INT9657

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Context Info
Confidence 0.70
First Reported 1992
Last Reported 2011
Negated 6
Speculated 11
Reported most in Body
Documents 237
Total Number 248
Disease Relevance 180.45
Pain Relevance 63.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) extracellular region (Il6)
Anatomy Link Frequency
plasma 20
lung 18
macrophage 17
brain 16
monocytes 16
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 4323 100.00 Very High Very High Very High
cytokine 3284 100.00 Very High Very High Very High
Arthritis 583 100.00 Very High Very High Very High
Inflammatory response 542 100.00 Very High Very High Very High
chemokine 507 100.00 Very High Very High Very High
Morphine 162 100.00 Very High Very High Very High
metalloproteinase 140 100.00 Very High Very High Very High
Nerve growth factor 34 100.00 Very High Very High Very High
Enkephalin 31 100.00 Very High Very High Very High
COX2 8 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 4899 100.00 Very High Very High Very High
Disease 1785 100.00 Very High Very High Very High
Hypoxia 1150 100.00 Very High Very High Very High
Cancer 1056 100.00 Very High Very High Very High
Infection 1045 100.00 Very High Very High Very High
Arthritis 607 100.00 Very High Very High Very High
Necrosis 406 100.00 Very High Very High Very High
Adhesions 298 100.00 Very High Very High Very High
Urological Neuroanatomy 42 100.00 Very High Very High Very High
Myocardial Infarction 23 99.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By using the B9 cell bioassay, it was found that injection of pristane caused a marked and prolonged elevation of interleukin-6 (IL-6) levels in the peritoneal cavities of the mice.
Positive_regulation (caused) of Gene_expression (levels) of interleukin-6 in cavities
1) Confidence 0.70 Published 1992 Journal Blood Section Abstract Doc Link 1611085 Disease Relevance 0.37 Pain Relevance 0.13
The expression of IL-6 was increased by vincristine administration and was co-localized in the invading macrophage.
Positive_regulation (increased) of Gene_expression (expression) of IL-6 in macrophage associated with vincristine
2) Confidence 0.70 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18652822 Disease Relevance 0.81 Pain Relevance 1.25
Short-term exposure of PA-SMCs to hypoxia also markedly stimulated IL-6 expression, suggesting that PA-SMCs may represent a major source of IL-6 in the lung, especially during the development of hypoxic PH.
Positive_regulation (stimulated) of Gene_expression (expression) of IL-6 in lung associated with primary pulmonary hypertension and hypoxia
3) Confidence 0.70 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 1.36 Pain Relevance 0.03
In these studies, hypoxia induced IL-6 expression via enhanced transcription driven by the nuclear factor IL-6 site in the IL-6 promoter.
Positive_regulation (induced) of Gene_expression (expression) of IL-6 associated with hypoxia
4) Confidence 0.70 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 1.39 Pain Relevance 0
Moreover, IL-6 expression seems increased in many types of human and experimental PH, including monocrotaline-induced PH in rats, suggesting that IL-6 may modulate the extent of PH despite the absence of a hypoxic pulmonary vasoconstrictor component.
Spec (seems) Positive_regulation (increased) of Gene_expression (expression) of IL-6 associated with primary pulmonary hypertension and hypoxia
5) Confidence 0.70 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 1.40 Pain Relevance 0.28
Thus, exposure to chronic hypoxia is associated not only with a large increase in lung IL-6 levels, but also with increased expression of the IL-6 receptor.
Positive_regulation (increased) of Gene_expression (expression) of IL-6 in lung associated with hypoxia
6) Confidence 0.70 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 1.57 Pain Relevance 0
Reduction of lipopolysaccharide-induced interleukin-6 production by the kappa opioid U50,488 in a mouse monocyte-like cell line.
Positive_regulation (induced) of Gene_expression (production) of interleukin-6 in monocyte associated with opioid
7) Confidence 0.70 Published 2006 Journal Int. Immunopharmacol. Section Title Doc Link 16644488 Disease Relevance 0.26 Pain Relevance 0.68
Pretreatment with U50,488 significantly reduced LPS-stimulated interleukin-6 (IL-6) production as measured by ELISA.
Positive_regulation (stimulated) of Gene_expression (production) of interleukin-6
8) Confidence 0.70 Published 2006 Journal Int. Immunopharmacol. Section Abstract Doc Link 16644488 Disease Relevance 0.25 Pain Relevance 0.79
Conversely, pretreatment with indomethacin (5 mg/kg, i.p.) or ibuprofen (30 mg/kg, i.p.) potentiated the production of both IL-6 (+ 80% with INDO; + 100% with IBU) and TNF (+ 500% with INDO; + 50% with IBU).
Positive_regulation (potentiated) of Gene_expression (production) of IL-6
9) Confidence 0.68 Published 1992 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 1428359 Disease Relevance 0.42 Pain Relevance 0.34
Likewise, IL-6 production by macrophages was significantly augmented by exposure to these three peptides.
Positive_regulation (augmented) of Gene_expression (production) of IL-6 in macrophages
10) Confidence 0.66 Published 1996 Journal Peptides Section Abstract Doc Link 8822513 Disease Relevance 0.08 Pain Relevance 0.34
Anti-TNF antibodies inhibited LPS-induced IL-6 production in three different models: IL-6 production by mouse peritoneal macrophages in vitro; serum IL-6 levels induced by intraperitoneal LPS; and brain IL-6 levels induced by an intracerebroventricular injection of LPS.
Positive_regulation (-) of Gene_expression (production) of IL-6 in brain associated with intracerebroventricular
11) Confidence 0.65 Published 2000 Journal Cytokine Section Abstract Doc Link 10930297 Disease Relevance 0 Pain Relevance 0.05
Both TNF and IL-6 induction was augmented by S-KPF, but anti-TNF antibodies abolished the augmentation of IL-6 production.
Positive_regulation (augmentation) of Gene_expression (production) of IL-6
12) Confidence 0.65 Published 2000 Journal Cytokine Section Abstract Doc Link 10930297 Disease Relevance 0.10 Pain Relevance 0.14
expression in circulatory leukocytes and this might be sufficient to induce IL-6 production in some tissues [27].
Positive_regulation (induce) of Gene_expression (production) of IL-6 in leukocytes
13) Confidence 0.60 Published 2010 Journal BMC Dermatol Section Body Doc Link PMC2860341 Disease Relevance 0.35 Pain Relevance 0.07
Moreover cyclosporine-upregulated IL-6 gene expression in vivo, may explain in part the molecular mechanisms responsible for cyclosporine -induced gingival overgrowth [26].
Positive_regulation (upregulated) of Gene_expression (expression) of IL-6 gene associated with gingival overgrowth
14) Confidence 0.60 Published 2010 Journal BMC Dermatol Section Body Doc Link PMC2860341 Disease Relevance 0.41 Pain Relevance 0.09
Effective recruitment of neutrophils into the cornea is dependent on the production of IL-6, and IL-6 has been demonstrated to be a protective factor in corneal infection [27].
Positive_regulation (dependent) of Gene_expression (production) of IL-6 in cornea associated with infection
15) Confidence 0.54 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 1.25 Pain Relevance 0.28
Increased expression of IL-6 at the late stage (seven days post-infection) may play a role in stimulating lymphocyte activation, proliferation, and differentiation, and it may be important in promoting the humoral and cellular immune responses.
Positive_regulation (Increased) of Gene_expression (expression) of IL-6 in lymphocyte associated with infection
16) Confidence 0.54 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 1.26 Pain Relevance 0.23
These GBM-M2 lines grew more aggressively orthotopically and all showed dramatic multifold increases in IL6, IL8, MCP-1 and GM-CSF expression, cytokines and factors that are associated with GBM and poor prognosis.
Positive_regulation (increases) of Gene_expression (expression) of IL6 in GBM associated with glioblastoma and cytokine
17) Confidence 0.54 Published 2008 Journal J Transl Med Section Abstract Doc Link PMC2645376 Disease Relevance 1.74 Pain Relevance 0.12
With RA plasma concentrations ranging from 0% to 20% used alone (n = 4), IL-6 production by synoviocytes increased in a dose-dependent manner (Fig. 2a).
Positive_regulation (increased) of Gene_expression (production) of IL-6 in plasma associated with rheumatoid arthritis
18) Confidence 0.53 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064892 Disease Relevance 0.30 Pain Relevance 0.31
at 5 ng/ml increased IL-6 production to 43.5 ng/ml.
Positive_regulation (increased) of Gene_expression (production) of IL-6
19) Confidence 0.53 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064892 Disease Relevance 0.26 Pain Relevance 0.37
By using the B9 cell bioassay, it was found that injection of pristane caused a marked and prolonged elevation of interleukin-6 (IL-6) levels in the peritoneal cavities of the mice.
Positive_regulation (elevation) of Gene_expression (levels) of IL-6 in cavities
20) Confidence 0.50 Published 1992 Journal Blood Section Abstract Doc Link 1611085 Disease Relevance 0.36 Pain Relevance 0.13

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