INT96569

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Context Info
Confidence 0.32
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.08
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CHEK1) nucleoplasm (CHEK1) cytoskeleton (CHEK1)
nucleus (CHEK1) cell cycle (CHEK1) cytoplasm (CHEK1)
Anatomy Link Frequency
stem cells 1
CHEK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 1 84.00 Quite High
drug abuse 57 64.44 Quite High
alcohol 4 61.76 Quite High
addiction 3 61.12 Quite High
palliative 1 58.92 Quite High
cocaine 28 51.84 Quite High
cannabis 16 51.12 Quite High
depression 2 33.24 Quite Low
Opioid 3 14.04 Low Low
long-term potentiation 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dna Damage 1 99.84 Very High Very High Very High
Glioma 8 99.12 Very High Very High Very High
Apoptosis 9 96.84 Very High Very High Very High
Cancer 11 95.64 Very High Very High Very High
Glioblastoma 2 88.84 High High
Recurrence 1 85.04 High High
Pressure Volume 2 Under Development 1 84.00 Quite High
Headache 1 84.00 Quite High
Diarrhoea 1 83.36 Quite High
Vomiting 1 83.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the radioresistance of CD133-positive glioma stem cells can be reversed with a specific inhibitor of the Chk1 and Chk2 checkpoint kinases.
Negative_regulation (inhibitor) of Chk1 in stem cells associated with glioma
1) Confidence 0.32 Published 2006 Journal Nature Section Abstract Doc Link 17051156 Disease Relevance 1.65 Pain Relevance 0.06
These two relationships are illustrated in Figure 7 where we see ATM activating CHK1, CHK2 and MDM2 inhibiting p53.
Negative_regulation (inhibiting) of CHK1
2) Confidence 0.23 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC2944280 Disease Relevance 0 Pain Relevance 0
An additional 113 transcripts were significantly changed in Groups I–II only; 44 transcripts, including FIBP, VTN, STOM, ICAM1, SEMA3B, RARG, RARA, were increased, and 68 transcripts, including APOL1, CALM1, CALM2, CAMK2B, GNB2L1, HINT1, RAB9A, CHEK1, PPP2CA and NFKBIA, were decreased.
Negative_regulation (decreased) of CHEK1
3) Confidence 0.11 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.13 Pain Relevance 0.15
Moreover, UCN-01 may abrogate checkpoints induced by genotoxic stress due to inhibition of chk1 kinase.
Negative_regulation (inhibition) of chk1 kinase associated with dna damage
4) Confidence 0.10 Published 2000 Journal Oncogene Section Abstract Doc Link 11426645 Disease Relevance 1.30 Pain Relevance 0.08

General Comments

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