INT96532

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Context Info
Confidence 0.59
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 14.22
Pain Relevance 17.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc1a2)
Anatomy Link Frequency
spinal 10
spinal cord 8
neuronal 4
striatum 3
thalamus 3
Slc1a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 617 100.00 Very High Very High Very High
Spinal cord 265 100.00 Very High Very High Very High
spinal dorsal horn 81 100.00 Very High Very High Very High
antagonist 33 100.00 Very High Very High Very High
Inflammation 191 99.96 Very High Very High Very High
Sciatic nerve 73 99.80 Very High Very High Very High
allodynia 47 99.80 Very High Very High Very High
Hyperalgesia 152 99.36 Very High Very High Very High
Neuropathic pain 148 99.28 Very High Very High Very High
Thalamus 37 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 197 99.96 Very High Very High Very High
Targeted Disruption 2 99.84 Very High Very High Very High
Neuropathic Pain 255 99.80 Very High Very High Very High
Disease 26 99.40 Very High Very High Very High
Urological Neuroanatomy 1 99.38 Very High Very High Very High
Hyperalgesia 160 99.36 Very High Very High Very High
Nervous System Injury 122 99.32 Very High Very High Very High
Neurodegenerative Disease 12 98.28 Very High Very High Very High
Nociception 146 98.00 Very High Very High Very High
Schizophrenia 5 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of GLT-1 mRNA was significantly decreased in the striatum and thalamus of morphine-dependent rats, and significantly increased in the striatum 2 h after the naloxone-precipitated withdrawal, compared with that of naive rats.
Negative_regulation (decreased) of Gene_expression (expression) of GLT-1 mRNA in thalamus associated with narcan, thalamus, withdrawal and morphine
1) Confidence 0.59 Published 2001 Journal Brain Res. Section Abstract Doc Link 11423104 Disease Relevance 0.17 Pain Relevance 0.97
Similar results were obtained with a transient reduction of GLT-1 protein expression by antisense oligonucleotides.
Negative_regulation (reduction) of Gene_expression (expression) of GLT-1 protein
2) Confidence 0.59 Published 2003 Journal Neuroscience Section Abstract Doc Link 12535941 Disease Relevance 0.57 Pain Relevance 0.35
Furthermore, it recovered the extent of the spinal GLT-1 expression in the membrane fraction that was decreased at 7 days following pSNL.
Negative_regulation (recovered) of Gene_expression (expression) of GLT-1 in spinal
3) Confidence 0.57 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628654 Disease Relevance 1.20 Pain Relevance 1.09
Many previous studies have shown that the expression of GLT-1 and glutamate uptake activity are decreased 7–14 days after nerve injury [5,19,20,22].
Negative_regulation (decreased) of Gene_expression (expression) of GLT-1 in nerve associated with glutamate and nervous system injury
4) Confidence 0.57 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628654 Disease Relevance 0.74 Pain Relevance 1.09
Similarly, we found a decrease in GLT-1 expression in the membrane fraction of the spinal cord at 7 days following pSNL, although the total amount of GLT-1 protein was not changed in the present pSNL-induced neuropathic pain model in contrast to previous reports using other neuropathic pain models [19,22].
Negative_regulation (decrease) of Gene_expression (expression) of GLT-1 in spinal cord associated with eae, neuropathic pain and spinal cord
5) Confidence 0.57 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628654 Disease Relevance 0.82 Pain Relevance 1.06
These data suggest that inhibition of GLT-1 activity or expression reduces excitatory synaptic efficacy and thereby nociception.
Negative_regulation (inhibition) of Gene_expression (expression) of GLT-1 associated with nociception
6) Confidence 0.43 Published 2003 Journal Neuroscience Section Abstract Doc Link 12535941 Disease Relevance 0.56 Pain Relevance 0.34
By northern blot analysis, the expression of GLT-1 mRNA was found to decrease significantly in the striatum and thalamus of morphine-dependent rats, and to increase significantly in the striatum 2 hr after the naloxone-precipitated withdrawal.
Negative_regulation (decrease) of Gene_expression (expression) of GLT-1 mRNA in striatum associated with narcan, thalamus, withdrawal and morphine
7) Confidence 0.43 Published 2001 Journal Yakugaku Zasshi Section Abstract Doc Link 11558151 Disease Relevance 0.16 Pain Relevance 1.32
Spinal GLT-1 gene transfer 7 days before partial sciatic nerve ligation recovered the extent of the spinal GLT-1 expression in the membrane fraction that was decreased following the nerve ligation, and prevented the induction of tactile allodynia.
Negative_regulation (recovered) of Gene_expression (expression) of GLT-1 in Spinal associated with brush evoked pain and sciatic nerve
8) Confidence 0.42 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2628654 Disease Relevance 1.10 Pain Relevance 1.25
Furthermore, it recovered the extent of the spinal GLT-1 expression in the membrane fraction that was decreased at 7 days following pSNL.
Negative_regulation (decreased) of Gene_expression (expression) of GLT-1 in spinal
9) Confidence 0.42 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628654 Disease Relevance 1.16 Pain Relevance 1.10
Immunohistochemical studies show that the expression of both GLAST and GLT-1 in the L4-L5 spinal dorsal horn is decreased by 24% (P<0.001) and 23% (P<0.001), respectively, in rats with taxol-induced hyperalgesia as compared with those in control rats.
Negative_regulation (decreased) of Gene_expression (expression) of GLT-1 in spinal associated with hyperalgesia, spinal dorsal horn and taxol
10) Confidence 0.42 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15975716 Disease Relevance 0.33 Pain Relevance 0.88
The present study showed that contralateral allodynia was also prevented by the unilateral gene transfer of GLT-1 into the ipsilateral spinal cord, although the unilateral gene transfer did not spread to the contralateral spinal cord.
Negative_regulation (prevented) of Gene_expression (transfer) of GLT-1 in spinal cord associated with allodynia and spinal cord
11) Confidence 0.41 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628654 Disease Relevance 1.29 Pain Relevance 1.51
The expression of GLT-1 was significantly decreased in the ipsilateral spinal dorsal horn at 7(p < 0.01) and 14 days (p < 0.01) after PSNL (Figure 2C, 2D) compared with controls (Figure 2A).
Negative_regulation (decreased) of Gene_expression (expression) of GLT-1 in spinal associated with spinal dorsal horn
12) Confidence 0.41 Published 2009 Journal Mol Pain Section Body Doc Link PMC2676254 Disease Relevance 0.34 Pain Relevance 0.23
Whereas activated astrocytes showed a marked decrease in expression of GLT-1 and GLAST, activated microglia showed de novo expression of GLT-1 and GLAST at 7 days after PSNL and this was maintained through day 14.
Negative_regulation (decrease) of in microglia Gene_expression (expression) of GLT-1 in astrocytes
13) Confidence 0.41 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2676254 Disease Relevance 0.26 Pain Relevance 0.27
This long-term hyperalgesia was accompanied by significant down-regulation of GLT-1 expression in the L4-L6 segments of the spinal dorsal horn, as revealed by immunohistochemistry and Western blot.
Negative_regulation (down-regulation) of Gene_expression (expression) of GLT-1 in dorsal horn associated with hyperalgesia and spinal dorsal horn
14) Confidence 0.41 Published 2010 Journal Pain Section Abstract Doc Link 20022427 Disease Relevance 1.19 Pain Relevance 0.96
Conversely, gene transfer of GLT-1 into spinal cord attenuates inflammatory and neuropathic pain in rats [25]
Negative_regulation (attenuates) of Gene_expression (transfer) of GLT-1 in spinal cord associated with inflammation, neuropathic pain and spinal cord
15) Confidence 0.40 Published 2009 Journal Mol Pain Section Body Doc Link PMC2676254 Disease Relevance 0.52 Pain Relevance 0.47
Decreases in the expression of GLT-1 and GLAST were also found significant in a side to side comparison of the contralateral versus ipsilateral sides of the spinal cord within the PNSL animals (Figure 2E and Figure 3E).
Negative_regulation (Decreases) of Gene_expression (expression) of GLT-1 in spinal cord associated with spinal cord
16) Confidence 0.40 Published 2009 Journal Mol Pain Section Body Doc Link PMC2676254 Disease Relevance 0.24 Pain Relevance 0.15
M), a nontransported inhibitor selective for the glial GLT-1 transporter (IC50 = 23 ?
Negative_regulation (inhibitor) of Gene_expression (glial) of GLT-1
17) Confidence 0.37 Published 2009 Journal Mol Pain Section Body Doc Link PMC2713213 Disease Relevance 0 Pain Relevance 0.24
Interestingly, chronic haloperidol treatment down regulate EAAT2 in the cingulate- and frontal cortex in rats [45], indicating that decreased EAAT2 levels rather may reflect a beneficial condition following the antipsychotic treatment of schizophrenia.
Negative_regulation (decreased) of Gene_expression (levels) of EAAT2 in frontal cortex associated with urological neuroanatomy and schizophrenia
18) Confidence 0.23 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0.74 Pain Relevance 0.53
The expression of GLT-1 mRNA was significantly decreased in the striatum and thalamus of morphine-dependent rats, and significantly increased in the striatum 2 h after the naloxone-precipitated withdrawal, compared with that of naive rats.
Negative_regulation (decreased) of in striatum Gene_expression (expression) of GLT-1 mRNA in thalamus associated with narcan, thalamus, withdrawal and morphine
19) Confidence 0.20 Published 2001 Journal Brain Res. Section Abstract Doc Link 11423104 Disease Relevance 0.17 Pain Relevance 0.97
In addition, concentrations of glutamate and aspartate were higher in baseline-P dialysates than in baseline-B dialysates, and the expression of the GTs (GLT-1, GLAST, and EAAC1) was downregulated by PTX treatment.
Negative_regulation (downregulated) of Gene_expression (expression) of GLT-1 associated with glutamate
20) Confidence 0.13 Published 2008 Journal Brain Res. Section Abstract Doc Link 18680732 Disease Relevance 0.13 Pain Relevance 1.32

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