INT96624

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Context Info
Confidence 0.70
First Reported 2001
Last Reported 2010
Negated 6
Speculated 2
Reported most in Abstract
Documents 62
Total Number 64
Disease Relevance 20.50
Pain Relevance 34.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) plasma membrane (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
DRG 7
neurons 6
sensory nerves 6
sensory neurons 4
knee joints 2
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 637 100.00 Very High Very High Very High
B1 receptor 194 100.00 Very High Very High Very High
bradykinin 167 100.00 Very High Very High Very High
Pain 149 100.00 Very High Very High Very High
allodynia 78 100.00 Very High Very High Very High
Calcitonin gene-related peptide 49 100.00 Very High Very High Very High
Thermal hyperalgesia 45 100.00 Very High Very High Very High
Glutamate 27 100.00 Very High Very High Very High
vanilloid receptor subtype 1 5 100.00 Very High Very High Very High
GABAergic 4 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 187 100.00 Very High Very High Very High
Hyperalgesia 135 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 10 100.00 Very High Very High Very High
Tinnitus 8 100.00 Very High Very High Very High
Heart Rate Under Development 5 100.00 Very High Very High Very High
Nociception 85 99.84 Very High Very High Very High
Diabetes Mellitus 157 99.78 Very High Very High Very High
Cancer Pain 5 99.76 Very High Very High Very High
Hypothermia 9 99.66 Very High Very High Very High
Ganglion Cysts 569 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compared with the controls, VR1 protein was decreased in DRG whole-cell homogenates from diabetic rats, but increased levels of VR1 protein were observed on plasma membranes.
Positive_regulation (increased) of Positive_regulation (levels) of VR1 in DRG associated with dorsal root ganglion and diabetes mellitus
1) Confidence 0.70 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15513920 Disease Relevance 1.84 Pain Relevance 1.30
Increased phosphorylation levels of VR1 were also observed in DRG neurons from diabetic rats.
Positive_regulation (Increased) of Positive_regulation (levels) of VR1 in neurons associated with dorsal root ganglion and diabetes mellitus
2) Confidence 0.70 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15513920 Disease Relevance 1.75 Pain Relevance 1.27
PERSPECTIVE: We describe a cancer pain model that induced marked mechanical allodynia, thermal hyperalgesia, signs of spontaneous nocifensive behavior, and upregulation of TRPV1.
Positive_regulation (induced) of Positive_regulation (upregulation) of TRPV1 associated with allodynia, cancer pain and thermal hyperalgesia
3) Confidence 0.70 Published 2008 Journal J Pain Section Abstract Doc Link 18455478 Disease Relevance 1.20 Pain Relevance 1.43
This suggests that salicylate could induce tinnitus through activation of TRPV1 in the rat auditory pathway.
Positive_regulation (induce) of Positive_regulation (activation) of TRPV1 associated with tinnitus
4) Confidence 0.69 Published 2010 Journal Neuroscience Section Abstract Doc Link 19958810 Disease Relevance 0.51 Pain Relevance 0.10
These results with mutant analysis suggest that PKC phosphorylation does not play a critical role in the induction of TRPV1 activation by 100 ?
Neg (not) Positive_regulation (play) of Positive_regulation (induction) of TRPV1 associated with kinase c
5) Confidence 0.69 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576176 Disease Relevance 0 Pain Relevance 1.00
Activation of VR1 potently enhances glutamate release onto GABAergic terminals, facilitating GABA release.
Positive_regulation (facilitating) of Positive_regulation (Activation) of VR1 associated with gaba, glutamate and gabaergic
6) Confidence 0.68 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16988037 Disease Relevance 0 Pain Relevance 0.72
Putative endogenous activators (anandamide and metabolites of arachidonic acid) are weak activators of VR1 compared to capsaicin and RTX, and the concentrations of the physiological condition of those activators are not sufficient to induce significant activation of VR1.
Neg (not) Positive_regulation (sufficient) of Positive_regulation (activation) of VR1 associated with qutenza
7) Confidence 0.68 Published 2005 Journal Arch. Pharm. Res. Section Abstract Doc Link 15918513 Disease Relevance 0 Pain Relevance 0.19
Previous investigations have demonstrated that the hypotensive effect of rutaecarpine (Rut) is associated to stimulation of CGRP synthesis and release via activation of the vanilloid receptor subtype 1 (VR1) in the phenol-induced hypertensive rat.
Positive_regulation (stimulation) of Positive_regulation (activation) of VR1 associated with vanilloid receptor subtype 1, hypertension, hypotension and calcitonin gene-related peptide
8) Confidence 0.62 Published 2007 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 18091582 Disease Relevance 0.52 Pain Relevance 0.49
However, very recent reports demonstrate that activation of VR1 by anandamide can be significantly enhanced by various regulatory factors, suggesting that this compound might act as an "endovanilloid" under certain conditions.
Positive_regulation (enhanced) of Positive_regulation (activation) of VR1
9) Confidence 0.60 Published 2001 Journal Trends Pharmacol. Sci. Section Abstract Doc Link 11431028 Disease Relevance 0 Pain Relevance 0.14
Constitutive simultaneous stimulation of both ERK and phosphatidylinositol 3-kinase is not sufficient for VR1 upregulation.
Neg (not) Positive_regulation (sufficient) of Positive_regulation (upregulation) of VR1
10) Confidence 0.59 Published 2003 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 12595244 Disease Relevance 0.24 Pain Relevance 0.17
The present data demonstrate that AM 404 evokes a significant hypothermia in rats that is dependent on TRPV1 receptor activation.
Positive_regulation (dependent) of Positive_regulation (activation) of TRPV1 receptor associated with hypothermia
11) Confidence 0.50 Published 2006 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 16647109 Disease Relevance 0.66 Pain Relevance 0.23
These results suggest that anandamide, through activating TRPV1, contributes to the development of hyperreflexia and hyperalgesia during cystitis.
Positive_regulation (contributes) of Positive_regulation (activating) of TRPV1 associated with hyperalgesia, cystitis and abnormal reflex
12) Confidence 0.50 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15601931 Disease Relevance 0.57 Pain Relevance 0.32
The vanilloid moiety of curcumin is considered important for activation of the transient receptor potential vanilloid 1 (TRPV1), which plays an important role in nociception.
Positive_regulation (important) of Positive_regulation (activation) of TRPV1 associated with nociception
13) Confidence 0.50 Published 2010 Journal J. Dent. Res. Section Abstract Doc Link 20040737 Disease Relevance 0.74 Pain Relevance 0.39
On the basis of these results, we conclude that increasing temperature within the normal physiological range can exert a direct stimulatory effect on pulmonary sensory neurons, and this effect is mediated through the activation of TRPV1, as well as other subtypes of TRPV channels.
Positive_regulation (mediated) of Positive_regulation (activation) of TRPV1 in sensory neurons
14) Confidence 0.50 Published 2006 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 16513770 Disease Relevance 0.05 Pain Relevance 0.04
VR1 receptor activation induces glutamate release and postsynaptic firing in the paraventricular nucleus.
Positive_regulation (induces) of Positive_regulation (activation) of VR1 receptor in nucleus associated with glutamate and qutenza
15) Confidence 0.50 Published 2004 Journal J. Neurophysiol. Section Title Doc Link 15115794 Disease Relevance 0 Pain Relevance 0.50
Together, the present results strongly suggest that the pharmacological actions of plant-derived sesquiterpenes polygodial and drimanial, seem to be partially mediated by activation of TRPV1.
Spec (partially) Positive_regulation (mediated) of Positive_regulation (activation) of TRPV1
16) Confidence 0.50 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16457780 Disease Relevance 0 Pain Relevance 0.43
Activation of TRPV1 in the VTA excites dopaminergic neurons and increases chemical- and noxious-induced dopamine release in the nucleus accumbens.
Positive_regulation (increases) of in nucleus accumbens Positive_regulation (Activation) of TRPV1 in dopaminergic neurons associated with nucleus accumbens, dopamine and qutenza
17) Confidence 0.50 Published 2005 Journal Neuropsychopharmacology Section Title Doc Link 15562294 Disease Relevance 0 Pain Relevance 1.08
Therefore, the analgesic properties of anandamide are likely to be mediated, at least in part, by VR1 activation in DRG cells in vivo.


Spec (likely) Positive_regulation (mediated) of Positive_regulation (activation) of VR1 in DRG
18) Confidence 0.50 Published 2002 Journal Br J Anaesth Section Body Doc Link 12453933 Disease Relevance 0 Pain Relevance 0
OBJECTIVE: To test the hypothesis that activation of the vanilloid receptor (VR1) by high salt intake prevents salt-induced increases in arterial pressure via stimulation of release of calcitonin gene-related peptide (CGRP) from sensory nerves.
Positive_regulation (increases) of Positive_regulation (activation) of vanilloid receptor in sensory nerves associated with calcitonin gene-related peptide
19) Confidence 0.50 Published 2003 Journal J. Hypertens. Section Abstract Doc Link 12872047 Disease Relevance 0 Pain Relevance 0.05
OBJECTIVE: To test the hypothesis that activation of the vanilloid receptor (VR1) by high salt intake prevents salt-induced increases in arterial pressure via stimulation of release of calcitonin gene-related peptide (CGRP) from sensory nerves.
Positive_regulation (increases) of Positive_regulation (activation) of VR1 in sensory nerves associated with calcitonin gene-related peptide
20) Confidence 0.50 Published 2003 Journal J. Hypertens. Section Abstract Doc Link 12872047 Disease Relevance 0 Pain Relevance 0.05

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