INT9663

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Context Info
Confidence 0.99
First Reported 1980
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 43
Total Number 43
Disease Relevance 0.67
Pain Relevance 16.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (PDYN) extracellular region (PDYN) plasma membrane (PDYN)
Anatomy Link Frequency
plasma 4
erythrocytes 2
striatum 2
mononuclear cells 2
brain 1
PDYN (Homo sapiens)
PDYN - A2L (1)
Pain Link Frequency Relevance Heat
Enkephalin 181 100.00 Very High Very High Very High
Dynorphin 5 99.84 Very High Very High Very High
dexamethasone 6 98.08 Very High Very High Very High
Endogenous opioid 4 94.96 High High
substance P 3 93.76 High High
Opioid 9 92.60 High High
Neuropeptide 4 88.40 High High
bradykinin 2 88.08 High High
cerebral cortex 1 85.56 High High
Bioavailability 1 79.20 Quite High
Disease Link Frequency Relevance Heat
Stress 2 99.52 Very High Very High Very High
Leukemia 1 96.82 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 95.92 Very High Very High Very High
Neurological Disease 1 88.28 High High
Disease 2 76.60 Quite High
Infection 3 69.28 Quite High
Headache 1 41.24 Quite Low
Viral Infection 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We showed that leucine-enkephalin is rapidly degraded by the cytosolic peptidases of the human erythrocyte, and we have elucidated the most probable pathway of degradation.
Protein_catabolism (degraded) of leucine-enkephalin in erythrocyte associated with enkephalin
1) Confidence 0.99 Published 1985 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 4062293 Disease Relevance 0 Pain Relevance 0.27
High resolution (400 MHz) 1H spin-echo NMR spectroscopy was used to monitor the degradation of leucine-enkephalin, and peptide fragments of it, by human erythrocytes and hemolysates.
Protein_catabolism (degradation) of leucine-enkephalin in erythrocytes associated with enkephalin
2) Confidence 0.99 Published 1985 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 4062293 Disease Relevance 0 Pain Relevance 0.27
The new pathway of degradation of Leu-enkephalin by carboxypeptidase that provides for approximately 6% of the total enkephalin-degrading activity was discovered.
Protein_catabolism (degradation) of Leu-enkephalin associated with enkephalin
3) Confidence 0.98 Published 2004 Journal Bioorg. Khim. Section Abstract Doc Link 15344652 Disease Relevance 0 Pain Relevance 0.59
Results obtained indicate that leu-enkephalin is partially degraded in the presence of soluble supernatants prepared from mononuclear cells.
Protein_catabolism (degraded) of leu-enkephalin in mononuclear cells associated with enkephalin
4) Confidence 0.95 Published 1993 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8375944 Disease Relevance 0 Pain Relevance 0.28
The release of soluble peptidases active in the degradation of leucine enkephalin by human peripheral blood mononuclear cells (PBMC), and the effect of stimulation of mononuclear cells on the release of these enzymes are reported.
Protein_catabolism (degradation) of leucine enkephalin in mononuclear cells associated with enkephalin
5) Confidence 0.95 Published 1993 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8375944 Disease Relevance 0 Pain Relevance 0.25
Hydrolysis of Leu-enkephalin and association to cells of the radioactive label carried by this peptide have been studied on the K562(S) erythroleukaemic cell subline.
Protein_catabolism (Hydrolysis) of Leu-enkephalin associated with enkephalin
6) Confidence 0.89 Published 1994 Journal Immunopharmacology Section Abstract Doc Link 8014025 Disease Relevance 0 Pain Relevance 0.37
The k(cat) values of the somatic isozyme for beta-neoendorphin1-7 were 2-fold higher than those for beta-neoendorphin1-9, indicating that beta-neoendorphin1-7 is more rapidly hydrolyzed than beta-neoendorphin1-9.
Protein_catabolism (hydrolyzed) of beta-neoendorphin1-9
7) Confidence 0.89 Published 1997 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9165097 Disease Relevance 0 Pain Relevance 0.16
The k(cat) values of the somatic isozyme for beta-neoendorphin1-7 were 2-fold higher than those for beta-neoendorphin1-9, indicating that beta-neoendorphin1-7 is more rapidly hydrolyzed than beta-neoendorphin1-9.
Protein_catabolism (hydrolyzed) of beta-neoendorphin1-9
8) Confidence 0.89 Published 1997 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9165097 Disease Relevance 0 Pain Relevance 0.16
The k(cat) values of the somatic isozyme for beta-neoendorphin1-7 were 2-fold higher than those for beta-neoendorphin1-9, indicating that beta-neoendorphin1-7 is more rapidly hydrolyzed than beta-neoendorphin1-9.
Protein_catabolism (hydrolyzed) of beta-neoendorphin1-7
9) Confidence 0.89 Published 1997 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9165097 Disease Relevance 0 Pain Relevance 0.16
In agreement with known data, the data obtained indicate that Leu-enkephalin is degraded by several enzymes, belonging to three classes: aminopeptidases, dipeptidylaminopeptidases, and dipeptidylcarboxypeptidases.
Protein_catabolism (degraded) of Leu-enkephalin associated with enkephalin
10) Confidence 0.88 Published 1997 Journal Peptides Section Abstract Doc Link 9213370 Disease Relevance 0 Pain Relevance 0.34
Optimum activity for the degradation of Leu-enkephalin was obtained at pH10.5 in the presence of 5mM-Mn++.
Protein_catabolism (degradation) of Leu-enkephalin associated with enkephalin
11) Confidence 0.86 Published 1991 Journal Neuropeptides Section Abstract Doc Link 1680222 Disease Relevance 0 Pain Relevance 0.57
A rapid procedure for the determination of Leu-enkephalin (Tyr-Gly-Gly-Phe-Leu) and its main metabolic degradation products (Tyr, Tyr-Gly-Gly and Tyr-Gly) by reversed-phase high-performance liquid chromatography was developed.
Protein_catabolism (degradation) of Leu-enkephalin associated with enkephalin
12) Confidence 0.85 Published 1983 Journal J. Chromatogr. Section Abstract Doc Link 6841525 Disease Relevance 0 Pain Relevance 0.24
An unexpectedly high percentage of Tyr-Gly production is observed after enzymatic degradation of Leu-enkephalin by a solubilized enzyme preparation of calf-brain striatum.
Protein_catabolism (degradation) of Leu-enkephalin in striatum associated with enkephalin
13) Confidence 0.85 Published 1983 Journal J. Chromatogr. Section Abstract Doc Link 6841525 Disease Relevance 0 Pain Relevance 0.26
Determination of Leu-enkephalin degradation by a soluble enzyme preparation from calf-brain striatum using reversed-phase high-performance liquid chromatography.
Protein_catabolism (degradation) of Leu-enkephalin in striatum associated with enkephalin
14) Confidence 0.85 Published 1983 Journal J. Chromatogr. Section Title Doc Link 6841525 Disease Relevance 0 Pain Relevance 0.27
Furthermore, the prodrugs are shown to afford global stabilization of the Leu-enkephalin molecule towards the enzymes, aminopeptidase N and angiotensin converting enzyme, primarily responsible for degradation of Leu-enkephalin at the blood-brain barrier and in plasma.
Protein_catabolism (degradation) of Leu-enkephalin in plasma associated with enkephalin
15) Confidence 0.81 Published 1999 Journal Eur J Pharm Sci Section Abstract Doc Link 9971915 Disease Relevance 0 Pain Relevance 0.52
The purified placental aminopeptidase M actively degraded Met-enkephalin (Met-Enk) and Leu-enkephalin (Leu-Enk) completely into constituent 5 amino acids.
Protein_catabolism (degraded) of Leu-enkephalin associated with enkephalin
16) Confidence 0.79 Published 1988 Journal Exp. Clin. Endocrinol. Section Abstract Doc Link 2907492 Disease Relevance 0 Pain Relevance 0.41
The prodrug derivatives are shown to degrade stoichiometrically to Leu-enkephalin in phosphate buffer [t1/2 (0.05 M phosphate buffer without KCl): acetone prodrug (II) 930 min; cyclopentanone prodrug (III): 216 min; cyclohexanone prodrug (IV): 432 min; 4-methylcyclohexanone prodrug (V): 792 min].
Protein_catabolism (degrade) of Leu-enkephalin associated with enkephalin
17) Confidence 0.72 Published 1999 Journal Eur J Pharm Sci Section Abstract Doc Link 9971915 Disease Relevance 0 Pain Relevance 0.46
While leucine-enkephalin itself was rapidly degraded (t1/2 = 14.8 min), the glycated-derivative was slowly converted (t1/2 = 14 h) to the corresponding Amadori /compound of Tyr-Gly-Gly and Phe-Leu.
Protein_catabolism (degraded) of leucine-enkephalin associated with enkephalin
18) Confidence 0.69 Published 2004 Journal Bioorg. Chem. Section Abstract Doc Link 15530992 Disease Relevance 0.07 Pain Relevance 0.59
Age-induced increase of leucine enkephalin enzyme degradation in human plasma.
Protein_catabolism (degradation) of leucine enkephalin enzyme in plasma associated with enkephalin
19) Confidence 0.69 Published 1998 Journal Peptides Section Title Doc Link 9786164 Disease Relevance 0 Pain Relevance 0.29
[G-3H]Leu-enkephalin was prepared by the method of solid phase catalytic isotope exchange (120 Ci/mmol) and subjected to proteolysis by the treatment with blood plasma.
Protein_catabolism (proteolysis) of Leu-enkephalin in blood associated with enkephalin
20) Confidence 0.64 Published 2004 Journal Bioorg. Khim. Section Abstract Doc Link 15344652 Disease Relevance 0 Pain Relevance 0.56

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