INT96622

Context Info Confidence 0.81 First Reported 2001 Last Reported 2011 Negated 1 Speculated 4 Reported most in Abstract Documents 110 Total Number 116 Disease Relevance 59.82 Pain Relevance 63.25

cytosol (Trpv1) transport (Trpv1) plasma membrane (Trpv1) transmembrane transport (Trpv1) lipid metabolic process (Trpv1)

Anatomy Link Frequency neurons 14 nerve 7 nociceptors 4 plasma 3 IB4 3 Trpv1 (Mus musculus)

Pain Link Frequency Relevance Heat qutenza 2234 100.00 Inflammation 1226 100.00 agonist 480 100.00 nociceptor 421 100.00 substance P 260 100.00 bradykinin 186 100.00 Calcitonin gene-related peptide 186 100.00 calcitonin gene related peptide 155 100.00 primary afferent fibers 6 100.00 Nerve growth factor 186 99.98

Disease Link Frequency Relevance Heat INFLAMMATION 1327 100.00 Osteogenic Sarcomas 22 100.00 Attention Deficit Hyperactivity Disorder 12 100.00 Targeted Disruption 445 99.96 Hypersensitivity 91 99.92 Pulmonary Disease 12 99.92 Ganglion Cysts 940 99.84 Injury 145 99.82 Diabetes Mellitus 440 99.74 Coronary Artery Disease 31 99.72

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Based on the painful effects of exposure to capsaicin, TRPV1 (transient receptor potential vanilloid subfamily member 1) localization is most readily associated with peripheral sensory neurons, however, TRPV1 is now known to be expressed, albeit at lower levels, in the spinal cord, brain and a wide-range of non-neuronal cells.

Localization (localization) of TRPV1 in sensory neurons associated with pain, qutenza and spinal cord

1) Confidence 0.81 Published 2008 Journal Curr. Pharm. Des. Section Abstract Doc Link 18220816 Disease Relevance 0 Pain Relevance 0.25

Localization of TRPV1 and contractile effect of capsaicin in mouse large intestine: high abundance and sensitivity in rectum and distal colon.

Localization (Localization) of TRPV1 in large intestine associated with qutenza

2) Confidence 0.80 Published 2009 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 19497956 Disease Relevance 0 Pain Relevance 0.40

A step increase of temperature from 22 to 40 degrees C caused a TRPV1-independent CGRP release that was doubled by bradykinin in wild-types but not TRPV1(-/-).

Localization (release) of TRPV1 associated with bradykinin and calcitonin gene-related peptide

3) Confidence 0.80 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19473241 Disease Relevance 0.44 Pain Relevance 0.68

Colocalization study showed that the percentages of colocalization of TRPV1 with neurofilament 200 kD (NF200) and calcitonin gene-related peptide (CGRP) but not isolectin B4 (IB4) among DRG neurons in mice with osteosarcoma implantation were increased compared with those in sham mice (from 0.8+/-0.1% to 2.1+/-0.3% for TRPV1 and NF200 and from 21.1+/-1.3% to 26.5+/-0.2% for TRPV1 and CGRP).

Localization (colocalization) of TRPV1 in IB4 associated with osteogenic sarcomas and calcitonin gene-related peptide

4) Confidence 0.80 Published 2007 Journal Neuroscience Section Abstract Doc Link 17656027 Disease Relevance 1.13 Pain Relevance 0.59

In uninjured murine fibers innervating hairy skin, TRPV1 is localized specifically in a subpopulation of C-fiber nociceptors that respond to heat (CH-fibers) but not mechanical or cold stimuli [10,11].

Localization (localized) of TRPV1 in nociceptors associated with c fibre and nociceptor

5) Confidence 0.80 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949725 Disease Relevance 0.75 Pain Relevance 0.87

The localization of TRPV1-containing astrocytes apposed to nociceptive C-terminals suggests that they may be involved in the control of pain transmission.

Localization (localization) of TRPV1-containing in astrocytes associated with nociception and pain

6) Confidence 0.80 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15036590 Disease Relevance 0.52 Pain Relevance 0.13

However, endogenous ligands excite TRPV1 receptors localized on central nociceptive terminals and interneurons.

Localization (localized) of TRPV1 in interneurons associated with nociception

7) Confidence 0.80 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15036590 Disease Relevance 0.41 Pain Relevance 0.04

TRPV1 mediated CGRP release could play a role in increasing blood supply to malignancies of the GI tract; the beneficial effect of COX inhibitors in this regard may arise from their ability to reduce TRPV1-mediated CGRP release and inhibition of PG-mediated angiogenesis.

Localization (release) of TRPV1 in blood associated with calcitonin gene related peptide

8) Confidence 0.80 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.49 Pain Relevance 0.99

Phosphorylation not only sensitizes the receptor and augments its response, but also promotes translocation of TRPV1 from the cytosol to the plasma membrane [124, 167, 190].

Localization (translocation) of TRPV1 in plasma

9) Confidence 0.80 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.29 Pain Relevance 0.45

Analysis of the lateral (LA), basolateral (BL) and central nucleus (CE) of the amygdala revealed that TRPV1 protein mainly localizes to neuronal cells (Fig. 1A–C).

Localization (localizes) of TRPV1 in lateral associated with amygdala

10) Confidence 0.79 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0 Pain Relevance 1.03

There is morphological evidence for stimulated vesicular exocytosis and for capsaicin receptor, transient receptor potential vanilloid type-1 (TRPV1, formerly VR1) translocation in the axolemma of unmyelinated nerve fibres.

Localization (translocation) of TRPV1 in nerve associated with qutenza and unmyelinated

11) Confidence 0.78 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17610576 Disease Relevance 0 Pain Relevance 0.52

There is morphological evidence for stimulated vesicular exocytosis and for capsaicin receptor, transient receptor potential vanilloid type-1 (TRPV1, formerly VR1) translocation in the axolemma of unmyelinated nerve fibres.

Localization (translocation) of VR1 in nerve associated with qutenza and unmyelinated

12) Confidence 0.78 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17610576 Disease Relevance 0 Pain Relevance 0.52

Transient potential vanilloid 1 (TRPV1) receptor is an ion channel receptor primarily localized on sensory nerves and activated by specific stimuli to initiate and amplify pain and inflammation, as typified by murine models of scald and arthritis.

Localization (localized) of TRPV1 in sensory nerves associated with pain, inflammation and arthritis

13) Confidence 0.75 Published 2007 Journal FASEB J. Section Abstract Doc Link 17601984 Disease Relevance 0.97 Pain Relevance 0.23

Therefore, as diabetes progresses, modulation of TRPV1 has the potential to contribute to many complications such as CNS, cardiovascular, respiratory and urinary disturbances.

Localization (modulation) of TRPV1 in respiratory associated with diabetes mellitus

14) Confidence 0.75 Published 2008 Journal Mol Pain Section Body Doc Link PMC2275252 Disease Relevance 0.30 Pain Relevance 0.08

Sensitization of TRPV1 by phosphorylation is mediated by numerous factors including, prostaglandins [17,18], bradykinin [19-21], glutamate [22], serotonin [23], histamine [24], ATP [25-27], trypsin [28,29] and nerve growth factor (NGF) [14,30].

Localization (Sensitization) of TRPV1 in nerve associated with glutamate, nerve growth factor, serotonin and bradykinin

15) Confidence 0.75 Published 2008 Journal Mol Pain Section Body Doc Link PMC2275252 Disease Relevance 1.20 Pain Relevance 0.91

TRPV1 and TRPV2 were often co-localized with substance P, while the co-localization of substance P and TRPV3 was rare and TRPV4 was not co-localized with substance P.

Localization (co-localized) of TRPV1

16) Confidence 0.75 Published 2008 Journal Acta Otolaryngol. Section Body Doc Link 18568506 Disease Relevance 0.25 Pain Relevance 0

A step increase of temperature from 22 to 40 degrees C caused a TRPV1-independent CGRP release that was doubled by bradykinin in wild-types but not TRPV1(-/-).

Localization (release) of TRPV1 associated with bradykinin and calcitonin gene-related peptide

17) Confidence 0.75 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19473241 Disease Relevance 0.44 Pain Relevance 0.68

Colocalization study showed that the percentages of colocalization of TRPV1 with neurofilament 200 kD (NF200) and calcitonin gene-related peptide (CGRP) but not isolectin B4 (IB4) among DRG neurons in mice with osteosarcoma implantation were increased compared with those in sham mice (from 0.8+/-0.1% to 2.1+/-0.3% for TRPV1 and NF200 and from 21.1+/-1.3% to 26.5+/-0.2% for TRPV1 and CGRP).

Localization (colocalization) of TRPV1 in IB4 associated with osteogenic sarcomas and calcitonin gene-related peptide

18) Confidence 0.75 Published 2007 Journal Neuroscience Section Abstract Doc Link 17656027 Disease Relevance 1.18 Pain Relevance 0.64

Colocalization study showed that the percentages of colocalization of TRPV1 with neurofilament 200 kD (NF200) and calcitonin gene-related peptide (CGRP) but not isolectin B4 (IB4) among DRG neurons in mice with osteosarcoma implantation were increased compared with those in sham mice (from 0.8+/-0.1% to 2.1+/-0.3% for TRPV1 and NF200 and from 21.1+/-1.3% to 26.5+/-0.2% for TRPV1 and CGRP).

Localization (colocalization) of TRPV1 in IB4 associated with osteogenic sarcomas and calcitonin gene-related peptide

19) Confidence 0.75 Published 2007 Journal Neuroscience Section Abstract Doc Link 17656027 Disease Relevance 1.17 Pain Relevance 0.63

TRPV1-independent heat sensitization of CPM fibers

Localization (sensitization) of TRPV1

20) Confidence 0.75 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949725 Disease Relevance 0.85 Pain Relevance 0.63

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