INT96517

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Context Info
Confidence 0.08
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 22
Disease Relevance 4.16
Pain Relevance 4.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gfra3) plasma membrane (Gfra3) cytoplasm (Gfra3)
Anatomy Link Frequency
sensory neurons 3
neurons 2
sympathetic 2
dorsal root ganglia 2
IB4 1
Gfra3 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 320 100.00 Very High Very High Very High
Pain 15 100.00 Very High Very High Very High
dorsal root ganglion 10 99.76 Very High Very High Very High
Nerve growth factor 464 99.48 Very High Very High Very High
Peripheral nervous system 17 98.72 Very High Very High Very High
Calcitonin gene-related peptide 357 98.16 Very High Very High Very High
trigeminal ganglion 16 89.68 High High
TRP channel 112 85.76 High High
Nav1.9 16 78.12 Quite High
sodium channel 48 77.84 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1066 99.86 Very High Very High Very High
Nociception 22 99.28 Very High Very High Very High
Targeted Disruption 225 98.76 Very High Very High Very High
Death 112 64.40 Quite High
INFLAMMATION 32 28.08 Quite Low
Apoptosis 128 20.52 Low Low
Sprains And Strains 96 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 96 5.00 Very Low Very Low Very Low
Pain 21 5.00 Very Low Very Low Very Low
Hyperalgesia 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of the GFRalpha3 receptor is primarily restricted to the peripheral nervous system and is found in a subpopulation of nociceptive sensory neurons of the dorsal root ganglia (DRGs) that coexpress the Ret and TrkA receptor tyrosine kinases and the thermosensitive channel TRPV1.
Gene_expression (Expression) of GFRalpha3 receptor in dorsal root ganglia associated with nociception and peripheral nervous system
1) Confidence 0.08 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16914684 Disease Relevance 0.17 Pain Relevance 0.05
Using immunohistochemical methods, we show that the majority of dorsal root ganglion cells that express GFRalpha3 also express vanilloid receptor type 1, peripherin, RET, trkA and calcitonin gene-related peptide.
Gene_expression (express) of GFRalpha3 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion and calcitonin gene-related peptide
2) Confidence 0.05 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11422460 Disease Relevance 0.27 Pain Relevance 0.29
GFRalpha3 is expressed predominantly in nociceptive sensory neurons.
Gene_expression (expressed) of GFRalpha3 in sensory neurons associated with nociception and nociceptor
3) Confidence 0.05 Published 2001 Journal Eur. J. Neurosci. Section Title Doc Link 11422460 Disease Relevance 0.26 Pain Relevance 0.64
The major site of GFRalpha3 expression is in the dorsal root ganglion; however, the class of sensory neurons that expresses GFRalpha3 has not been reported previously.
Gene_expression (expresses) of GFRalpha3 in sensory neurons associated with ganglion cysts and dorsal root ganglion
4) Confidence 0.05 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11422460 Disease Relevance 0.27 Pain Relevance 0.26
The major site of GFRalpha3 expression is in the dorsal root ganglion; however, the class of sensory neurons that expresses GFRalpha3 has not been reported previously.
Gene_expression (expression) of GFRalpha3 in sensory neurons associated with ganglion cysts and dorsal root ganglion
5) Confidence 0.05 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11422460 Disease Relevance 0.26 Pain Relevance 0.19
In addition, a significant subpopulation of GFRalpha3-expressing cells also binds the lectin IB4.
Gene_expression (expressing) of GFRalpha3-expressing in IB4
6) Confidence 0.04 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11422460 Disease Relevance 0.25 Pain Relevance 0.31
The expression of mRNAs for GFRalpha1, GFRalpha2, GFRalpha3 and ret is dynamically regulated in mouse sympathetic ganglia during embryogenesis (Nishino et al. 1999; Enomoto et al. 2001).
Gene_expression (expression) of GFRalpha3 in sympathetic
7) Confidence 0.02 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.46 Pain Relevance 0.04
Signals regulating GFRalpha3 expression remain to be determined.
Gene_expression (expression) of GFRalpha3
8) Confidence 0.02 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.16
In addition, ret mutation leads to a reduction of GFRalpha1 and GFRalpha2, but not GFRalpha3, expression.
Gene_expression (expression) of GFRalpha3
9) Confidence 0.02 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.44
Some 34% of ret-positive cells express GFRalpha2 and 33% express GFRalpha3 in the lumbar DRG of adult rat (Kashiba et al. 2003).
Gene_expression (express) of GFRalpha3
10) Confidence 0.02 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.46
Strong GFRalpha3 expression is detectable in a population of DRG neurons.
Gene_expression (expression) of GFRalpha3 in neurons
11) Confidence 0.02 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.34 Pain Relevance 0
The percentage of TRPV1-positive cells is no different in transgenic animals (29% compared with 28% in wildtype) and overlap with GFRalpha3 expression is nearly complete.
Gene_expression (expression) of GFRalpha3 associated with targeted disruption
12) Confidence 0.02 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.48 Pain Relevance 0.15
At P5, 20%–30% of SCG cells express GFRalpha3.
Gene_expression (express) of GFRalpha3 associated with ganglion cysts
13) Confidence 0.02 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.26 Pain Relevance 0
In adult mice, 82% of GFRalpha3-positive cells express ret, as analysed by double IHC (Orozco et al. 2001).
Gene_expression (express) of GFRalpha3-positive
14) Confidence 0.02 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.22
There is a large but incomplete overlap of ret and GFRalpha expression ret expression overlaps largely with expression of GFRalpha1, GFRalpha2 and GFRalpha3.
Gene_expression (expression) of GFRalpha3
15) Confidence 0.02 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.58
Another third of ret-positive cells expresses GFRalpha3.
Gene_expression (expresses) of GFRalpha3
16) Confidence 0.02 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.15 Pain Relevance 0.39
GFRalpha3 mRNA is expressed at low levels at E13 in most neurons and at high levels at E16 in the majority of neurons.
Gene_expression (expressed) of GFRalpha3 mRNA in neurons
17) Confidence 0.02 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.03
In P14 mice, 61% and 14% of ret-positive cells express GFRalpha2 and GFRalpha3, respectively (Luo et al. 2007).
Gene_expression (express) of GFRalpha3
18) Confidence 0.02 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.41
Data on the coexpression of GFRalpha receptors differ between studies (Bennett et al. 1998; Kashiba et al. 2003).Expression of GFRalpha1 and GFRalpha2, but not GFRalpha3, depends on NGF, as shown in newborn NGF/Bax double-mutant mice where GFRalpha1 is undetectable and GFRalpha2 expression is strongly reduced (Luo et al. 2007).
Gene_expression (.Expression) of GFRalpha3 associated with nerve growth factor
19) Confidence 0.02 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.17
Fig. 3Expression of mRNAs for GFRalpha2 and GFRalpha3 in sympathetic ganglia and DRG of a newborn mouse.
Gene_expression (3Expression) of GFRalpha3 in sympathetic
20) Confidence 0.02 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.33 Pain Relevance 0

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