INT96651

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Context Info
Confidence 0.37
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.26
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (F2rl1) signal transducer activity (F2rl1)
Anatomy Link Frequency
spinal cord 1
gut 1
F2rl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hyperalgesia 5 99.14 Very High Very High Very High
Inflammation 47 99.04 Very High Very High Very High
Spinal cord 16 96.40 Very High Very High Very High
antagonist 3 95.20 Very High Very High Very High
agonist 7 92.88 High High
qutenza 3 77.12 Quite High
Pain 7 75.00 Quite High
Visceral pain 1 73.72 Quite High
nMDA receptor 16 66.32 Quite High
nociceptor 4 55.12 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 5 99.14 Very High Very High Very High
INFLAMMATION 48 99.04 Very High Very High Very High
Hypersensitivity 13 94.44 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

29 93.60 High High
Nociception 14 89.16 High High
Diarrhoea 1 82.16 Quite High
Pain 8 75.00 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

1 73.72 Quite High
Dyspepsia 41 46.64 Quite Low
Ganglion Cysts 32 36.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The PAR-2-mediated secretion of pancreatic amylase was abolished by pretreatment with N(G)-nitro-L-arginine methyl ester (L-NAME), an NO synthase inhibitor.
Negative_regulation (abolished) of PAR-2-mediated
1) Confidence 0.37 Published 2002 Journal Life Sci. Section Abstract Doc Link 12231404 Disease Relevance 0 Pain Relevance 0.17
We therefore used RT-PCR to detect PAR2 receptor mRNA, and found that the PAR2 receptor is not down-regulated following TNBS induced inflammation (Fig 6c, d).
Negative_regulation (regulated) of PAR2 associated with inflammation
2) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2758842 Disease Relevance 0.67 Pain Relevance 0.43
This hyperalgesia was markedly diminished or absent in mice lacking the NK-1 receptor, preprotachykinin-A or PAR2 genes, or in rats treated with a centrally acting cyclooxygenase inhibitor or treated by spinal cord injection of NK-1 antagonists.
Negative_regulation (lacking) of PAR2 in spinal cord associated with hyperalgesia, antagonist and spinal cord
3) Confidence 0.34 Published 2001 Journal Nat. Med. Section Abstract Doc Link 11433347 Disease Relevance 0.70 Pain Relevance 0.69
Consequently, blockade of PAR-2 receptors at the periphery and/or inhibition of colonic luminal protease activity may be new interesting targets for the treatment of gut hypersensitivity and IBS.
Negative_regulation (blockade) of PAR-2 in gut associated with hypersensitivity
4) Confidence 0.27 Published 2008 Journal Eur Rev Med Pharmacol Sci Section Abstract Doc Link 18924448 Disease Relevance 0.35 Pain Relevance 0.11

General Comments

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