INT96652

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Context Info
Confidence 0.47
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 2.62
Pain Relevance 2.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (F2rl1, Tac1) extracellular space (Tac1) extracellular region (Tac1)
signal transducer activity (F2rl1)
Anatomy Link Frequency
afferent neurons 4
F2rl1 (Rattus norvegicus)
Tac1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hyperalgesia 16 100.00 Very High Very High Very High
Inflammation 8 90.88 High High
agonist 4 88.72 High High
Pain 12 75.00 Quite High
Spinal cord 4 62.40 Quite High
antagonist 4 60.00 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 16 100.00 Very High Very High Very High
Nociception 8 98.20 Very High Very High Very High
INFLAMMATION 4 90.88 High High
Pain 8 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using a combined pharmacological and gene-deletion approach, we have delineated a novel mechanism of neurokinin-1 (NK-1) receptor-dependent hyperalgesia induced by proteinase-activated receptor-2 (PAR2), a G-protein-coupled receptor expressed on nociceptive primary afferent neurons.
proteinase-activated receptor-2 Positive_regulation (induced) of neurokinin-1 in afferent neurons associated with nociception and hyperalgesia
1) Confidence 0.47 Published 2001 Journal Nat. Med. Section Abstract Doc Link 11433347 Disease Relevance 0.65 Pain Relevance 0.56
Using a combined pharmacological and gene-deletion approach, we have delineated a novel mechanism of neurokinin-1 (NK-1) receptor-dependent hyperalgesia induced by proteinase-activated receptor-2 (PAR2), a G-protein-coupled receptor expressed on nociceptive primary afferent neurons.
PAR2 Positive_regulation (induced) of neurokinin-1 in afferent neurons associated with nociception and hyperalgesia
2) Confidence 0.47 Published 2001 Journal Nat. Med. Section Abstract Doc Link 11433347 Disease Relevance 0.66 Pain Relevance 0.56
Using a combined pharmacological and gene-deletion approach, we have delineated a novel mechanism of neurokinin-1 (NK-1) receptor-dependent hyperalgesia induced by proteinase-activated receptor-2 (PAR2), a G-protein-coupled receptor expressed on nociceptive primary afferent neurons.
proteinase-activated receptor-2 Positive_regulation (induced) of NK-1 in afferent neurons associated with nociception and hyperalgesia
3) Confidence 0.31 Published 2001 Journal Nat. Med. Section Abstract Doc Link 11433347 Disease Relevance 0.65 Pain Relevance 0.56
Using a combined pharmacological and gene-deletion approach, we have delineated a novel mechanism of neurokinin-1 (NK-1) receptor-dependent hyperalgesia induced by proteinase-activated receptor-2 (PAR2), a G-protein-coupled receptor expressed on nociceptive primary afferent neurons.
PAR2 Positive_regulation (induced) of NK-1 in afferent neurons associated with nociception and hyperalgesia
4) Confidence 0.31 Published 2001 Journal Nat. Med. Section Abstract Doc Link 11433347 Disease Relevance 0.66 Pain Relevance 0.56

General Comments

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