INT9659

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Context Info
Confidence 0.78
First Reported 1990
Last Reported 2011
Negated 18
Speculated 36
Reported most in Body
Documents 991
Total Number 1030
Disease Relevance 715.11
Pain Relevance 265.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) extracellular region (Il6)
Anatomy Link Frequency
macrophages 40
plasma 37
lung 21
monocytes 20
brain 17
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 16916 100.00 Very High Very High Very High
cytokine 14238 100.00 Very High Very High Very High
Arthritis 3320 100.00 Very High Very High Very High
chemokine 2060 100.00 Very High Very High Very High
Inflammatory mediators 744 100.00 Very High Very High Very High
Pain 592 100.00 Very High Very High Very High
metalloproteinase 587 100.00 Very High Very High Very High
Nerve growth factor 88 100.00 Very High Very High Very High
COX2 32 100.00 Very High Very High Very High
anakinra 25 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 19562 100.00 Very High Very High Very High
Cancer 5753 100.00 Very High Very High Very High
Infection 4428 100.00 Very High Very High Very High
Arthritis 3402 100.00 Very High Very High Very High
Hypoxia 3252 100.00 Very High Very High Very High
Targeted Disruption 2602 100.00 Very High Very High Very High
Necrosis 1535 100.00 Very High Very High Very High
Adhesions 1059 100.00 Very High Very High Very High
Sepsis 1016 100.00 Very High Very High Very High
Alzheimer's Dementia 609 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By using the B9 cell bioassay, it was found that injection of pristane caused a marked and prolonged elevation of interleukin-6 (IL-6) levels in the peritoneal cavities of the mice.
Gene_expression (levels) of IL-6 in cavities
1) Confidence 0.78 Published 1992 Journal Blood Section Abstract Doc Link 1611085 Disease Relevance 0.36 Pain Relevance 0.13
By using the B9 cell bioassay, it was found that injection of pristane caused a marked and prolonged elevation of interleukin-6 (IL-6) levels in the peritoneal cavities of the mice.
Gene_expression (levels) of interleukin-6 in cavities
2) Confidence 0.78 Published 1992 Journal Blood Section Abstract Doc Link 1611085 Disease Relevance 0.36 Pain Relevance 0.13
These data document the in vivo production of cutaneous IL-6, a distinct inflammatory biomarker, in two different HD exposure models.
Gene_expression (production) of IL-6 associated with inflammation
3) Confidence 0.78 Published 2000 Journal J Appl Toxicol Section Abstract Doc Link 11428647 Disease Relevance 0.72 Pain Relevance 0.42
The expression of IL-6 was increased by vincristine administration and was co-localized in the invading macrophage.
Gene_expression (expression) of IL-6 in macrophage associated with vincristine
4) Confidence 0.78 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18652822 Disease Relevance 0.81 Pain Relevance 1.24
We found marked increases in hypoxic lung expression of both IL-6 receptor and gp 130, which lasted up to 14 days.
Gene_expression (expression) of IL-6 in lung associated with hypoxia
5) Confidence 0.78 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 1.41 Pain Relevance 0
IL-6 protein expression was assessed in homogenates of total lungs from IL-6+/+ mice after exposure to 24 hours, 1 week, or 2 weeks of hypoxia and in normoxia.
Gene_expression (expression) of IL-6 protein in lungs associated with hypoxia
6) Confidence 0.78 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.10 Pain Relevance 0
Thus, exposure to chronic hypoxia is associated not only with a large increase in lung IL-6 levels, but also with increased expression of the IL-6 receptor.
Gene_expression (expression) of IL-6 in lung associated with hypoxia
7) Confidence 0.78 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 1.57 Pain Relevance 0
We found that IL-6 was expressed by both P-ECs and PA-SMCs but that the amount of IL-6 originating from PA-SMCs was far greater than the amount from P-ECs.
Gene_expression (expressed) of IL-6
8) Confidence 0.78 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 1.23 Pain Relevance 0.08
This polymorphism influences the levels of circulating IL-6, suggesting a causal role for high circulating IL-6 levels in the pathogenesis of PH in patients with COPD.
Gene_expression (levels) of IL-6 associated with pulmonary disease and primary pulmonary hypertension
9) Confidence 0.78 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 1.70 Pain Relevance 0.32
In lung vessels, IL-6 was mainly expressed by SMCs, as shown by immunohistochemical examination of lungs from hypoxic wild-type mice, as well as by studies of cultured cells.
Gene_expression (expressed) of IL-6 in vessels associated with hypoxia
10) Confidence 0.78 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 1.34 Pain Relevance 0.18
In these studies, hypoxia induced IL-6 expression via enhanced transcription driven by the nuclear factor IL-6 site in the IL-6 promoter.
Gene_expression (expression) of IL-6 associated with hypoxia
11) Confidence 0.78 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 1.38 Pain Relevance 0
Short-term exposure of PA-SMCs to hypoxia also markedly stimulated IL-6 expression, suggesting that PA-SMCs may represent a major source of IL-6 in the lung, especially during the development of hypoxic PH.
Gene_expression (expression) of IL-6 in lung associated with primary pulmonary hypertension and hypoxia
12) Confidence 0.78 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 1.36 Pain Relevance 0.03
Cultures (5ยท104 cells/well) of P-ECs and of PA-SMCs were prepared, and IL-6 levels in the culture cell lysates were measured using an ELISA (R&D Systems, Lille, France).
Gene_expression (levels) of IL-6
13) Confidence 0.78 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0 Pain Relevance 0
Thus, exposure to hypoxia leads to a transient rise in IL-6 expression, which does not mimic the sustained IL-6 elevation seen in patients with PH or COPD.
Gene_expression (expression) of IL-6 associated with pulmonary disease, primary pulmonary hypertension and hypoxia
14) Confidence 0.78 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 1.34 Pain Relevance 0
The rise in IL-6 protein lasted up to 7 days, and PH developed within 2 weeks in hypoxic mice, allowing us to evaluate whether changes in IL-6 expression affected PH development in our model.
Gene_expression (expression) of IL-6 associated with primary pulmonary hypertension and hypoxia
15) Confidence 0.78 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 1.34 Pain Relevance 0
Moreover, IL-6 expression seems increased in many types of human and experimental PH, including monocrotaline-induced PH in rats, suggesting that IL-6 may modulate the extent of PH despite the absence of a hypoxic pulmonary vasoconstrictor component.
Gene_expression (expression) of IL-6 associated with primary pulmonary hypertension and hypoxia
16) Confidence 0.78 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 1.39 Pain Relevance 0.27
IL-6 receptors are expressed not only by inflammatory cells, but also by constitutive vessel-wall cells.
Gene_expression (expressed) of IL-6 associated with inflammation
17) Confidence 0.78 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.86 Pain Relevance 0.28
Short-term exposure of PA-SMCs to hypoxia also markedly stimulated IL-6 expression, suggesting that PA-SMCs may represent a major source of IL-6 in the lung, especially during the development of hypoxic PH.
Gene_expression (source) of IL-6 in lung associated with primary pulmonary hypertension and hypoxia
18) Confidence 0.78 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 1.37 Pain Relevance 0
We interpreted the stimulation induced by sIL-6R alone as an autocrine effect of IL-6 produced by PA-SMCs, an observation also made by others using SMCs from the human aorta [35].
Gene_expression (produced) of IL-6 in aorta
19) Confidence 0.78 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.37 Pain Relevance 0.06
The effect of compounds A, B and C on leukocyte recruitment was paralleled by a significant inhibition of interleukin-6 and prostaglandin E(2)production in the exudate, similarly to indomethacin, and by a partial reduction of vascular permeability.
Gene_expression (production) of interleukin-6 in leukocyte
20) Confidence 0.78 Published 2001 Journal Pharmacol. Res. Section Abstract Doc Link 11394936 Disease Relevance 0.27 Pain Relevance 0.24

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