INT9658

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Context Info
Confidence 0.59
First Reported 1992
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 110
Total Number 112
Disease Relevance 66.29
Pain Relevance 32.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) extracellular region (Il6)
Anatomy Link Frequency
macrophage 15
brain 10
retina 8
plasma 6
monocyte 6
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1669 100.00 Very High Very High Very High
cytokine 1227 100.00 Very High Very High Very High
rheumatoid arthritis 566 100.00 Very High Very High Very High
Arthritis 496 100.00 Very High Very High Very High
chemokine 181 100.00 Very High Very High Very High
qutenza 24 99.98 Very High Very High Very High
aspirin 18 99.98 Very High Very High Very High
Dextromethorphan 14 99.84 Very High Very High Very High
cINOD 68 99.72 Very High Very High Very High
Opioid 156 99.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1826 100.00 Very High Very High Very High
Rheumatoid Arthritis 571 100.00 Very High Very High Very High
Arthritis 561 100.00 Very High Very High Very High
Cancer 554 100.00 Very High Very High Very High
Adhesions 150 100.00 Very High Very High Very High
Sepsis 134 100.00 Very High Very High Very High
Necrosis 108 100.00 Very High Very High Very High
Neurodegenerative Disease 75 99.96 Very High Very High Very High
Targeted Disruption 149 99.78 Very High Very High Very High
Hypoxia 359 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of compounds A, B and C on leukocyte recruitment was paralleled by a significant inhibition of interleukin-6 and prostaglandin E(2)production in the exudate, similarly to indomethacin, and by a partial reduction of vascular permeability.
Negative_regulation (inhibition) of Gene_expression (production) of interleukin-6 in leukocyte
1) Confidence 0.59 Published 2001 Journal Pharmacol. Res. Section Abstract Doc Link 11394936 Disease Relevance 0.28 Pain Relevance 0.24
1,5-Benzodiazepine tricyclic derivatives exerting anti-inflammatory effects in mice by inhibiting interleukin-6 and prostaglandinE(2)production.
Negative_regulation (inhibiting) of Gene_expression (production) of interleukin-6 associated with inflammation and analgesic
2) Confidence 0.59 Published 2001 Journal Pharmacol. Res. Section Title Doc Link 11394936 Disease Relevance 0.50 Pain Relevance 0.43
Anti-TNF antibodies inhibited LPS-induced IL-6 production in three different models: IL-6 production by mouse peritoneal macrophages in vitro; serum IL-6 levels induced by intraperitoneal LPS; and brain IL-6 levels induced by an intracerebroventricular injection of LPS.
Negative_regulation (inhibited) of Gene_expression (production) of IL-6 in brain associated with intracerebroventricular
3) Confidence 0.55 Published 2000 Journal Cytokine Section Abstract Doc Link 10930297 Disease Relevance 0 Pain Relevance 0.05
Thus, attenuation of leukocyte recruitment by EPA may result in the decreased production levels of IL-6 and MCP-1 in the retina and choroid.
Negative_regulation (decreased) of Gene_expression (production) of IL-6 in retina
4) Confidence 0.47 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 1.14 Pain Relevance 0.41
Capsaicin inhibited the expressions of IL-6 and MCP-1 mRNAs and protein release from the adipose tissues and adipocytes of obese mice, whereas it enhanced the expression of the adiponectin gene and protein.
Negative_regulation (inhibited) of Gene_expression (expressions) of IL-6 in adipocytes associated with qutenza and obesity
5) Confidence 0.45 Published 2007 Journal FEBS Lett. Section Abstract Doc Link 17719033 Disease Relevance 1.22 Pain Relevance 0.65
All plasma samples from these patients inhibited the IL-6 production usually induced by TNF-?.
Negative_regulation (inhibited) of Gene_expression (production) of IL-6 in plasma
6) Confidence 0.45 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064892 Disease Relevance 0.24 Pain Relevance 0.24
RESULTS: In bone marrow-derived mast cells (BMMC), we found that heat shock and a number of NSAIDs induced heat shock protein 70 (HSP70), which was closely paralleled with inhibition of IL-6 and TNF-alpha production.
Negative_regulation (inhibition) of Gene_expression (production) of IL-6 in BMMC
7) Confidence 0.44 Published 2006 Journal Exp. Hematol. Section Body Doc Link 16569588 Disease Relevance 0.08 Pain Relevance 0
Both IL-6 and prostaglandin E2 production were inhibited by addition of indomethacin to macrophage cultures in vitro.
Negative_regulation (inhibited) of Gene_expression (production) of IL-6 in macrophage
8) Confidence 0.43 Published 1992 Journal Blood Section Abstract Doc Link 1611085 Disease Relevance 0.41 Pain Relevance 0.17
Chronic administration of the nonsteroidal anti-inflammatory drug indomethacin decreased the levels of IL-6 by 75% to 80%.
Negative_regulation (decreased) of Gene_expression (levels) of IL-6 associated with inflammation and cinod
9) Confidence 0.43 Published 1992 Journal Blood Section Abstract Doc Link 1611085 Disease Relevance 0.53 Pain Relevance 0.23
To analyze the possible correlation between the number of PV-interneurons in the old brain and cognitive ability, we subjected old animals to a series of simple memory tasks and compared their performance to that of similar age animals deficient in IL-6 production.
Negative_regulation (deficient) of Gene_expression (production) of IL-6 in brain associated with cognitive disorder
10) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.18 Pain Relevance 0.07
Also, PGHB reduced the carrageenan-induced paw edema at 3h after oral administration, and suppressed the production of serum IL-6 in CIA mice.
Negative_regulation (suppressed) of Gene_expression (production) of IL-6 in paw associated with pressure and volume under development
11) Confidence 0.43 Published 2008 Journal Food Chem. Toxicol. Section Abstract Doc Link 18930781 Disease Relevance 0.35 Pain Relevance 0.26
Lung immunohistochemical labeling of IL-6 and macrophages
Negative_regulation (labeling) of Gene_expression (immunohistochemical) of IL-6 in macrophages
12) Confidence 0.43 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.07 Pain Relevance 0
We interpreted the stimulation induced by sIL-6R alone as an autocrine effect of IL-6 produced by PA-SMCs, an observation also made by others using SMCs from the human aorta [35].
Negative_regulation (effect) of Gene_expression (produced) of IL-6 in aorta
13) Confidence 0.43 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.37 Pain Relevance 0.06
IL-6 protein expression was assessed in homogenates of total lungs from IL-6+/+ mice after exposure to 24 hours, 1 week, or 2 weeks of hypoxia and in normoxia.
Negative_regulation (assessed) of Gene_expression (expression) of IL-6 protein in lungs associated with hypoxia
14) Confidence 0.43 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.10 Pain Relevance 0
Thus, exposure to hypoxia leads to a transient rise in IL-6 expression, which does not mimic the sustained IL-6 elevation seen in patients with PH or COPD.
Negative_regulation (rise) of Gene_expression (expression) of IL-6 associated with pulmonary disease, primary pulmonary hypertension and hypoxia
15) Confidence 0.43 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 1.35 Pain Relevance 0
Pretreatment with U50,488 significantly reduced LPS-stimulated interleukin-6 (IL-6) production as measured by ELISA.
Negative_regulation (reduced) of Gene_expression (production) of interleukin-6
16) Confidence 0.43 Published 2006 Journal Int. Immunopharmacol. Section Abstract Doc Link 16644488 Disease Relevance 0.26 Pain Relevance 0.79
Reduction of lipopolysaccharide-induced interleukin-6 production by the kappa opioid U50,488 in a mouse monocyte-like cell line.
Negative_regulation (Reduction) of Gene_expression (production) of interleukin-6 in monocyte associated with opioid
17) Confidence 0.43 Published 2006 Journal Int. Immunopharmacol. Section Title Doc Link 16644488 Disease Relevance 0.26 Pain Relevance 0.68
Pretreatment with U50,488 significantly reduced LPS-stimulated interleukin-6 (IL-6) production as measured by ELISA.
Negative_regulation (reduced) of Gene_expression (production) of IL-6
18) Confidence 0.43 Published 2006 Journal Int. Immunopharmacol. Section Abstract Doc Link 16644488 Disease Relevance 0.26 Pain Relevance 0.79
B activation, expression of these two cytokines, measured by RT-qPCR, was not statistically different between old wild-type and old IL-6-/- mice (data not shown) suggesting that the specific loss of IL-6 expression, not changes in these other cytokines, was responsible for decreased nuclear NF?
Negative_regulation (loss) of Gene_expression (expression) of IL-6 associated with cytokine
19) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.20 Pain Relevance 0.14
These data indicate that IL-6 and TNF production are differently susceptible to glucocorticoids, and that prostaglandins can physiologically provide a negative feedback regulation of IL-6 and TNF synthesis.
Negative_regulation (regulation) of Gene_expression (synthesis) of IL-6
20) Confidence 0.43 Published 1992 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 1428359 Disease Relevance 0.37 Pain Relevance 0.31

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