INT96640

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 7.22
Pain Relevance 2.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr1) intracellular (Egr1) DNA binding (Egr1)
transcription factor binding (Egr1) cytoplasm (Egr1)
Anatomy Link Frequency
eyes 4
hippocampus 3
anatomic regions 2
cerebral cortex 1
Egr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 6 98.32 Very High Very High Very High
Dopamine 6 97.76 Very High Very High Very High
Inflammation 33 97.52 Very High Very High Very High
cerebral cortex 4 96.84 Very High Very High Very High
Hippocampus 3 96.04 Very High Very High Very High
cINOD 6 94.08 High High
Inflammatory mediators 6 93.84 High High
anesthesia 9 90.08 High High
substance P 2 89.20 High High
Enkephalin 4 87.92 High High
Disease Link Frequency Relevance Heat
Aids-related Complex 73 100.00 Very High Very High Very High
Cancer 21 100.00 Very High Very High Very High
Adenocarcinoma 1 99.48 Very High Very High Very High
INFLAMMATION 54 97.52 Very High Very High Very High
Hemorrhagic Shock 39 93.88 High High
Shock 10 91.52 High High
Stress 19 89.44 High High
Sprains And Strains 58 86.88 High High
Myopia 39 86.84 High High
Adhesions 9 85.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Egr-1 mRNA expression diminished after 4 h of resuscitation, whereas Egr-1 protein expression and DNA binding activity persisted through resuscitation.
Negative_regulation (persisted) of Gene_expression (expression) of Egr-1
1) Confidence 0.43 Published 2007 Journal Shock Section Abstract Doc Link 17224790 Disease Relevance 1.36 Pain Relevance 0.24
Northern blot analysis was performed to evaluate Egr-1 messenger RNA (mRNA) expression.
Negative_regulation (evaluate) of Gene_expression (expression) of Egr-1 messenger RNA
2) Confidence 0.43 Published 2007 Journal Shock Section Abstract Doc Link 17224790 Disease Relevance 1.50 Pain Relevance 0.21
The Egr-1 mRNA expression diminished after 4 h of resuscitation, whereas Egr-1 protein expression and DNA binding activity persisted through resuscitation.
Negative_regulation (diminished) of Gene_expression (expression) of Egr-1
3) Confidence 0.43 Published 2007 Journal Shock Section Abstract Doc Link 17224790 Disease Relevance 1.34 Pain Relevance 0.24
In all groups, Egr-1 mRNA expression was reduced in diffuser-treated eyes.
Negative_regulation (reduced) of Gene_expression (expression) of Egr-1 mRNA in eyes
4) Confidence 0.42 Published 2007 Journal Molecular Vision Section Abstract Doc Link PMC2774458 Disease Relevance 0 Pain Relevance 0
The influence of form deprivation on Egr-1 mRNA expression [21] could be confirmed and strengthened in the present study, since Egr-1 expression was decreased in the diffuser-treated eyes at all time points even though the intensity of the retinal images was matched in both eyes.
Negative_regulation (decreased) of Gene_expression (expression) of Egr-1 in eyes
5) Confidence 0.42 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.17 Pain Relevance 0
Expression of Egr-1 and cFos mRNA as a function of time
Negative_regulation (function) of Gene_expression (Expression) of Egr-1
6) Confidence 0.42 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.07 Pain Relevance 0
Moreover, there was no consistent overlap of anatomic regions affected by decreased GR and egr-1 protein expression.
Negative_regulation (decreased) of Gene_expression (expression) of egr-1 in anatomic regions
7) Confidence 0.41 Published 2010 Journal Dev. Neurosci. Section Abstract Doc Link 20453467 Disease Relevance 0.98 Pain Relevance 0.19
Overexpression of Egr-1 reduced cellular invasion in the Matrigel system, whereas suppression of Egr-1 by small interference RNA (siRNA) attenuated the inhibition of Matrigel invasion by these compounds, indicating that Egr-1 is responsible for the decrease in invasion reported following treatment with NSAIDs.
Negative_regulation (reduced) of Gene_expression (Overexpression) of Egr-1 associated with cinod
8) Confidence 0.41 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 16227405 Disease Relevance 0.52 Pain Relevance 0.28
At 16 weeks, the expression of the reported tumor suppressor gene EGR1, remained decreased as was found at 4 weeks post-exposure.
Negative_regulation (decreased) of Gene_expression (expression) of EGR1 associated with cancer
9) Confidence 0.41 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 0.81 Pain Relevance 0.08
Inhibition of Egr-1 expression reduced substantially LPS-mediated induction of COX-2 and mPGES-1 expression, resulting in a decrease in PGE(2) production.
Negative_regulation (Inhibition) of Gene_expression (expression) of Egr-1
10) Confidence 0.39 Published 2010 Journal Cell. Signal. Section Abstract Doc Link 20546888 Disease Relevance 0.13 Pain Relevance 0.07
Basal zif268 and arc mRNAs expression was reduced in mutant mice by 60-80%, not only in the striatum but also widespread in the cerebral cortex and hippocampus.
Negative_regulation (reduced) of Gene_expression (expression) of zif268 in hippocampus associated with aids-related complex, hippocampus and cerebral cortex
11) Confidence 0.36 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11432985 Disease Relevance 0.10 Pain Relevance 0.55
Inhibition of Egr-1 expression reduced substantially LPS-mediated induction of COX-2 and mPGES-1 expression, resulting in a decrease in PGE(2) production.
Negative_regulation (reduced) of Gene_expression (expression) of Egr-1
12) Confidence 0.28 Published 2010 Journal Cell. Signal. Section Abstract Doc Link 20546888 Disease Relevance 0.13 Pain Relevance 0.07
Basal zif268 and arc mRNAs expression was reduced in mutant mice by 60-80%, not only in the striatum but also widespread in the cerebral cortex and hippocampus.
Negative_regulation (reduced) of in cerebral cortex Gene_expression (expression) of zif268 in hippocampus associated with aids-related complex, hippocampus and cerebral cortex
13) Confidence 0.12 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11432985 Disease Relevance 0.10 Pain Relevance 0.55

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