INT96533

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 72
Total Number 80
Disease Relevance 26.85
Pain Relevance 55.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc1a3)
Anatomy Link Frequency
spinal 9
spinal cord 7
astrocytes 7
neurons 5
glial cells 4
Slc1a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 3480 100.00 Very High Very High Very High
Spinal cord 649 100.00 Very High Very High Very High
Central nervous system 124 100.00 Very High Very High Very High
Catechol-O-methyltransferase 5 100.00 Very High Very High Very High
Antinociceptive 79 99.96 Very High Very High Very High
antinociception 59 99.96 Very High Very High Very High
Pain 518 99.88 Very High Very High Very High
spinal dorsal horn 307 99.84 Very High Very High Very High
Calcitonin gene-related peptide 212 99.74 Very High Very High Very High
Morphine 160 99.66 Very High Very High Very High
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 306 100.00 Very High Very High Very High
Pain 686 99.88 Very High Very High Very High
Nervous System Injury 329 99.74 Very High Very High Very High
Nociception 375 99.48 Very High Very High Very High
Stress 121 99.44 Very High Very High Very High
Hyperalgesia 112 99.28 Very High Very High Very High
Ganglion Cysts 149 98.56 Very High Very High Very High
Injury 89 98.56 Very High Very High Very High
Morphine Dependence 3 98.56 Very High Very High Very High
Bordatella Infection 4 98.46 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Altered discharges of spinal wide dynamic range neurons and down-regulation of glutamate transporter expression in rats with paclitaxel-induced hyperalgesia.
Gene_expression (expression) of glutamate transporter in neurons associated with hyperalgesia, glutamate and wide dynamic range
1) Confidence 0.78 Published 2006 Journal Neuroscience Section Title Doc Link 16361064 Disease Relevance 0.26 Pain Relevance 0.82
The expression of glutamate transporter proteins in the dorsal horn is decreased at the time point corresponding to the physiological changes.
Gene_expression (expression) of glutamate transporter in dorsal horn associated with glutamate and dorsal horn
2) Confidence 0.78 Published 2006 Journal Neuroscience Section Abstract Doc Link 16361064 Disease Relevance 0.25 Pain Relevance 0.80
In conclusion, these data suggest that inhibition of GLAST expression in the spinal cord reduces excitatory synaptic activity and thereby spontaneous responses after nociceptive stimulation of the paw.
Gene_expression (expression) of GLAST in paw associated with nociception and spinal cord
3) Confidence 0.78 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16765320 Disease Relevance 0.81 Pain Relevance 0.54
Changes in the expression of glial glutamate transporters (GLAST and GLT-1) were examined in the spinal cord of rats with chemotherapy (taxol)-induced mechanical hyperalgesia.
Gene_expression (expression) of GLAST in spinal cord associated with hyperalgesia, glutamate, taxol and spinal cord
4) Confidence 0.75 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15975716 Disease Relevance 0.25 Pain Relevance 0.63
Immunohistochemical studies show that the expression of both GLAST and GLT-1 in the L4-L5 spinal dorsal horn is decreased by 24% (P<0.001) and 23% (P<0.001), respectively, in rats with taxol-induced hyperalgesia as compared with those in control rats.
Gene_expression (expression) of GLAST in spinal associated with hyperalgesia, spinal dorsal horn and taxol
5) Confidence 0.75 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15975716 Disease Relevance 0.33 Pain Relevance 0.85
Given the key role played by uptake processes in glutamate neurotransmission, this study examined the effects of nigrostriatal deafferentation and of levodopa treatment on the striatal expression of the glutamate transporters GLT1, GLAST and EAAC1 in the rat.
Gene_expression (expression) of GLAST associated with glutamate and deafferentation
6) Confidence 0.75 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11723182 Disease Relevance 0.09 Pain Relevance 0.23
The expression of mRNAs for the glial glutamate transporters, GLT-1 and GLAST, in the rat brain accompanied with morphine dependence and naloxone-precipitated withdrawal was investigated by Northern blot analysis.
Gene_expression (expression) of GLAST in brain associated with addiction, glutamate, narcan, withdrawal and morphine
7) Confidence 0.75 Published 2001 Journal Brain Res. Section Abstract Doc Link 11423104 Disease Relevance 0.17 Pain Relevance 0.88
In the present study, we examined whether regulation of the glutamate transporter expression with the proposed proteasome inhibitor MG-132 would contribute to the development of tolerance to repeated intrathecal (twice daily x 7 days) morphine administration in rats.
Gene_expression (expression) of glutamate transporter associated with glutamate, tolerance, morphine and intrathecal
8) Confidence 0.71 Published 2008 Journal Pain Section Abstract Doc Link 18986766 Disease Relevance 0.09 Pain Relevance 1.18
Co-administration of amitriptyline with morphine attenuated morphine tolerance and up-regulated GLAST and GLT-1 expression.
Gene_expression (expression) of GLAST associated with tolerance, endep and morphine
9) Confidence 0.69 Published 2006 Journal Pain Section Abstract Doc Link 16697108 Disease Relevance 0 Pain Relevance 1.86
The mechanisms involved may include: (a) inhibition of pro-inflammatory cytokine expression, (b) prevention of glutamate transporter down-regulation, and even up-regulation of glial GTs GLAST and GLT-1 expression, with (c) attenuation of morphine-evoked EAA release following continuous long-term morphine infusion.
Gene_expression (expression) of GLAST associated with glutamate, inflammation, morphine and cytokine
10) Confidence 0.69 Published 2006 Journal Pain Section Abstract Doc Link 16697108 Disease Relevance 0.10 Pain Relevance 1.74
GLAST protein expression was not altered after treatment of rats with either formalin or zymosan.
Gene_expression (expression) of GLAST
11) Confidence 0.68 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16765320 Disease Relevance 0.72 Pain Relevance 0.39
We previously showed that intrathecal co-administration of amitriptyline with morphine upregulates the expression of the glial glutamate transporters glutamate-aspartate transporter (GLAST) and glutamate transporter-1 (GLT-1) and restores neuronal glutamate transporter excitatory amino acid carrier 1 (EAAC1) expression in chronically morphine-infused rats.
Gene_expression (expression) of GLAST in neuronal associated with glutamate, endep, excitatory amino acid, morphine and intrathecal
12) Confidence 0.64 Published 2008 Journal Neuroscience Section Abstract Doc Link 18400403 Disease Relevance 0 Pain Relevance 0.97
We previously showed that intrathecal co-administration of amitriptyline with morphine upregulates the expression of the glial glutamate transporters glutamate-aspartate transporter (GLAST) and glutamate transporter-1 (GLT-1) and restores neuronal glutamate transporter excitatory amino acid carrier 1 (EAAC1) expression in chronically morphine-infused rats.
Gene_expression (expression) of glutamate transporter-1 in neuronal associated with glutamate, endep, excitatory amino acid, morphine and intrathecal
13) Confidence 0.64 Published 2008 Journal Neuroscience Section Abstract Doc Link 18400403 Disease Relevance 0 Pain Relevance 0.98
In conclusion, amitriptyline/morphine co-infusion restores the antinociceptive effect of morphine and upregulates GLAST and GLT-1 expression and restores EAAC1 expression to baseline levels, thus reducing excitatory amino acid levels in the spinal CSF dialysates.
Gene_expression (expression) of GLAST in CSF associated with antinociceptive, endep, excitatory amino acid and morphine
14) Confidence 0.64 Published 2008 Journal Neuroscience Section Abstract Doc Link 18400403 Disease Relevance 0 Pain Relevance 1.43
The present study examined the role of nuclear transcription factor-kappaB (NF-kappaB) in the regulation of the expression of GLAST, GLT-1, and EAAC1 following long-term amitriptyline/morphine co-infusion.
Gene_expression (expression) of GLAST associated with endep and morphine
15) Confidence 0.64 Published 2008 Journal Neuroscience Section Abstract Doc Link 18400403 Disease Relevance 0 Pain Relevance 1.23
Decreases in the expression of GLT-1 and GLAST were also found significant in a side to side comparison of the contralateral versus ipsilateral sides of the spinal cord within the PNSL animals (Figure 2E and Figure 3E).
Gene_expression (expression) of GLAST in spinal cord associated with spinal cord
16) Confidence 0.62 Published 2009 Journal Mol Pain Section Body Doc Link PMC2676254 Disease Relevance 0.24 Pain Relevance 0.15
A novel finding from this work is the observation that PNSL-activated microglia initiate a new expression of GLT-1 and GLAST.
Gene_expression (expression) of GLAST in microglia
17) Confidence 0.62 Published 2009 Journal Mol Pain Section Body Doc Link PMC2676254 Disease Relevance 0.06 Pain Relevance 0.15
Finally, no expression or change in expression of GLT-1 or GLAST was observed in neurons.
Gene_expression (expression) of GLAST in neurons
18) Confidence 0.62 Published 2009 Journal Mol Pain Section Body Doc Link PMC2676254 Disease Relevance 0 Pain Relevance 0.22
Characteristics of synaptically evoked glutamate transporter currents in spinal astrocytes
Gene_expression (currents) of glutamate transporter in spinal associated with glutamate
19) Confidence 0.58 Published 2009 Journal Mol Pain Section Body Doc Link PMC2713213 Disease Relevance 0 Pain Relevance 0.16
EAAT1 (GLAST) is found in
Gene_expression (found) of EAAT1
20) Confidence 0.55 Published 2007 Journal Experimental Diabetes Research Section Body Doc Link PMC1940058 Disease Relevance 1.36 Pain Relevance 0.54

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