INT9656

Context Info Confidence 0.62 First Reported 1992 Last Reported 2011 Negated 7 Speculated 10 Reported most in Body Documents 57 Total Number 68 Disease Relevance 33.30 Pain Relevance 17.71

extracellular space (Il6) extracellular region (Il6)

Anatomy Link Frequency macrophages 9 decidua 4 T cells 4 monocytes 3 liver 3 Il6 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 1298 100.00 cytokine 720 100.00 cINOD 46 100.00 Morphine 25 100.00 dexamethasone 10 100.00 Nerve growth factor 10 100.00 Enkephalin 9 100.00 Opioid 3 100.00 Inflammatory mediators 26 99.98 chemokine 174 99.92

Disease Link Frequency Relevance Heat INFLAMMATION 1416 100.00 Cancer 409 100.00 Necrosis 159 100.00 Reprotox - General 1 40 100.00 Appetite Loss 6 100.00 Arthritis 161 99.86 Stress 81 99.76 Infection 83 99.68 Primary Pulmonary Hypertension 144 99.60 Apoptosis 112 99.58

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This polymorphism influences the levels of circulating IL-6, suggesting a causal role for high circulating IL-6 levels in the pathogenesis of PH in patients with COPD.

Regulation (role) of Gene_expression (levels) of IL-6 associated with pulmonary disease and primary pulmonary hypertension

1) Confidence 0.62 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 1.72 Pain Relevance 0.33

The rise in IL-6 protein lasted up to 7 days, and PH developed within 2 weeks in hypoxic mice, allowing us to evaluate whether changes in IL-6 expression affected PH development in our model.

Spec (whether) Regulation (changes) of Gene_expression (expression) of IL-6 associated with primary pulmonary hypertension and hypoxia

2) Confidence 0.62 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 1.34 Pain Relevance 0

These data indicate that IL-6 and TNF production are differently susceptible to glucocorticoids, and that prostaglandins can physiologically provide a negative feedback regulation of IL-6 and TNF synthesis.

Regulation (regulation) of Gene_expression (synthesis) of IL-6

3) Confidence 0.61 Published 1992 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 1428359 Disease Relevance 0.37 Pain Relevance 0.31

The effect of dexamethasone and two non-steroidal anti-inflammatory agents ibuprofen and indomethacin on the production of serum interleukin 6(IL-6) and tumor necrosis factor (TNF) levels in mice treated with endotoxin (2.5 micrograms/mouse, i.p.) was investigated.

Spec (investigated) Regulation (effect) of Spec (investigated) Gene_expression (production) of IL-6 associated with necrosis, inflammation, cancer and dexamethasone

4) Confidence 0.61 Published 1992 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 1428359 Disease Relevance 0.43 Pain Relevance 0.30

Lung immunohistochemical labeling of IL-6 and macrophages

Regulation (Lung) of Gene_expression (immunohistochemical) of IL-6 in macrophages

5) Confidence 0.45 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.07 Pain Relevance 0

, this is to our knowledge, the first report that IL-6 acting through non-canonical NF?

Regulation (report) of Gene_expression (acting) of IL-6

6) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.26 Pain Relevance 0.07

Age-related increased superoxide production in brain in vivo is attenuated by inhibition of NADPH oxidase or by treatment with a superoxide dismutase mimetic, and is emulated by increased levels of plasma IL-6

Regulation (emulated) of Gene_expression (levels) of IL-6 in plasma

7) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0 Pain Relevance 0.10

B activation, expression of these two cytokines, measured by RT-qPCR, was not statistically different between old wild-type and old IL-6-/- mice (data not shown) suggesting that the specific loss of IL-6 expression, not changes in these other cytokines, was responsible for decreased nuclear NF?

Neg (not) Regulation (different) of Gene_expression (type) of IL-6 associated with cytokine

8) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.21 Pain Relevance 0.14

A murine model of malignant mesothelioma was therefore used to examine the potential role of IL-6 in this cancer type and whether the effect of interferon alpha (IFN alpha) therapy on mesothelioma might be mediated, in part, by regulating IL-6 levels and/or IL-6-induced pathobiology.

Regulation (regulating) of Gene_expression (levels) of IL-6 associated with malignant neoplastic disease, lung cancer and cancer

9) Confidence 0.45 Published 1995 Journal Cancer Immunol. Immunother. Section Abstract Doc Link 7750122 Disease Relevance 1.34 Pain Relevance 0

A murine model of preterm labor: inflammatory mediators regulate the production of prostaglandin E2 and interleukin-6 by murine decidua.

Regulation (regulate) of Gene_expression (production) of interleukin-6 in decidua associated with inflammatory mediators, inflammation and pre-term labor

10) Confidence 0.43 Published 1993 Journal Biol. Reprod. Section Title Doc Link 8418915 Disease Relevance 0.98 Pain Relevance 0.43

B-regulated expression of Tnf, Il6, Ccl2, Ccl5, Cxcl10, and Icam1 [22] were significantly reduced in Tlr4 KO versus WT retinas, suggesting that the neuroprotective effect is in part due to Tlr4-NF-?

Regulation (regulated) of Gene_expression (expression) of Il6 in retinas

11) Confidence 0.43 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956702 Disease Relevance 0.97 Pain Relevance 0.35

Augmenting effect of methionine-enkephalin on interleukin-6 production by cytokine-stimulated murine macrophages.

Regulation (effect) of Gene_expression (production) of interleukin-6 in macrophages associated with enkephalin and cytokine

12) Confidence 0.43 Published 2000 Journal Neuropeptides Section Title Doc Link 11021979 Disease Relevance 0 Pain Relevance 0.83

Since PGE2 has an opposite effect on TNF and IL-6 production, inhibiting that of TNF but inducing that of IL-6, we investigated the effect of S-KPF on TNF and IL-6 production in vivo following LPS injection.

Spec (investigated) Regulation (effect) of Gene_expression (production) of IL-6

13) Confidence 0.42 Published 2000 Journal Cytokine Section Abstract Doc Link 10930297 Disease Relevance 0.09 Pain Relevance 0.13

Since PGE2 has an opposite effect on TNF and IL-6 production, inhibiting that of TNF but inducing that of IL-6, we investigated the effect of S-KPF on TNF and IL-6 production in vivo following LPS injection.

Regulation (effect) of Gene_expression (production) of IL-6

14) Confidence 0.42 Published 2000 Journal Cytokine Section Abstract Doc Link 10930297 Disease Relevance 0.08 Pain Relevance 0.12

Heparin therapy significantly decreased TAT3 levels but did not alter the profile of GRO-1 or IL-6 protein levels seen with venous occlusion.

Regulation (profile) of Gene_expression (levels) of IL-6 protein

15) Confidence 0.41 Published 2009 Journal Ann Vasc Surg Section Abstract Doc Link 18640815 Disease Relevance 0.76 Pain Relevance 0.35

Serum levels of the inflammatory cytokines IL-1beta and IL-6, mediators of cachexia, were modulated by NSAIDs.

Regulation (modulated) of Gene_expression (levels) of IL-6 associated with appetite loss, inflammation, cinod and cytokine

16) Confidence 0.39 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 15170663 Disease Relevance 1.94 Pain Relevance 0.48

PEITC has been shown to suppress STAT3 activation [26] but its direct effect on IL6 expression has not been reported.

Regulation (effect) of Gene_expression (expression) of IL6

17) Confidence 0.39 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.55 Pain Relevance 0.17

This bioassay was based on the IL-6 production induced by the combination of TNF-?

Regulation (based) of Gene_expression (production) of IL-6

18) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064892 Disease Relevance 0.07 Pain Relevance 0.08

The IL-6 expression was found in patches and at low levels in the Skov-3 only tumors.

Regulation (found) of Gene_expression (expression) of IL-6 associated with cancer

19) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 1.29 Pain Relevance 0

The effects of taurine (T) and niacin (N) on bleomycin (BL)-induced increased production of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1alpha, IL-6, and transforming growth factor-beta (TGF-beta) levels in the bronchoalveolar lavage fluid (BALF), and increased collagen content and nuclear factor-kappaB (NF-kappaB) activation in the lungs were investigated in mice.

Spec (investigated) Regulation (effects) of Gene_expression (production) of IL-6 in lungs associated with necrosis and cancer

20) Confidence 0.34 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10734156 Disease Relevance 0.35 Pain Relevance 0.15

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