INT9655

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Context Info
Confidence 0.62
First Reported 1992
Last Reported 2011
Negated 19
Speculated 9
Reported most in Body
Documents 98
Total Number 107
Disease Relevance 70.92
Pain Relevance 31.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) extracellular region (Il6)
Anatomy Link Frequency
liver 3
plasma 2
macrophages 2
fat 2
lung 2
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1595 100.00 Very High Very High Very High
cytokine 1436 100.00 Very High Very High Very High
rheumatoid arthritis 443 100.00 Very High Very High Very High
Morphine 307 100.00 Very High Very High Very High
Inflammatory mediators 89 100.00 Very High Very High Very High
cINOD 87 100.00 Very High Very High Very High
Paracetamol 16 99.84 Very High Very High Very High
chemokine 189 99.82 Very High Very High Very High
metalloproteinase 55 99.80 Very High Very High Very High
Inflammatory response 203 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1864 100.00 Very High Very High Very High
Cancer 689 100.00 Very High Very High Very High
Rheumatoid Arthritis 512 100.00 Very High Very High Very High
Arthritis 273 100.00 Very High Very High Very High
Hypoxia 184 100.00 Very High Very High Very High
Necrosis 122 100.00 Very High Very High Very High
Thrombosis Related Under Development 26 100.00 Very High Very High Very High
Appetite Loss 7 100.00 Very High Very High Very High
Burns 70 99.98 Very High Very High Very High
Chlamydia Infection 74 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment of mice with pristane may provide a model system for studying the inflammatory pathways that control IL-6 levels in vivo.
Regulation (control) of IL-6 associated with inflammation
1) Confidence 0.62 Published 1992 Journal Blood Section Abstract Doc Link 1611085 Disease Relevance 0.40 Pain Relevance 0.17
In this study, we used two different HD exposure models to determine the in vivo cutaneous response of the inflammatory cytokines interleukin-6 (IL-6), IL-1alpha, IL-1beta and tumor necrosis factor alpha (TNF-alpha), in order to identify a suitable inflammatory biomarker common to both models.
Regulation (response) of interleukin-6 associated with necrosis, inflammation, cancer and cytokine
2) Confidence 0.62 Published 2000 Journal J Appl Toxicol Section Abstract Doc Link 11428647 Disease Relevance 0.98 Pain Relevance 0.44
In this study, we used two different HD exposure models to determine the in vivo cutaneous response of the inflammatory cytokines interleukin-6 (IL-6), IL-1alpha, IL-1beta and tumor necrosis factor alpha (TNF-alpha), in order to identify a suitable inflammatory biomarker common to both models.
Regulation (response) of IL-6 associated with necrosis, inflammation, cancer and cytokine
3) Confidence 0.62 Published 2000 Journal J Appl Toxicol Section Abstract Doc Link 11428647 Disease Relevance 1.03 Pain Relevance 0.44
Pretreatment of mice with dexamethasone (0.3-30.0 mg/kg, i.p., 30 min before endotoxin) completely blocked TNF production but did not affect that of IL-6.
Neg (not) Regulation (affect) of IL-6 associated with dexamethasone
4) Confidence 0.61 Published 1992 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 1428359 Disease Relevance 0.42 Pain Relevance 0.33
The reader needs to be reminded that the data presented is preliminary and that further investigation is necessary in order to better elucidate the differential regulation of IL-6, MIP-2, and KC, as a result of gender dimorphism during hepatic I/R.
Regulation (regulation) of IL-6
5) Confidence 0.47 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1764413 Disease Relevance 0.22 Pain Relevance 0.20
The mechanisms by which basal IL-6 levels affect pulmonary vascular remodeling and inflammation remain unclear.
Regulation (affect) of IL-6 associated with inflammation
6) Confidence 0.45 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 1.17 Pain Relevance 0.36
IL-6 elevation reported during acute hypoxia was suggested to affect lung vascular permeability and the early inflammatory response to hypoxia [19,20].
Regulation (affect) of IL-6 in lung associated with inflammatory response and hypoxia
7) Confidence 0.45 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 2.04 Pain Relevance 0.15
When analyzing the effects of direct addition of IL-6 on superoxide production in synaptosomes, IL-6 (100 ng/ml, final) was added to synaptosomes 5 minutes before Nox oxidase activity was initiated by addition of substrate (NADPH,5 mM final).
Spec (analyzing) Regulation (effects) of IL-6
8) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0 Pain Relevance 0
B activation, expression of these two cytokines, measured by RT-qPCR, was not statistically different between old wild-type and old IL-6-/- mice (data not shown) suggesting that the specific loss of IL-6 expression, not changes in these other cytokines, was responsible for decreased nuclear NF?
Neg (not) Regulation (different) of IL-6 associated with cytokine
9) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.21 Pain Relevance 0.14
Neither anti-IL-6 antibody nor rhuIFN alpha had a direct growth-inhibitory effect on the AB22 mesothelioma cell line in vitro, however, in vivo rhuIFN alpha treatment of mice inoculated with AB22 cells attenuated both IL-6 mRNA expression in the tumours and serum IL-6 levels, ameliorated the depression of lymphocyte activities, and enhanced the number of tumour-infiltrating lymphocytes and macrophages.
Regulation (levels) of IL-6 in macrophages associated with lung cancer, depression and cancer
10) Confidence 0.45 Published 1995 Journal Cancer Immunol. Immunother. Section Abstract Doc Link 7750122 Disease Relevance 1.03 Pain Relevance 0.16
Inhibitory effects of anti-inflammatory drugs on interleukin-6 bioactivity.
Regulation (effects) of interleukin-6 associated with inflammation and cinod
11) Confidence 0.45 Published 2001 Journal Biol. Pharm. Bull. Section Title Doc Link 11411563 Disease Relevance 0.61 Pain Relevance 0.67
Inhibitory effects of anti-inflammatory drugs on IL-6 bioactivity using IL-6-dependent hybridoma have been evaluated.
Regulation (effects) of IL-6 associated with inflammation and cinod
12) Confidence 0.45 Published 2001 Journal Biol. Pharm. Bull. Section Abstract Doc Link 11411563 Disease Relevance 0.54 Pain Relevance 0.56
These data indicate that IL-6 and TNF production are differently susceptible to glucocorticoids, and that prostaglandins can physiologically provide a negative feedback regulation of IL-6 and TNF synthesis.
Regulation (regulation) of IL-6
13) Confidence 0.44 Published 1992 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 1428359 Disease Relevance 0.37 Pain Relevance 0.31
Effect of chronic IL-6 infusion on acute pressor responses to vasoconstrictors in mice.
Regulation (Effect) of IL-6
14) Confidence 0.44 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Title Doc Link 17557918 Disease Relevance 0.16 Pain Relevance 0.15
Genes promoting immune responses were down-regulated, including genes for the proinflammatory/Th2 cytokines IL-1b, IL-4, IL-6, IL-10, IL-13, and TNF-?.
Regulation (regulated) of IL-6 associated with cytokine
15) Confidence 0.43 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137099 Disease Relevance 1.03 Pain Relevance 0.51
Since PGE2 has an opposite effect on TNF and IL-6 production, inhibiting that of TNF but inducing that of IL-6, we investigated the effect of S-KPF on TNF and IL-6 production in vivo following LPS injection.
Regulation (effect) of IL-6
16) Confidence 0.42 Published 2000 Journal Cytokine Section Abstract Doc Link 10930297 Disease Relevance 0.08 Pain Relevance 0.12
Overall, these findings demonstrate that IL-6 has an important role in the development of the adaptive immune response and may be involved in the pathogenesis of RA.


Regulation (role) of IL-6 associated with rheumatoid arthritis
17) Confidence 0.41 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 1.27 Pain Relevance 0.20
Furthermore, it was demonstrated that IL-6-induced thrombocytosis in mice is accompanied by enhanced hepatic TPO mRNA expression and elevated TPO plasma levels [20].
Regulation (accompanied) of IL-6 in plasma associated with thrombosis related under development
18) Confidence 0.39 Published 2010 Journal BMC Dermatol Section Body Doc Link PMC2860341 Disease Relevance 1.00 Pain Relevance 0.29
Similar to the retinal tissue, the level of IL-6 was undetectable in the RPE-choroid complex of control animals (Figure 4B).
Regulation (undetectable) of IL-6 in choroid
19) Confidence 0.37 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 0.83 Pain Relevance 0.10
Indeed, paralleling the BrdU variations, repeated but not a single IL-6 infusion provoked intense immunoreactivity for the microglial marker, CD11b, within the CA1 hippocampal region, directly above the granule cell layer of the dentate gyrus (Figure 4).
Neg (not) Regulation (single) of IL-6 in dentate gyrus
20) Confidence 0.36 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695223 Disease Relevance 0.12 Pain Relevance 0.19

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