INT96678

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Context Info
Confidence 0.47
First Reported 2001
Last Reported 2006
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 10
Disease Relevance 6.75
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TAT) mitochondrion (TAT) small molecule metabolic process (TAT)
biosynthetic process (TAT) cellular nitrogen compound metabolic process (TAT) cellular_component (TAT)
Anatomy Link Frequency
platelet 1
stem 1
T cells 1
TAT (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 4 87.28 High High
Freund adjuvant 32 85.84 High High
antagonist 1 80.72 Quite High
Pain 8 75.12 Quite High
MU agonist 1 75.00 Quite High
Enkephalin 1 74.92 Quite High
Opioid 1 65.00 Quite High
Analgesic 1 63.64 Quite High
analgesia 1 45.92 Quite Low
ketamine 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunization 104 100.00 Very High Very High Very High
Drug Induced Neurotoxicity 1 99.98 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 378 99.16 Very High Very High Very High
Sprains And Strains 40 96.80 Very High Very High Very High
Shock 16 94.64 High High
Apoptosis 8 94.36 High High
Viremia 152 93.60 High High
Stress 6 92.56 High High
Infection 112 91.76 High High
Sickle Cell Anemia 4 91.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Peroxynitrite radicals are involved in neurotoxicity associated with TAT.
TAT Binding (associated) of associated with drug induced neurotoxicity
1) Confidence 0.47 Published 2006 Journal Neurotoxicology Section Abstract Doc Link 16168488 Disease Relevance 0.66 Pain Relevance 0.46
Immunization with Tat Oyi raises antibodies in rabbits that are able to recognize different Tat variants even with mutations of up to 38 %, which is not possible with other Tat variants [22].
Tat Binding (recognize) of associated with immunization
2) Confidence 0.47 Published 2006 Journal Retrovirology Section Body Doc Link PMC1434768 Disease Relevance 0.69 Pain Relevance 0
Tat variability follows this geographical diversity with mutations of up to 38 % observed among Tat variants from A, B, C, D and E HIV-1 subtypes that do not alter Tat functions but do not allow cross recognition with Tat antibodies [22].
Tat Neg (not) Binding (recognition) of associated with acquired immune deficiency syndrome or hiv infection
3) Confidence 0.47 Published 2006 Journal Retrovirology Section Body Doc Link PMC1434768 Disease Relevance 0.60 Pain Relevance 0
Compared to 10 asymptomatic African-American controls, sickle cell subjects demonstrated significantly increased pretreatment: 1) flow cytometric expression of platelet membrane P-selectin (CD62p; p <0.01) and annexin V binding sites (p = 0.02); 2) plasma levels of platelet-specific secretory proteins platelet factor 4 (PF4) and beta-thromboglobulin (betaTG) (p <0.01 in both cases); 3) plasma products of thrombin generation, prothrombin fragment 1.2 (F1.2) and thrombin:antithrombin (TAT) complex (p <0.01 in both cases); and 4) plasma levels of thrombolytic products, D-dimer and plasmin:antiplasmin (PAP) complex (p <0.01 in both cases).
TAT Binding (complex) of in platelet associated with sickle cell anemia
4) Confidence 0.36 Published 2001 Journal Thromb. Haemost. Section Abstract Doc Link 11434703 Disease Relevance 0.52 Pain Relevance 0.34
Immunization with Tat Oyi raises antibodies in rabbits that are able to recognize different Tat variants even with mutations of up to 38 %, which is not possible with other Tat variants [22].
Tat Binding (Immunization) of associated with immunization
5) Confidence 0.36 Published 2006 Journal Retrovirology Section Body Doc Link PMC1434768 Disease Relevance 0.71 Pain Relevance 0
We compared, using rabbits, different adjuvants authorized for human use to test on ELISA the recognition of Tat variants from the five main HIV-1 subtypes.
Tat Binding (recognition) of associated with acquired immune deficiency syndrome or hiv infection
6) Confidence 0.35 Published 2006 Journal Retrovirology Section Abstract Doc Link PMC1434768 Disease Relevance 0.67 Pain Relevance 0
Extra-cellular Tat inhibits macrophage responses by binding to the Fas ligand membrane receptor [6] and inhibits cytotoxic T cell (CTL) responses due to its ability to cross cell membranes and induce apoptosis of uninfected T cells [7,8] via interaction with tubulin [8-10].
Tat Binding (binding) of in T cells associated with apoptosis
7) Confidence 0.35 Published 2006 Journal Retrovirology Section Body Doc Link PMC1434768 Disease Relevance 1.07 Pain Relevance 0
These studies outline how mutations can affect Tat cross recognition as shown in former studies [22,27].


Tat Binding (recognition) of
8) Confidence 0.35 Published 2006 Journal Retrovirology Section Body Doc Link PMC1434768 Disease Relevance 0.43 Pain Relevance 0.04
It is a trans-activating regulatory protein that stimulates efficient transcription of the viral genome, which requires structural changes of Tat to bind to a RNA stem-loop structure called TAR [3,4].
Tat Binding (bind) of in stem
9) Confidence 0.35 Published 2006 Journal Retrovirology Section Body Doc Link PMC1434768 Disease Relevance 0.73 Pain Relevance 0
Tat Oyi with Montanide or Calcium Phosphate gave rabbit sera able to recognize all Tat variants.
Tat Binding (recognize) of
10) Confidence 0.35 Published 2006 Journal Retrovirology Section Abstract Doc Link PMC1434768 Disease Relevance 0.68 Pain Relevance 0

General Comments

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