INT96542

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Context Info
Confidence 0.51
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 10.72
Pain Relevance 3.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
aorta 2
PSC 2
vessels 1
midbrain 1
motor neuron 1
SMN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
midbrain 2 99.76 Very High Very High Very High
phantom limb 1 99.68 Very High Very High Very High
Cannabinoid receptor 36 98.36 Very High Very High Very High
abdominal pain 8 97.96 Very High Very High Very High
Migraine 5 97.48 Very High Very High Very High
colic 1 97.44 Very High Very High Very High
antagonist 46 96.04 Very High Very High Very High
Cannabinoid 52 93.76 High High
anesthesia 1 93.04 High High
Anterior cingulate cortex 13 92.52 High High
Disease Link Frequency Relevance Heat
Cystadenoma 16 100.00 Very High Very High Very High
Cancer 72 99.90 Very High Very High Very High
Syndrome 49 99.68 Very High Very High Very High
Spinal Muscular Atrophy 9 99.42 Very High Very High Very High
Primary Sclerosing Cholangitis 106 99.14 Very High Very High Very High
Autoimmune Hepatitis 52 98.18 Very High Very High Very High
Abdominal Pain 8 97.96 Very High Very High Very High
Headache 6 97.48 Very High Very High Very High
Abdominal Cramps 1 97.44 Very High Very High Very High
Liver Disease 19 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SMA is caused by the homozygous loss of the SMN1 gene.
Negative_regulation (loss) of SMN1 associated with spinal muscular atrophy
1) Confidence 0.51 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604894 Disease Relevance 0.65 Pain Relevance 0
No deficit was noted at the end of the tumor and SMA removal.
Negative_regulation (removal) of SMA associated with cancer
2) Confidence 0.36 Published 2001 Journal Stereotact Funct Neurosurg Section Abstract Doc Link 12007269 Disease Relevance 0.70 Pain Relevance 0.09
The work being done at the University Georgia to develop motor neuron models to test drug treatments for SMA is just one example.
Negative_regulation (develop) of neuron in motor neuron
3) Confidence 0.20 Published 2008 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2569955 Disease Relevance 0 Pain Relevance 0
Sagittal reconstruction of CT images through the mid-abdomen (Figure 3) showed that the angle between the SMA and the aorta (SMA-aorta angle) was reduced to 16°.
Negative_regulation (reduced) of SMA in aorta
4) Confidence 0.15 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2330058 Disease Relevance 0.74 Pain Relevance 0
In the immunoassay, the tumor cells stained strongly positive for SMA (Fig. 2) and negative for KIT, CD34, and S100.
Negative_regulation (positive) of SMA associated with cancer
5) Confidence 0.13 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2615012 Disease Relevance 0.88 Pain Relevance 0
The first reported case of solid SMA was discovered in a 70 year-old female with a history of diffuse abdominal pain.
Negative_regulation (discovered) of SMA associated with abdominal pain and cystadenoma
6) Confidence 0.12 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1821026 Disease Relevance 1.39 Pain Relevance 0.10
Amputees who experience phantom limb sensations had reduced gray matter in the anterior and posterior cingulate regions, SMA, and midbrain [44].
Negative_regulation (reduced) of SMA in midbrain associated with phantom limb and midbrain
7) Confidence 0.11 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC2935976 Disease Relevance 0.65 Pain Relevance 1.16
The mass displaced the SMA and SMV, but these vessels were patent and uninvolved (Figure 2).
Negative_regulation (displaced) of SMA in vessels
8) Confidence 0.10 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2517072 Disease Relevance 0.50 Pain Relevance 0.03
An arteriography of the abdominal aorta and of splanchnic arteries confirmed patency of CT and IMA, also lack of flow in the SMA.
Negative_regulation (lack) of SMA in abdominal aorta
9) Confidence 0.06 Published 2000 Journal Pol. Arch. Med. Wewn. Section Abstract Doc Link 11424665 Disease Relevance 0.57 Pain Relevance 0.36
CT with 3D reconstruction has been used in SMA syndrome to demonstrate reduction of the angle between the SMA and the aorta [12].
Negative_regulation (reduction) of SMA in aorta associated with syndrome
10) Confidence 0.06 Published 2010 Journal World J Emerg Surg Section Body Doc Link PMC2843665 Disease Relevance 1.13 Pain Relevance 0.05
Among patients with autoimmune hepatitis, 35 (92.1%) were of type 1, none of type 2 and the rest 3 could not be classified as they lacked the SMA and ANA.
Negative_regulation (lacked) of SMA associated with autoimmune hepatitis
11) Confidence 0.02 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1236920 Disease Relevance 0.95 Pain Relevance 0.05
Incubation of RLT-PSC cells and primary human activated PSC on Matrigel plus NAC treatment resulted in a deactivated phenotype as evidenced by a decrease of alphaSMA, connective tissue growth factor and Col I expression and by a decreased proliferation of the cells.
Negative_regulation (decrease) of alphaSMA in PSC associated with primary sclerosing cholangitis
12) Confidence 0.01 Published 2005 Journal Lab. Invest. Section Abstract Doc Link 16127427 Disease Relevance 0.98 Pain Relevance 0.04
Furthermore, WIN induced a reduction in alphaSMA levels which was also partially reversed by pre-incubation with a combination of both CB-receptor antagonists (Figure 7B; equal loading: gamma-tubulin).


Negative_regulation (reduction) of alphaSMA associated with antagonist
13) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.35 Pain Relevance 0.21
Activation of cannabinoid receptors, however, induced de-activation of PSC and dose-dependently inhibited growth and decreased IL-6 and MCP-1 secretion as well as fibronectin, collagen1 and alphaSMA levels.
Negative_regulation (decreased) of alphaSMA in PSC associated with cannabinoid receptor and primary sclerosing cholangitis
14) Confidence 0.00 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2253501 Disease Relevance 1.22 Pain Relevance 1.03

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