INT96557

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Context Info
Confidence 0.47
First Reported 2001
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 46
Total Number 49
Disease Relevance 21.74
Pain Relevance 24.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
brain 7
neurons 5
hippocampus 2
spinal 2
spinal cord 2
Bdnf (Rattus norvegicus)
Bdnf - V66M (1)
Pain Link Frequency Relevance Heat
bDMF 1081 100.00 Very High Very High Very High
Pain 150 100.00 Very High Very High Very High
antagonist 62 100.00 Very High Very High Very High
long-term potentiation 60 100.00 Very High Very High Very High
dorsal root ganglion 49 100.00 Very High Very High Very High
spinal dorsal horn 9 100.00 Very High Very High Very High
antidepressant 197 99.98 Very High Very High Very High
Hippocampus 182 99.92 Very High Very High Very High
Nerve growth factor 249 99.80 Very High Very High Very High
depression 169 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 178 100.00 Very High Very High Very High
Death 66 100.00 Very High Very High Very High
Depression 405 99.76 Very High Very High Very High
Pain 181 99.76 Very High Very High Very High
Frailty 21 99.48 Very High Very High Very High
Pancreatitis 16 99.44 Very High Very High Very High
Neuropathic Pain 109 99.40 Very High Very High Very High
Injury 201 99.20 Very High Very High Very High
Hypoactive Sexual Desire Disorder 2 99.16 Very High Very High Very High
Brain Injury 30 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The authors' results suggest that this shift relies on an interaction with Gs-proteins and BDNF.


BDNF Binding (interaction) of
1) Confidence 0.47 Published 2010 Journal Anesthesiology Section Body Doc Link 20613480 Disease Relevance 0 Pain Relevance 0
Using in situ hybridization with exon-specific riboprobes, we have examined whether diverse classes of antidepressants recruit a single or multiple BDNF promoters to regulate BDNF mRNAs.
BDNF Spec (whether) Binding (recruit) of associated with antidepressant and bdmf
2) Confidence 0.46 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12907316 Disease Relevance 0.34 Pain Relevance 0.72
It still remains to be determined whether BDNF antagonist (or inhibitor) can interact with other analgesia or not.
BDNF Binding (interact) of associated with antagonist, bdmf and analgesia
3) Confidence 0.42 Published 2008 Journal Mol Pain Section Body Doc Link PMC2492846 Disease Relevance 1.09 Pain Relevance 1.94
However, the precursor form of BDNF (pro-BDNF) can also precipitate reduction in dendritic spines and cell death when it binds with the p75 receptor.
pro-BDNF Binding (binds) of in spines associated with death
4) Confidence 0.40 Published 2007 Journal International Journal of Clinical Practice Section Body Doc Link PMC2228409 Disease Relevance 1.00 Pain Relevance 0.63
However, the precursor form of BDNF (pro-BDNF) can also precipitate reduction in dendritic spines and cell death when it binds with the p75 receptor.
BDNF Binding (binds) of in spines associated with death
5) Confidence 0.40 Published 2007 Journal International Journal of Clinical Practice Section Body Doc Link PMC2228409 Disease Relevance 1.00 Pain Relevance 0.63
Several events associated with BDNF-LTP in the dentate gyrus are induced by chronic antidepressant treatment.
BDNF-LTP Binding (associated) of in dentate gyrus associated with antidepressant and long-term potentiation
6) Confidence 0.38 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC2248427 Disease Relevance 0.06 Pain Relevance 0.56
The BDNF gene is rather complex in its structure and it can express four different mRNA isoforms by alternative splicing, each producing the same protein.
BDNF gene Binding (complex) of
7) Confidence 0.37 Published 2004 Journal Brain Res. Section Abstract Doc Link 15053962 Disease Relevance 0.16 Pain Relevance 0.25
In the deep dorsal horn (lamina III and IV), considerable increased intensity of BDNF-IR was also observed in the neurons (Table 1).
BDNF-IR Binding (intensity) of in neurons associated with dorsal horn and bdmf
8) Confidence 0.37 Published 2008 Journal Mol Pain Section Body Doc Link PMC2492846 Disease Relevance 0.38 Pain Relevance 1.00
The rat BDNF gene itself is complex and expresses four different mRNA isoforms which can be regulated by different signaling cascades.
BDNF Binding (complex) of
9) Confidence 0.37 Published 2006 Journal Brain Res. Section Abstract Doc Link 16842762 Disease Relevance 0.09 Pain Relevance 0.25
Vaynman et al. (27) reported that exercise-induced increases in synapsin I and synaptophysin in the hippocampus were abrogated by blocking of interaction between BDNF and the BDNF receptor TrkB.
BDNF Binding (interaction) of in hippocampus associated with hippocampus
10) Confidence 0.37 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967002 Disease Relevance 0.15 Pain Relevance 0.14
Vaynman et al. (27) reported that exercise-induced increases in synapsin I and synaptophysin in the hippocampus were abrogated by blocking of interaction between BDNF and the BDNF receptor TrkB.
BDNF Binding (interaction) of in hippocampus associated with hippocampus
11) Confidence 0.37 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967002 Disease Relevance 0.15 Pain Relevance 0.14
In the present study we examined the potential interaction between CREB and BDNF in the spinal dorsal horn.
BDNF Spec (examined) Binding (interaction) of in dorsal horn associated with spinal dorsal horn
12) Confidence 0.37 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15135945 Disease Relevance 0.19 Pain Relevance 0.30
For example, a reciprocal interaction between interleukin-6 and BDNF may play important roles in the enhanced regeneration after conditioning sciatic nerve lesion [54].
BDNF Binding (interaction) of in sciatic nerve associated with sciatic nerve and bdmf
13) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2246162 Disease Relevance 0.26 Pain Relevance 0.45
We propose that BDNF, whose synthesis is increased by antidepressants, and which is in part released at synaptic sites, binds to TrkB in PSDs, leading to the internalization of the BDNF-TrkB complex and, thus, to a decrease of TrkB in the PSDs.
BDNF-TrkB Binding (leading) of associated with antidepressant
14) Confidence 0.35 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16554746 Disease Relevance 0 Pain Relevance 0.50
We propose that BDNF, whose synthesis is increased by antidepressants, and which is in part released at synaptic sites, binds to TrkB in PSDs, leading to the internalization of the BDNF-TrkB complex and, thus, to a decrease of TrkB in the PSDs.
BDNF-TrkB Binding (leading) of associated with antidepressant
15) Confidence 0.35 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16554746 Disease Relevance 0 Pain Relevance 0.50
Interestingly, BDNF has been shown to have a trophic effect on serotoninergic neurons [18] and in general to interact with the serotoninergic system [17].
BDNF Binding (interact) of in neurons associated with bdmf
16) Confidence 0.35 Published 2005 Journal Ann Gen Psychiatry Section Body Doc Link PMC1090442 Disease Relevance 0.78 Pain Relevance 0.29
We performed co-localization analysis on neurons and vibratome sections to study the interaction of proteins with BDNF mRNA.
BDNF Binding (interaction) of in neurons
17) Confidence 0.34 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0
However, a combination of BDNF and GDNF (but not with NT-3 or NGF) given either 60 or 90 min after SCI significantly reduced the motor dysfunction and spinal cord pathology at 5 h.
BDNF Neg (not) Binding (combination) of in spinal cord associated with frailty and spinal cord
18) Confidence 0.33 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 18077567 Disease Relevance 1.14 Pain Relevance 0.40
Resolution of allodynia after treadmill training was associated with normal mRNA levels of brain-derived neurotrophic factor (BDNF) in both the lumbar spinal cord and soleus muscle.
brain-derived neurotrophic factor Binding (associated) of in spinal cord associated with allodynia and spinal cord
19) Confidence 0.33 Published 2004 Journal Brain Section Abstract Doc Link 15069022 Disease Relevance 1.06 Pain Relevance 0.96
The main findings of the present study are: (1) a biphasic activation of hippocampal mTOR signaling is associated with IA training and is required for its memory formation; (2) activation of the mTOR cascade in the dorsal hippocampus is initiated by BDNF; (3) previously synthesized BDNF is rapidly released immediately after IA training whereas around 3 h after training, new synthesis of BDNF protein is needed for LTM formation; (4) learning related BDNF/mTOR cascade activation after training induces GluR1 expression in hippocampal synaptic plasma membranes; and (5) GluR1 translation during training or 3 h later is required for IA memory consolidation.
BDNF Binding (initiated) of in plasma associated with hippocampus
20) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.05

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