transient receptor potential vanilloid receptor-1 (TRPV1), as demonstrated by Zhuang et al. (2004) [118].

TRPV1 Binding (interacting) of DRG in neurons

4) Confidence 0.01 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.63 Pain Relevance 0.68

Our recent study provided new evidence for the expression of NK-1 receptor protein and interaction with TRPV1, a crucial pain signal molecule, in DRG neurons [9].

TRPV1 Binding (interaction) of DRG in neurons associated with dorsal root ganglion and pain

5) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2715383 Disease Relevance 0.69 Pain Relevance 1.64

By contrast, in DRG neurons, the phosphorylation of CaMKII has an important role in nerve growth factor-induced sensitization of TRPV1 [25] and modulation of the agonist binding to TRPV1 [26].

TRPV1 Binding (binding) of DRG in nerve associated with dorsal root ganglion, nerve growth factor and agonist

6) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.86 Pain Relevance 1.77

General Comments

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