INT96643

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.15
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Gad2) Golgi apparatus (Gad2) plasma membrane (Gad2)
cytoplasm (Gad2)
Anatomy Link Frequency
pyramidal cells 2
brain 2
Gad2 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 14 100.00 Very High Very High Very High
Pyramidal cell 4 98.80 Very High Very High Very High
Enkephalin 3 98.66 Very High Very High Very High
substance P 1 98.36 Very High Very High Very High
GABAergic 40 97.60 Very High Very High Very High
Hippocampus 6 95.28 Very High Very High Very High
cerebral cortex 5 94.64 High High
Dopamine 4 90.96 High High
Glutamate 3 87.48 High High
dopamine receptor 1 79.12 Quite High
Disease Link Frequency Relevance Heat
Aids-related Complex 1 89.72 High High
Cognitive Disorder 5 58.64 Quite High
Syndrome 16 5.00 Very Low Very Low Very Low
Intellectual Impairment 16 5.00 Very Low Very Low Very Low
Epilepsy 14 5.00 Very Low Very Low Very Low
Lissencephaly 10 5.00 Very Low Very Low Very Low
Targeted Disruption 10 5.00 Very Low Very Low Very Low
Congenital Anomalies 9 5.00 Very Low Very Low Very Low
Convulsion 8 5.00 Very Low Very Low Very Low
Infantile Spasms 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Striatal expression of substance P and enkephalin mRNAs was reduced by about 50% and 30%, respectively, whereas the expression of GAD67 and GAD65 mRNAs was slightly increased and unaltered, respectively.
Positive_regulation (increased) of Gene_expression (expression) of GAD65 associated with enkephalin and substance p
1) Confidence 0.49 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11432985 Disease Relevance 0.09 Pain Relevance 0.66
In these mice BDNF expression in the visual cortex is higher than in wt mice starting from very early postnatal ages and this correlates with a precocious development of IGI, as shown by the faster developmental increase in inhibitory postsynaptic currents and GABA biosynthetic enzyme GAD65 in the perisomatic region of pyramidal cells.
Positive_regulation (increase) of Gene_expression (biosynthetic) of GAD65 in pyramidal cells associated with gaba and pyramidal cell
2) Confidence 0.22 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2854574 Disease Relevance 0.06 Pain Relevance 0.16
In contrast, Dlx2 electroporation in Arx-deficient brain slices induces GAD65 expression, suggesting that Arx is necessary to promote Dlx-dependent GABAergic cell migration, but is dispensable for Dlx ability to induce GABAergic cell fate commitment (Colasante et al., 2008).
Positive_regulation (induces) of Gene_expression (expression) of GAD65 in brain associated with gabaergic
3) Confidence 0.21 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2841486 Disease Relevance 0 Pain Relevance 0.37

General Comments

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