INT96649

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Context Info
Confidence 0.65
First Reported 2001
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.82
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (ARSA) plasma membrane (ARSA) lysosome (ARSA)
Anatomy Link Frequency
plasma 1
respiratory 1
ARSA (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 204 100.00 Very High Very High Very High
cytokine 8 92.12 High High
addiction 2 82.68 Quite High
Inflammatory mediators 2 64.08 Quite High
cerebral cortex 1 56.72 Quite High
Inflammation 8 54.96 Quite High
cINOD 4 50.00 Quite Low
Thoracotomy 4 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 24 99.68 Very High Very High Very High
Stomach Cancer 9 95.00 High High
Microcephaly 8 91.08 High High
Congenital Anomalies 22 90.32 High High
Intrauterine Growth Retardation 1 86.76 High High
Myocardial Infarction 2 82.96 Quite High
Autism 3 76.56 Quite High
Birth Weight 3 72.20 Quite High
Cancer 82 72.04 Quite High
Necrosis 2 71.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Seven genes reside in the duplicated area, which contains SHANK3, ACR, RABL2B, MAPK8IP2 (mitogen-activated protein kinase 8 interacting) and ARSA (arylsulfatase A, isoform b).
Gene_expression (contains) of ARSA
1) Confidence 0.65 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2892449 Disease Relevance 0.85 Pain Relevance 0.03
In contrast, NO-ASA failed to affect healing of gastric ulcers and failed to produce the rise in the plasma IL-1b levels and the increase of lipid peroxidation as compared to those recorded in ASA-treated animals.
Neg (failed) Gene_expression (produce) of NO-ASA in plasma
2) Confidence 0.62 Published 2001 Journal Med. Sci. Monit. Section Body Doc Link 11433182 Disease Relevance 0.06 Pain Relevance 0
Due to prevalence of respiratory and cardiovascular co-morbidity in elderly they are often placed at higher ASA classes.
Gene_expression (classes) of ASA in respiratory
3) Confidence 0.21 Published 2005 Journal World J Surg Oncol Section Body Doc Link PMC1079964 Disease Relevance 1.03 Pain Relevance 0
ASA (2 mM) was equally unable to increase TGF-?
Neg (unable) Gene_expression (unable) of ASA associated with aspirin
4) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842433 Disease Relevance 0.32 Pain Relevance 0.49
In conclusion, in the present study we show that at in vitro antiinflammatory concentrations ASA exerts a TGF-?
Gene_expression (exerts) of ASA associated with aspirin and inflammation
5) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842433 Disease Relevance 0.56 Pain Relevance 0.27

General Comments

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