INT96622
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Based on the painful effects of exposure to capsaicin, TRPV1 (transient receptor potential vanilloid subfamily member 1) localization is most readily associated with peripheral sensory neurons, however, TRPV1 is now known to be expressed, albeit at lower levels, in the spinal cord, brain and a wide-range of non-neuronal cells. | |||||||||||||||
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Localization of TRPV1 and contractile effect of capsaicin in mouse large intestine: high abundance and sensitivity in rectum and distal colon. | |||||||||||||||
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A step increase of temperature from 22 to 40 degrees C caused a TRPV1-independent CGRP release that was doubled by bradykinin in wild-types but not TRPV1(-/-). | |||||||||||||||
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Colocalization study showed that the percentages of colocalization of TRPV1 with neurofilament 200 kD (NF200) and calcitonin gene-related peptide (CGRP) but not isolectin B4 (IB4) among DRG neurons in mice with osteosarcoma implantation were increased compared with those in sham mice (from 0.8+/-0.1% to 2.1+/-0.3% for TRPV1 and NF200 and from 21.1+/-1.3% to 26.5+/-0.2% for TRPV1 and CGRP). | |||||||||||||||
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In uninjured murine fibers innervating hairy skin, TRPV1 is localized specifically in a subpopulation of C-fiber nociceptors that respond to heat (CH-fibers) but not mechanical or cold stimuli [10,11]. | |||||||||||||||
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The localization of TRPV1-containing astrocytes apposed to nociceptive C-terminals suggests that they may be involved in the control of pain transmission. | |||||||||||||||
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However, endogenous ligands excite TRPV1 receptors localized on central nociceptive terminals and interneurons. | |||||||||||||||
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TRPV1 mediated CGRP release could play a role in increasing blood supply to malignancies of the GI tract; the beneficial effect of COX inhibitors in this regard may arise from their ability to reduce TRPV1-mediated CGRP release and inhibition of PG-mediated angiogenesis. | |||||||||||||||
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Phosphorylation not only sensitizes the receptor and augments its response, but also promotes translocation of TRPV1 from the cytosol to the plasma membrane [124, 167, 190]. | |||||||||||||||
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Analysis of the lateral (LA), basolateral (BL) and central nucleus (CE) of the amygdala revealed that TRPV1 protein mainly localizes to neuronal cells (Fig. 1AC). | |||||||||||||||
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There is morphological evidence for stimulated vesicular exocytosis and for capsaicin receptor, transient receptor potential vanilloid type-1 (TRPV1, formerly VR1) translocation in the axolemma of unmyelinated nerve fibres. | |||||||||||||||
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There is morphological evidence for stimulated vesicular exocytosis and for capsaicin receptor, transient receptor potential vanilloid type-1 (TRPV1, formerly VR1) translocation in the axolemma of unmyelinated nerve fibres. | |||||||||||||||
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Transient potential vanilloid 1 (TRPV1) receptor is an ion channel receptor primarily localized on sensory nerves and activated by specific stimuli to initiate and amplify pain and inflammation, as typified by murine models of scald and arthritis. | |||||||||||||||
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Therefore, as diabetes progresses, modulation of TRPV1 has the potential to contribute to many complications such as CNS, cardiovascular, respiratory and urinary disturbances.
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Sensitization of TRPV1 by phosphorylation is mediated by numerous factors including, prostaglandins [17,18], bradykinin [19-21], glutamate [22], serotonin [23], histamine [24], ATP [25-27], trypsin [28,29] and nerve growth factor (NGF) [14,30]. | |||||||||||||||
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TRPV1 and TRPV2 were often co-localized with substance P, while the co-localization of substance P and TRPV3 was rare and TRPV4 was not co-localized with substance P.
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A step increase of temperature from 22 to 40 degrees C caused a TRPV1-independent CGRP release that was doubled by bradykinin in wild-types but not TRPV1(-/-). | |||||||||||||||
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Colocalization study showed that the percentages of colocalization of TRPV1 with neurofilament 200 kD (NF200) and calcitonin gene-related peptide (CGRP) but not isolectin B4 (IB4) among DRG neurons in mice with osteosarcoma implantation were increased compared with those in sham mice (from 0.8+/-0.1% to 2.1+/-0.3% for TRPV1 and NF200 and from 21.1+/-1.3% to 26.5+/-0.2% for TRPV1 and CGRP). | |||||||||||||||
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Colocalization study showed that the percentages of colocalization of TRPV1 with neurofilament 200 kD (NF200) and calcitonin gene-related peptide (CGRP) but not isolectin B4 (IB4) among DRG neurons in mice with osteosarcoma implantation were increased compared with those in sham mice (from 0.8+/-0.1% to 2.1+/-0.3% for TRPV1 and NF200 and from 21.1+/-1.3% to 26.5+/-0.2% for TRPV1 and CGRP). | |||||||||||||||
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TRPV1-independent heat sensitization of CPM fibers | |||||||||||||||
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General Comments
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