INT96514

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Context Info
Confidence 0.03
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.40
Pain Relevance 6.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) plasma membrane (Trpv1) molecular_function (drg)
cellular_component (drg) lipid metabolic process (Trpv1)
Anatomy Mention Frequency
neurons 3
DRG 2
nerve 1
Trpv1 (Rattus norvegicus)
drg (Drosophila melanogaster)
Pain Term Frequency Confidence Heat
Spinal nerve ligature 5 100.00 Very High Very High Very High
dorsal root ganglion 125 100.00 Very High Very High Very High
Nerve growth factor 17 100.00 Very High Very High Very High
Pain 69 100.00 Very High Very High Very High
agonist 9 100.00 Very High Very High Very High
Acute pain 1 99.28 Very High Very High Very High
Stimulus evoked pain 4 99.16 Very High Very High Very High
Neuropathic pain 32 98.40 Very High Very High Very High
Inflammation 54 98.24 Very High Very High Very High
c fibre 3 96.96 Very High Very High Very High
Disease Term Frequency Confidence Heat
Pain 74 100.00 Very High Very High Very High
Ganglion Cysts 128 100.00 Very High Very High Very High
Hypersensitivity 11 99.16 Very High Very High Very High
Neuropathic Pain 73 98.40 Very High Very High Very High
INFLAMMATION 47 98.24 Very High Very High Very High
Targeted Disruption 1 96.00 Very High Very High Very High
Injury 17 93.28 High High
Hyperalgesia 17 90.56 High High
Nervous System Injury 50 79.20 Quite High
Nociception 20 63.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We concluded that PKD1 in DRG, through interaction with TRPV1, is involved in developing and maintaining inflammatory heat hypersensitivity.
TRPV1 Binding (interaction) of DRG in DRG associated with inflammation and hypersensitivity
1) Confidence 0.03 Published 2008 Journal Pain Section Abstract Doc Link 18063480 Disease Relevance 0.61 Pain Relevance 0.25
ERK activation in DRG neurons may also contribute to altered heat sensitivity by interacting with the transient receptor potential vanilloid receptor-1 (TRPV1), as demonstrated by Zhuang et al. (2004) [118].
vanilloid receptor-1 Binding (interacting) of DRG in neurons
2) Confidence 0.02 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.63 Pain Relevance 0.68
Unexpectedly, after L5 spinal nerve ligation, VR1-IR of the A-fibre somata increased approximately 3-fold in the uninjured L4 DRG compared to controls; a much greater increase than seen in the somata with C-fibres.
VR1 Binding (ligation) of DRG in DRG associated with c fibre, dorsal root ganglion and spinal nerve ligature
3) Confidence 0.02 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11422451 Disease Relevance 0.98 Pain Relevance 1.04
ERK activation in DRG neurons may also contribute to altered heat sensitivity by interacting with the transient receptor potential vanilloid receptor-1 (TRPV1), as demonstrated by Zhuang et al. (2004) [118].
TRPV1 Binding (interacting) of DRG in neurons
4) Confidence 0.01 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.63 Pain Relevance 0.68
Our recent study provided new evidence for the expression of NK-1 receptor protein and interaction with TRPV1, a crucial pain signal molecule, in DRG neurons [9].
TRPV1 Binding (interaction) of DRG in neurons associated with dorsal root ganglion and pain
5) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2715383 Disease Relevance 0.69 Pain Relevance 1.64
By contrast, in DRG neurons, the phosphorylation of CaMKII has an important role in nerve growth factor-induced sensitization of TRPV1 [25] and modulation of the agonist binding to TRPV1 [26].
TRPV1 Binding (binding) of DRG in nerve associated with dorsal root ganglion, nerve growth factor and agonist
6) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.86 Pain Relevance 1.77

General Comments

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